Abstract
Calbindin belongs to the calmodulin family of intracellular calcium modulated proteins that reversibly bind calcium in the micromolar range (Van Eldik et al, 1982). Since the discovery of avian intestinal calbindin-D28k (Wasserman and Taylor, 1966) similar calcium binding proteins have been reported in other species and in many other tissues including kidney pancreas and brain (Christakos et al, 1989), suggesting multiple effects of the vitamin D endocrine system. This chapter will focus on the regulation of mammalian calbindin-D28k. The tissue specificity and regulation by 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) of calbindin will be addressed as well as receptor regulation as a possible mechanism for modulating calbindin’s response to hormone. In addition, the regulation of calbindin by factors other than 1,25(OH)2D3 will be considered.
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References
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© 1990 Springer-Verlag Berlin Heidelberg
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Christakos, S., Iacopino, A.M., Li, H., Lee, S., Gill, R. (1990). Regulation of Calbindin-D28K Gene Expression. In: Pansu, D., Bronner, F. (eds) Calcium Transport and Intracellular Calcium Homeostasis. NATO ASI Series, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83977-1_32
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DOI: https://doi.org/10.1007/978-3-642-83977-1_32
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