Abstract
Heart failure is commonly accompanied by a major defect in myocardial function. The complexity of the structure of the heart explains the many possibilities of abnormal function: anatomical defects, valvular abnormalities, defects in the contractile machinery and reduced O2 supply all may result in inability of the heart to pump blood to meet the demands of the body. The inability of the pump performance of the heart initially results in compensatory mechanisms such as elevation in filling pressures with pulmonary congestion, followed by decreased cardiac output with general circulatory insufficiency.
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References
Streeter DD Jr, Hanna WT (1973) Engineering mechanics for successive states in canine left ventricular myocardium. II. Fiber angle and sacomere length. Circ Res 23:656–664
Sabbah HN, Marzilli M, Stein PD (1981) The relative role of subendocardium and subepicardium in left ventricular mechanics. Am J Physiol 240:H920-H926
Gallagher KP, Osakada G, Matsuzaki M, Miller M, Kemper WS, Ross J Jr (1985) Nonuni-formity of inner and outer systolic wall thickening in conscious dogs. Am J Physiol 249:H241-H248
Feigl EO (1983) Coronary physiology. Physiol Rev 63:1–205
Buckberg GD, Fixier DE, Archie JP, Hoffman JIE (1972) Experimental subendocardial ischemia in dogs with normal coronary arteries. Circ Res 30:67–81
Canty JM Jr (1988) Coronary pressure-function and steady-state pressure-flow relation during autoregulation in the anesthetized dog. Circ Res 63:821–836
Hess DS, Bache RJ (1976) Transmural distribution of myocardial blood flow during systole in the awake dog. Circ Res 38:5–15
Hoffman JIE (1984) Maximal coronary flow and the concept of coronary vascular reserve. Circulation 70:153–159
Mosher P, Ross J Jr, McFate PA, Shaw RF (1964) Control of coronary blood flow by an autoregulation mechanism. Circ Res 14:250–259
Breisch EA, Houser SR, Carey RA, Spann JF, Bove AA (1980) Myocardial blood flow and capillary density in chronic pressure overload of the feline left ventricle. Cardiovasc Res 14:469–475
O’Keefe DO, Hoffman JIE, Cheitlin R, O’Neill MJ, Allard JR, Shapkin E (1978) Coronary blood flow in experimental canine left ventricular hypertrophy. Circ Res 43:43–51
Bache JR (1988) Effects of hypertrophy on the coronary circulation. Progr Cardiovasc Dis 30:403–440
Bache RJ, Vrobel TR, Arentzen CE, Ring WS (1981) Effect of maximal coronary vasodilation on trasmural myocardial perfusion during tachycardia in dogs with left ventricular hypertrophy. Circ Res 49:742–750
Rembert JC, Kleinman RH, Fedor JM, Wechsler AS, Greenfield JC Jr (1978) Myocardial blood flow distribution in concentric left ventricular hypertrophy. J Clin Invest 62:379–386
Hittinger L, Shannon RP, Bishop SP, Gelpi R, Vatner SF (1989) Subendomyocardial exhaustion of blood flow reserve and increased fibrosis in conscious dogs with heart failure. Circ Res 65:971–980
Fujii AM, Gelpi RJ, Mirsky I, Vatner SF (1988) Systolic and diastolic dysfunction during atrial pacing in conscious dogs with left ventricular hypertrophy. Circ Res 62:462–470
Hittinger L, Shannon RP, Kohin S, et al (1990) Isoproterenol induced alterations in myocardial blood flow, systolic and diastolic function in conscious dogs with heart failure. Circulation (in press)
Hittinger L, Shannon RP, Kohin S, Manders WT, Kelly P, Vatner SF (1990) Exercise induced subendocardial dysfunction in dogs with left ventricular hypertrophy. Circ Res 66 (in press)
Marcus ML, Doty DB, Hiratzka LF, Wright CB, Eastham CL (1982) Decreased coronary reserve. A mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries. N Engl J Med 307:1362–1367
Homans DC, Sublett E, Lindstrom P, Nesbitt T, Bache RJ (1988) Subendocardial and subepicardial wall thickening during ischemia in exercising dogs. Circulation 78:1267–1276
Paulus WJ, Grossman W, Serizawa T, Bourdillon PD, Pasipoularides A, Mirsky I (1985) Different effects of two types of ischemia on myocardial systolic and diastolic function. Am J Physiol 248:H719-H728
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© 1990 Springer-Verlag Berlin Heidelberg
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Heyndrickx, G. (1990). Role of Subendocardial Ischemia in the Pathogenesis of Heart Failure. In: Vincent, J.L. (eds) Update 1990. Update in Intensive Care and Emergency Medicine, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84125-5_35
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DOI: https://doi.org/10.1007/978-3-642-84125-5_35
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52269-0
Online ISBN: 978-3-642-84125-5
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