Determining Factors of Tissue O2 Uptake

  • E. Vicaut
  • M. Duvelleroy
Conference paper
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 11)


The factors which affect O2 uptake by whole the body or by organs such as skeletal muscles have been extensively studied. Some of these studies have shown that O2 uptake (VO2) may be altered by changes in blood flow (Q) [1, 2], arterial oxygen tension (PaO2) [1,2], other blood gas parameters (O2 capacity [3], O2 hemoglobin affinity [4–7], or by saturation of the mitochondrial ATP-generating capacity [8]. However, in normal conditions, when O2 demand is low, it is generally admitted that O2 uptake is independent of these parameters [2]. More generally, O2 uptake is independent of O2 delivery until very low levels of O2 delivery are reached [9-11]. When O2 demand is high, tissue O2 uptake becomes O2 delivery-limited over a wider range. Recently, some experimental data in canine skeletal muscle have demonstrated that in situations of high O2 demand, O2 uptake can be limited not only by O2 delivery but also by O2 diffusion [12, 13]. In addition, certain pathological states such as adult respiratory distress syndrome and sepsis have been found to alter drastically the relationships between O2 delivery and O2 uptake [14–16].


Adult Respiratory Distress Syndrome Microvascular Network High Blood Flow Capillary Recruitment Terminal Arteriole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • E. Vicaut
  • M. Duvelleroy

There are no affiliations available

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