Update 1990 pp 407-412 | Cite as

Reliability of Cardiac Output Measurements by the Thermodilution Method

  • J. R. C. Jansen
  • J. J. Schreuder
  • A. Versprille
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 10)


Since Fegler [1] introduced the thermodilution technique 35 years ago to measure mean cardiac output, many studies and as much discussions have been devoted to this topic. This chapter is an other extension of these discussions which serves the consideration of the reliability of the thermodilution method in patients during mechanical ventilation. In general, the method has been accepted as a clinical useful method, because it is simple, safe and swift. Commercial devices compute cardiac output instantaneously and present the value digitally together with an assessment of the quality of the thermodilution curve. By the commercial availability the thermodilution technique became extensively applied in cardiology, surgery and anesthesia. Moreover, it became an integral part of comprehensive monitoring of critically ill and severely traumatized patients.


Cardiac Output Cardiac Output Measurement Thermodilution Technique Thermodilution Method Thermodilution Cardiac Output 
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  1. 1.
    Fegler G (1954) Measurement of cardiac output in anaesthetised animals by a thermo-dilution method. Q J Exp Physiol 39:153–164Google Scholar
  2. 2.
    Ganz W, Swan HJC (1972) Measurement of bloodflow by thermodilution. Am J Cardiol 29:241–246PubMedCrossRefGoogle Scholar
  3. 3.
    Weisel RD, Berger RL, Hechtman HB (1975) Measurement of cardiac output by thermal dilution. N Engl J Med 292:67–72CrossRefGoogle Scholar
  4. 4.
    Levett JM, Replogle RL (1979) Thermodilution cardiac output: a critical analysis and review of literature. J Surg Res 27:392–404PubMedCrossRefGoogle Scholar
  5. 5.
    Runciman WB, Ilsley AH, Roberts JG (1981) An evaluation of thermodilution cardiac output measurement using the Swan-Ganz catheter. Anaesth Intens Care 9:208–220Google Scholar
  6. 6.
    Nelson LD, Houtchens BA (1982) Automatic vs. manual injections for thermodilution cardiac output determinations. Crit Care Med 10:190–192PubMedCrossRefGoogle Scholar
  7. 7.
    Wessel HU, Paul MH, James GW, Grahn AR (1971) Limitations of thermal dilution curves for cardiac output determinations. J Appl Physiol 30:643–652PubMedGoogle Scholar
  8. 8.
    Jansen JRC, Schreuder JJ, Bogaard JM, van Rooyen W, Versprille A (1981) The thermodilution technique for the measurement of cardiac output during artificial ventilation. J Appl Physiol 51:584–591PubMedGoogle Scholar
  9. 9.
    Jansen JRC, Versprille A (1986) Improvement of cardiac output estimation by the thermodilution method during mechanical ventilation. Intensive Care Med 12:71–79PubMedCrossRefGoogle Scholar
  10. 10.
    American Edwards Laboratories COM-2. Cardiac Output Computer Operations Manual 1989Google Scholar
  11. 11.
    Bassingthwaighte JB, Knopp TJ, Anderson DU (1970) Flow estimation by indicator dilution. (Bolus injection): Reduction of errors due to time-averaged sampling during unsteady flow. Circ Res 27:277–291PubMedGoogle Scholar
  12. 12.
    Hoffman JIE, Guz A, Charlier AA, Wilcken DEL (1965) Stroke volume in conscious dogs: effect of respiration, posture and vascular occlusion. J Appl Physiol 20:865–877PubMedGoogle Scholar
  13. 13.
    Morgan BC, Martin WE, Hornbein TF, Crawford EW, Fronek A (1966) Hemodynamic effects of intermittent positive pressure ventilation with and without an end-expiratory pause. Anesthesiology 27:584–590PubMedCrossRefGoogle Scholar
  14. 14.
    Vermeire P, Butler J (1968) Effect of respiration on pulmonary capillary blood flow in man. Circ Res 22:299PubMedGoogle Scholar
  15. 15.
    Versprille A (1987) Pulmonary blood flow and blood volume during positive pressure ventilation. In: Vincent JL (ed) Update in intensive care and emergency medicine. Springer, Berlin Heidelberg New York, Tokyo, pp 213–222Google Scholar
  16. 16.
    Armengol J, Man GCW, Balsys AJ (1981) Effects of the respiratory cycle on cardiac output measurements: Reproducibility of data enhanced by timing the thermodilution injections in dogs. Crit Care Med 9:852–854PubMedCrossRefGoogle Scholar
  17. 17.
    Snyder JV, Powner DJ (1982) Effects of mechanical ventilation on the measurement of cardiac output by thermodilution. Crit Care Med 10:677–682CrossRefGoogle Scholar
  18. 18.
    Okamoto K, Komatsu T, Kumar V, et al (1986) Effects of intermittent positive-pressure ventilation on cardiac output measurements by thermodilution. Crit Care Med 14:977–980PubMedCrossRefGoogle Scholar
  19. 19.
    Stevens JH, Raffin TA, Mihm FG, Rosenthal MH, Stetz CW (1985) Thermodilution cardiac output measurement. Effect of the respiratory cycle on its reproducibility. JAMA 253:2240–2242PubMedCrossRefGoogle Scholar
  20. 20.
    Scheuer-Leeser M, Morquet A, Reul H, Inrich W (1977) Some aspects to the pulsation error in blood-flow calculations by indicator dilution technique. Med Biol Eng Comput 15:118–123PubMedCrossRefGoogle Scholar
  21. 21.
    Von Reth EA, Aerts JC, van Steenhoven AA, Versprille A (1983) Model studies on the influence of nonstationary flow on the mean flow estimate with the indicator-dilution technique. J Biomech 16:625–633CrossRefGoogle Scholar
  22. 22.
    Versprille A, Jansen JRC (1985) Mean systemic filling pressure as a characteristic pressure for venous return. Pflügers Archiv 405:226–271PubMedCrossRefGoogle Scholar
  23. 23.
    Jansen JRC, Bogaard JM, Versprille A (1987) Extrapolation of thermodilution curves obtained during a pause in artificial ventilation. J Appl Physiol 63:1551–1557PubMedGoogle Scholar
  24. 24.
    Zierler KL (1962) Circulation times and the theory of indicator-dilution methods for determining blood flow and volume. In: Handbook of physiology. Circulation. Am Physiol Soc (sect. 1) vol 1, chap 18, pp 585–615Google Scholar

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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. R. C. Jansen
  • J. J. Schreuder
  • A. Versprille

There are no affiliations available

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