Intestinal Calcium Transport and Bone Mineralization in the Spontaneously Diabetic BB Rat
Diabetes mellitus is associated with a large number of abnormalities in calcium homeostasis: urinary calcium excretion in both human and experimental diabetes is increased; the duodenal calcium absorption is usually decreased in streptozotocin-induced diabetic rats and the duodenal calbindin concentration is similarly decreased (Table 1). The osteoblast function also seems to be impaired as suggested by decreased bone formation and possibly decreased bone mass in both experimental and human insulindependent diabetes mellitus (1). Moreover, the fetus or neonate of diabetic mothers have an increased risk for bone and calcium abnormalities, such as the caudal regression syndrome and neonatal hypocalcemia. The pathogenesis of these abnormalities is not well known. We, therefore, used the spontaneously diabetic BB rat, a model of human autoimmune diabetes, to study the effect of insulin deficiency on vitamin D and calcium homeostasis.
KeywordsDiabetic Animal Calcium Diet Urinary Calcium Excretion Total Body Calcium Increase Calcium Intake
Unable to display preview. Download preview PDF.
- 3.Charles MA, Tirunaguru P, Zolock DT, Morissey RL (1981) Duodenal calcium transport and calcium binding protein levels in experimental diabetes mellitus. Miner Electrolyte Metab 5: 15–22Google Scholar
- 4.Hough S, Avioli AV (1984) Alterations of bone and mineral metabolism in diabetes. In: Recent advances in diabetes, pp. 223–229. Nattrass M, Santiago JV (eds). Edinburgh: Churchill LivingstoneGoogle Scholar
- 5.Like AA (1985) Spontaneous diabetes in animals. In: Volk B, Arquilla ER. The diabetic pancreas. 2nd ed.: 385–413Google Scholar
- 7.Pansu D, Bellaton C, Roche C, Bronner F (1983) Duodenal and ileal calcium absorption in the rat and effects of vitamin D. Am J Physiol 244: G659 - G700Google Scholar
- 13.Verhaeghe J (1988) Calcium metabolism during reproduction in the diabetic BB rat. Thesis K.U. Leuven, pp. 1–154Google Scholar
- 14.Verhaeghe J, Thomasset M, Bréhier A, Van Assche FA, Bouillon R (1988) 1,25(OH)2D3 and Ca-binding protein in fetal rats: relationship to the ‘maternal vitamin D status. Am J Physiol 254: E505 - E512Google Scholar