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Medicinal and Aromatic Plants III pp 398–418Cite as

Scutellaria baicalensis Georgi: In Vitro Culture and the Production of Flavonoids

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Part of the book series: Biotechnology in Agriculture and Forestry ((AGRICULTURE,volume 15))

Abstract

The genus Scutellaria belongs to the family Labiatae and subfam. Scutellarideae. Scutellaria is widely distributed all over the world except for South Africa, and there are about 300 species. The calyx of this genus is remarkably specialized to become two-lip-shaped, and characterized by the upper lip having a flat or dish-shaped upper surface on which a small swelling forms; the dish-shaped part peels off at fruit maturation to allow a seed to fall.

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References

  • Aonuma S, Miura T, Tarutani M (1957) Effects of Coptis, Scutellaria, Rhubarb and Bupleurum on the serum cholesterol and phospholipid. Yakugaku Zashii 77:1303–1306.

    CAS  Google Scholar 

  • Hahlbrock K, Ebel J, Ortamann R, Sutter A (1971) Regulation of enzyme activities related on the biosynthesis of flavone glycosides in cell suspension cultures of parsley (Petroselinum hortense). Biochim Biophys Acta 244:7–15.

    Article  PubMed  CAS  Google Scholar 

  • Hirai Y, Takase H, Kobayashi H, Yamamoto M, Fujioka N, Kohda H, Yamasaki K, Yasuhara T, Nakajima T (1983) Screening test for anti-inflammatory crude drugs bases on inhibition effect of histamin release from mast cell. Shoyakugaku Zasshi 37:347–380.

    Google Scholar 

  • Institute of Pharmacy, Chinese Ministry of Sciences (ed) (1979) Chinese pharmacopoeia I. Peoples Hygienic Publications, Beijing, pp 546–555.

    Google Scholar 

  • Izawa B (1966) Coloured illustrations of medicinal plant (materia medica) of Japan. 2. Seibundo-Shincosha, Tokyo, pp 125–127.

    Google Scholar 

  • Kimura Y, Kubo M, Tani T, Arichi S, Ohminami H, Okuda H (1981a) Studies on Scutellariae Radix III. Effect on lipid metabolism in serum, liver, fat cell of rat. Chem Pharm Bull 29:2308–2312.

    Article  PubMed  CAS  Google Scholar 

  • Kimura Y, Kubo M, Tani T, Arichi S, Okuda H (1981b) Studies on Scutellariae Radix IV. Effects on lipid peroxidation in rat liver. Chem Pharm Bull 29:2610–2617.

    Article  Google Scholar 

  • Kimura Y, Okuda H, Tani H, Arichi S (1982a) Studies on Scutellariae Radix V. Effects of flavone compounds on lipid peroxidation in rat liver. Chem Pharm Bull 30:1792–1795.

    Article  PubMed  CAS  Google Scholar 

  • Kimura Y, Kubo M, Kusaka K, Tani T, Higashino M, Arichi S, Okuda H (1982b) Studies on Scutellariae Radix VI. Effects on ethanol-induced hyperlipemia and lipolysis in isolated fat cell. Chem Pharm Bull 30:219–222.

    Article  PubMed  CAS  Google Scholar 

  • Kimura Y, Okuda H, Arichi S (1985) Studies on Scutellariae Radix. Effects of various flavonoids on arachidonate metabolism in leukucytes. Planta Med 47:132–136.

    Article  Google Scholar 

  • Kitamura S, Murata G, Hori M (1975) Coloured illustrations of herbaceous plants of Japan (Sympetalae), rev edn, Hoikusha, Tokyo, pp 186–187.

    Google Scholar 

  • Koda A (1973) Pharmacological action of Scutellariae radix, principally baicalin and baicalein. Metab Disease (J Wakanyaku) 10:268–277.

    Google Scholar 

  • Koda A (1987) The relationship between crude drugs and allergic reaction. In: 34 Annu Meet Jpn Soc Pharmacog, Osaka, October, pp 9-12.

    Google Scholar 

  • Koda A, Sakai K (1966) Pharmacological action of baicalin and baicalein. Folia Pharmacol Jpn 62:39–40.

    Google Scholar 

  • Koda A, Nagai H, Wada H (1970a) The pharmacological action of baicalin and baicalein(I). Effects of active anaphylactic reactions. Folia Pharmcol Jpn 66:194–213.

    Article  CAS  Google Scholar 

  • Koda A, Nagai H, Wada H (1970b) The pharmacological action of baicalin and baicalein(II). Effect upon dependent anaphylactic reaction. Folia Pharmacol Jpn 66:237–247.

    Article  CAS  Google Scholar 

  • Koda A, Nagai H, Yoshida Y, Ro Hon Cat (1970c) The pharmacological action of baicalin and baicalein(III). Effect upon experimental asthma. Folia Pharmacol Jpn 66:471–486.

    Article  CAS  Google Scholar 

  • Koda A, Katsuta E, Watanabe S, Mizuno M (1970d) Anti-allergic action of crude drugs. Folia Pharmacol Jpn 66:366–378.

    Article  CAS  Google Scholar 

  • Koda A, Nishi K, Nagai H, Matsuura N, Tsutiya H (1982) Anti-allergic actions of crude drugs and blended Chinese traditional medicines. Effectson Type I and Type IV. Folia Pharmacol Jpn 80:31–41.

    Article  CAS  Google Scholar 

  • Koso New Medical Institute (ed) (1978) Dictionary of Chinese medicines, vol A. Sci Tech Publ, Shanghai, pp 2017–2021.

    Google Scholar 

  • Krenzaler E, Hahlbrock K (1973) Flavonoid glycosides from illuminated cell suspension culture of Petroselium hortense. Phytochemistry 12:1149–1152.

    Article  Google Scholar 

  • Kubo M, Kimura Y, Odani T, Tani T, Namba T (1981) Studies on Scutellariae Radix. Planta Med 43:194–201.

    Article  PubMed  CAS  Google Scholar 

  • Kubo M, Matsuda H, Tanaka M, Kimura Y, Okuda H, Higashino M, Tani T, Namba K, Arichi S (1984) Studies on Scutellariae Radix VII. Anti-arthritic and anti-inflammatory action of methanolic extract and flavonoid components from Scutellariae Radix. Chem Pharm Bull 32:2724–2729.

    Article  PubMed  CAS  Google Scholar 

  • Kubo M, Matsuda H, Tani T, Arichi S, Kimura Y (1985) Studies on Scutellariae Radix XII. Anti-thrombic action various flavonoid from Scutellariae Radix. Chem Pharm Bull 33:2411–2415.

    Article  PubMed  CAS  Google Scholar 

  • Kumazaki H (1958) On the pharmacological action of the Scutellaria, a Chinese crude drug. Gifu Pharm Univ Bull 6:94–111; 153-163; 164-168; 352-359; 372-376.

    Google Scholar 

  • Linsmaier EM, Skoog F (1965) Organic growth factor requirements of tobacco tissue culture. Physiol Plant 18:100–127.

    Article  CAS  Google Scholar 

  • Liu Y-L, Li N-W, Sung W-C, Wu C (1980) Study on the flavonoid constituents in Scutallaria amoena Wright. Chung Tsáo Yao 11:337–340.

    CAS  Google Scholar 

  • Miyaichi Y, Imoto Y, Tomimori T, Chun-Ching Lin (1987) Studies on the constituents of Scutellaria species IX. On the flavonoid constituents of the root of Scutellaria indica L. Chem Pharm Bull 35:3720–3725.

    Article  CAS  Google Scholar 

  • Miyaichi Y, Imoto Y, Kizu H, Tomimori T (1988) Studies on the Nepalese crude drugs (X). On the flavonoid and stilbene constituents of the leaves of Scutellaria scandens Buch, Ham. ex D. Don. Shoyakugaku Zasshi 42:204–207.

    CAS  Google Scholar 

  • Nanking Pharmaceutical Institute (ed) (1959) Materials for medicine. Nanking Pharm Inst, Shoka, pp 637–640.

    Google Scholar 

  • Niphonkoteisho Kyokai (ed) (1986) Scutellaria root, Pharmacopoeia japonica editio Undecima, D. Hirokawa, Tokyo, pp 113–116.

    Google Scholar 

  • Nishiyori T, Koda A, Tani T, Arichi S (1982) Antiallergic action of crude drugs and blended Chinese traditional medicine. Proc Symp Wakan-Yaku 15:187–191.

    Google Scholar 

  • Satake Y, Ohwi J, Kitamura S, Watari S, Tominari T (1981) Wild flowers of Japan herbaceous plants. Heibonsha, Tokyo, pp 75–78.

    Google Scholar 

  • Shibata S, Hattori S (1931) Über die konstitution des baicalein und des wogonin. Yakugaku Zasshi 51:15–17.

    Google Scholar 

  • Takagi S, Yamaki M, Inoue K (1980) Studies on the water-soluble constituents of roots of Scutellaria baicalensis Georgi (Wogon). Yakugaku Zasshi 100:1220–1224.

    PubMed  CAS  Google Scholar 

  • Takagi S, Yamaki M, Inoue K (1981a) Flavone DI-C-glycoside from Scutellaria baicalensis. Phyto-chemistry 20:2443–2444.

    CAS  Google Scholar 

  • Takagi S, Yamaki M, Inoue K (1981b) On the minor constituents of the root of Scutellaria baicalensis Georgi (Wogon). Yakugaku Zasshi 101:899–903.

    PubMed  CAS  Google Scholar 

  • Takido M (1973) On the chemical constituents of the root of Scutellaria baicalensis (Wogon) and possibility of its clinical applications. Metab Disease (J Wakanyaku) 10:261–267.

    Google Scholar 

  • Takido M, Aimi M, Takahashi S, Yamanouchi S, Torii H, Doi S (1975) Studies on the constituents in the water extracts of crude drug I. On the roots of Scutellaria baicalensis Georgi (Wogon) (1). Yakugaku Zasshi 96:108–113.

    Google Scholar 

  • Takido M, Yasukawa K, Matsuura S, Iinuma M (1979) On the relative structure of skullcapflavone II, a flavone compound in the roots of Scutellaria baicalensis Georgi (Wogon). Yakugaku Zasshi 99:443–444.

    PubMed  CAS  Google Scholar 

  • Tomimori T, Miyaichi Y, Kizu H (1982) On the flavonoids constituents from the roots of Scutellaria baicalensis Georgi I. Yakugaku Zasshi 104:338–341.

    Google Scholar 

  • Tomimori T, Miyaichi Y, Imoto Y, Kizu H, Tanabe Y (1983) Studies on the constituents of Scutellaria species. II. On the flavonoid constituents of the root of Scutellaria baicalensis Georgi (2). Yakugaku Zasshi 103:607–611.

    CAS  Google Scholar 

  • Tomimori T, Miyaichi Y, Imoto Y, Kizu H, Tanabe Y (1984a) Studies on the constituents of Scutellaria species. III. On the flavonoid constituents of the root of Scutellaria baicalensis Georgi (3). Yakugaku Zasshi 104:524–528.

    PubMed  CAS  Google Scholar 

  • Tomimori T, Miyaichi Y, Imoto Y, Kizu H, Suzuki C (1984b) Studies on the constituents of Scutellaria species. IV. On the flavonoid constituents of the root of Scutellaria baicalensis Georgi (4). Yakugaku Zasshi 104:529–534.

    PubMed  CAS  Google Scholar 

  • Tomimori T, Miyaichi Y, Imoto Y, Kizu H (1984c) Studies on the constituents of Scutellaria species. V. On the flavonoid constituents of “Ban Zhi Lian”, the whole herb of Scutellaria rivularis Wall (1). Shoyakugaku Zasshi 38:249–252.

    CAS  Google Scholar 

  • Tomimori T, Jin H, Miyaichi Y, Toyofuku S, Namba T (1985) Studies on the constituents of Scutellaria species. VI. On the constituents of the root of Scutellaria baicalensis Georgi (5). Quantitative analysis of flavonoids in Scutellaria roots by high-performance liquid chromatography. Yakugaku Zasshi 105:148–155.

    PubMed  CAS  Google Scholar 

  • Tomimori T, Miyaichi Y, Imoto Y, Kizu H, Namba T (1986a) Studies on the Nepalese crude drugs. VI. On the flavonoid constituents of the root of Scutellaria discolor Colebr. (2) Chem Pharm Bull 34:406–408.

    Article  CAS  Google Scholar 

  • Tomimori T, Miyaichi Y, Jin H, Toyofuku S, Yamamoto M (1986b) Studies on the constituents of Scutellaria species. VII. Seasonal variations of growth and flavonoid content in the root of Scutellaria baicalensis Georgi. Shoyakugaku Zasshi 40:381–389.

    CAS  Google Scholar 

  • Tomimori T, Miyaichi Y, Imoto Y, Kizu H (1986c) Studies on the constituents of Scutellaria species (VIII). On the flavonoid constituents of “Ban Zhi Lian”, the whole herb of Scutellaria rivularis Wall (2). Shoyakugaku Zasshi 40:432–433.

    CAS  Google Scholar 

  • Trofimova NA (1982) Scutellaria baicalensis in isolated tissue culture (USSR). Rastit Resurs Yuzh Sib Ratsion Isp Okhrana, Tomsk, pp 80–82 (in Russian) [cf CA 99:155378z (1983)].

    Google Scholar 

  • Yamahara J, Yamada T, Nakanishi H, Sawada T, Fujimura H (1981) Inhibitory effect of crude drugs on the denaturation of human γ-globurin induced by heat and Cu2+. Shoyakugaku Zasshi 35:103–107.

    CAS  Google Scholar 

  • Yamamoto H, Chatani N, Kitayama Z, Tomimori T (1986a) Flavonoid production in Scutellaria baicalensis callus cultures. Plant Cell Tissue Org Cult 5:219–222.

    Article  CAS  Google Scholar 

  • Yamamoto H, Chatani N, Watanabe K, Tomimori T (1986b) Effect of carbon sources on the growth and flavonoid formation of Scutellaria baicalensis stem callus culture. Shoyakugaku Zasshi 40:19–25.

    CAS  Google Scholar 

  • Yamamoto H, Chatani N, Watanabe K, Tomimori T (1986c) Effect of culture period on the growth and flavonoid formation of Scutellaria baicalensis stem callus culture. Shoyakugaku Zasshi 40:26–32.

    CAS  Google Scholar 

  • Yamamoto H, Chatani N, Watanabe K, Tomimori T (1986d) Effects of 5% maltose and plant growth regulators on the callus growth and flavonoid formation of some Scutellaria baicalensis stem callus lines. Shoyakugaku Zasshi 40:33–39.

    CAS  Google Scholar 

  • Yamamoto H, Watanabe K, Tomimori T (1987) Effects of various growth inhibitors on the callus growth and flavonoid production of Scutellaria baicalensis callus cultures. Shoyakugaku Zasshi 41:97–101.

    Google Scholar 

  • Yamamoto H, Sano T, Tomimori T (1989a) Growth and flavonoid formation of Scutellaria baicalensis callus culture in liquid medium. Shoyakugaku Zasshi 43:87–92.

    CAS  Google Scholar 

  • Yamamoto H, Sano T, Takeuchi S, Tanaka M, Tomimori T (1989b) Flavonoid production by two-stage culture and differentiated roots of Scutellaria baicalensis callus in liquid medium. Shoyakugaku Zasshi 43:188–191.

    CAS  Google Scholar 

  • Yu L-R, Liu M-L, Wang X-T (1984) Studies on the flavonoids of Scutellaria viscidula Bunge. Acta Pharm Sin 19:397–398.

    CAS  Google Scholar 

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Authors and Affiliations

  1. School of Pharmacy, Hokuriku University, Kanagawa-Machi, Kanazawa 920-11, Japan

    H. Yamamoto

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  1. H. Yamamoto
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Editors and Affiliations

  1. A-137, New Friends Colony, New Delhi, 110065, India

    Y. P. S. Bajaj

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© 1991 Springer-Verlag Berlin Heidelberg

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Yamamoto, H. (1991). Scutellaria baicalensis Georgi: In Vitro Culture and the Production of Flavonoids. In: Bajaj, Y.P.S. (eds) Medicinal and Aromatic Plants III. Biotechnology in Agriculture and Forestry, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84071-5_24

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  • DOI: https://doi.org/10.1007/978-3-642-84071-5_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84073-9

  • Online ISBN: 978-3-642-84071-5

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