Abstract
There are several factors which may be important in the altered mental state observed in patients with sepsis. These include a direct central nervous system infection [1–3], endotoxin effects on the brain [4, 5], inadequate perfusion [6, 7], altered metabolism including disturbed plasma and brain amino acid levels [8–17], deranged amino acid transport across the blood brain barrier [15], abnormal levels of neurotransmitters in the brain [8, 16, 17], metabolic disturbances [6], liver insufficiency [8], multiple organ failure [14, 18] or complications of medical therapies.
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Part of this work was performed during Dr. Sprung’s tenure as a Lady Davis Visiting Professor at Hebrew University, Hadassah University Hospital, Department of Anesthesiology, Kiryat Hadassah, P.O. Box 12000, 91120 Jerusalem, Israel.
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Sprung, C.L. (1990). The Role of Amino Acid Changes in Septic Encephalopathy. In: Vincent, J.L. (eds) Update 1990. Update in Intensive Care and Emergency Medicine, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84125-5_6
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DOI: https://doi.org/10.1007/978-3-642-84125-5_6
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