The Use of Infusional 5-Fluorouracil, Mitomycin C, and Radiation as the Primary Management of Esophageal Cancer

  • Lawrence R. Coia
  • Patrick Stafford
  • Paul F. Engstrom
  • Anthony R. Paul
  • Gerald E. Hanks
Part of the Medical Radiology book series (MEDRAD)

Abstract

The results of surgery or radiation therapy as primary management of esophageal cancer have been dismal, with median survivals generally less than 1 year and 5-year survivals under 10% (Earlan and Cunha-Melo 1980; Langer et al. 1986). There have been several reports which indicate that the use of concurrent chemotherapy and radiation therapy in the management of esophageal cancer may offer an alternative to the standard approaches (Coia et al. 1987; John et al. 1987; Keane et al. 1989). These studies demonstrate that excellent local control and palliation with a chance for long-term survival can be obtained.

Keywords

Toxicity Adenocarcinoma Oncol Thrombocytopenia Gastritis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Lawrence R. Coia
    • 1
  • Patrick Stafford
    • 1
  • Paul F. Engstrom
    • 2
  • Anthony R. Paul
    • 2
  • Gerald E. Hanks
    • 3
  1. 1.Fox Chase Cancer CenterUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of Medical OncologyFox Chase Cancer CenterPhiladelphiaUSA
  3. 3.School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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