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Progressive Restrictions in Gap Junctional Communication during Development

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Parallels in Cell to Cell Junctions in Plants and Animals

Part of the book series: NATO ASI Series ((ASIH,volume 46))

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Abstract

One of the most fascinating challenges in developmental biology is to elucidate the mechanisms that control the organization of the body plan during embryonic development. In this regard intercellular transduction of signals is of particular importance for a coordinated pattern of cell differentiation. Because of their ability to allow the exchange of ions and small molecules up to a molecular weight of about 1200 D (Simpson et al., 1977), gap junctions have been proposed as a putative pathway for the intercellular transfer of developmentally important signals (Furshpan and Potter, 1968). In most of the embryos so far studied gap junctions appear in the early stages of development, when important developmental decisions take place (see Caveney, 1985; Guthrie, 1987 for reviews). More striking results have shown that differences in junctional communication may be found between embryonic tissues with different developmental programmes. The changes of functional gap junctional communication between cells with divergent developmental fates suggest an involvement of gap junctional-mediated signal transduction in the specialization and organization of the different domains of the embryo (Van den Biggelaar, 1988).

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References

  • Blennerhasset MG, Caveney S (1984) Developmental compartments are separated by a cell type with reduced junctional permeability. Nature 309: 361–364

    Article  Google Scholar 

  • Caveney S (1985) The role of gap junctions in development. Annu Rev Physiol 47: 319–335

    Article  PubMed  CAS  Google Scholar 

  • Dale B, De Santis A, Ortolani G, Rassotto M, Santella L (1982) Electrical coupling of blastomeres in early embryos of ascidians and sea urchins. Exptl Cell Res 140: 457–461

    Article  PubMed  CAS  Google Scholar 

  • De Laat SW, Tertoolen LGJ, Dorresteijn AWC, Van den Biggelaar JAM (1980) Intercellular communication patterns are involved in cell determination in early molluscan development. Nature 287: 546–548

    Article  PubMed  Google Scholar 

  • Dorresteijn AWC, Van den Biggelaar JAM, Bluemink JG, Hage WJ (1981) Electron microscopical investigations of the intercellular contacts during the early cleavage stages of Lymnaea stagnalis. Roux’s Arch Dev Biol 190: 215–220

    Article  Google Scholar 

  • Dorresteijn AWC, Bilinski SM, Van den Biggelaar JAM, Bluemink JG (1982) The presence of gap junctions during early Patella embryogenesis: An electron microscopical study. Dev Biol 91: 397–401

    Article  PubMed  CAS  Google Scholar 

  • Dorresteijn AWC, Wagemaker HA, De Laat SW, Van den Biggelaar JAM (1983) Dye-coupling between blastomeres in early embryos of Patella vulgata (Mollusca, Gastropoda ): Its relevance for cell determination. Roux’s Arch Dev Biol 192: 262–269

    Google Scholar 

  • Finbow ME, Buultjens TEJ, Serras F, Kam E, John S, Meagher L (1988) Immunological and biochemical analysis of the low molecular weight gap junctional proteins. In: Hertzberg EL, Johnson RG (eds) Modem Cell Biology Vol 7, pp 53–67. Alan R Liss, Inc, New York

    Google Scholar 

  • Fraser SE, Green CR, Bode HR, Gilula NB (1987) Selective disruption of gap junctional communication interferes with a patterning process in hydra. Science 237: 49–55

    Article  PubMed  CAS  Google Scholar 

  • Fraser SE, Green CR, Bode HR, Bode PM, Gilula NB (1988) A perturbation analysis of the role of gap junctional communication in developmental patterning. In: Hertzberg EL, Johnson RG (eds) Modem Cell Biology Vol 7, pp 515–526. Alan R Liss, Inc, New York

    Google Scholar 

  • Furshpan EJ, Potter DD (1968) Low-resistance junctions between cells in embryos and tissue culture. In: Moscona AA, Monroy A (eds) Current topics in developmental biology, Vol 3 pp 95127 Academic Press New York

    Google Scholar 

  • Georges D (1979) Gap and tight junctions in tunicates. Study in conventional and freeze-fracture techniques. Tiss Cell 11: 781–792

    Article  CAS  Google Scholar 

  • Guthrie SC (1987) Intercellular communication in embryos. In: De Mello WC (ed) Cell to cell communication. pp 223–244 Plenum Press, New York

    Chapter  Google Scholar 

  • Harris AL, Spray DC, Bennett MVL (1983) Control of intercellular communication by voltage dependence of gap junctional conductance. J Neurosci 3: 79–100

    PubMed  CAS  Google Scholar 

  • Kalimi GH, Lo CW (1988) Communication compartments in the gastrulating mouse embryo. J Cell Biol 107: 241–255

    Article  PubMed  CAS  Google Scholar 

  • Kimmel CB, Spray DC, Bennett MVL (1984) Developmental uncoupling between blastoderm and yolk cell in the embryo of the teleost Fundulus. Dev Biol 102: 483–487

    Article  PubMed  CAS  Google Scholar 

  • Knier JA, Merritt MW, White RL, Bennett MVL (1986) Voltage dependence of junctional conductance in ascidian embryos. Biol Bull 171: 495

    Google Scholar 

  • Kuhtreiber WM, Van Dongen CAM (1989) Microinjection of lectines, hyaluronidase and hyaluronate fragments interferes with cleavage deley and mesoderm induction in embryos of Patella vulgata. Dcv Biol 132: 436–441

    Article  CAS  Google Scholar 

  • Lane N, Dallai R, Burighel P, Martinucci GB (1986) Tight and Gap junctions in the intestinal tract of tunicates (Urochordata): a freeze-fracture study. J Cell Sci 84: 1–17

    PubMed  CAS  Google Scholar 

  • Lo CW, Gilula NB (1979) Gap junctional communication in the post-implantation mouse embryo. Cell 18: 411–422

    Article  PubMed  CAS  Google Scholar 

  • Lo CW (1988) Communication compartments in insect and mammalian development. In: Hertzberg EL, Johnson RG (eds) Modem Cell Biology Vol 7, pp 505–514. Alan R Liss, Inc, New York

    Google Scholar 

  • Loewenstein WR (1981) Junctional intercellular communication: The cell to cell membrane channel. Phyciol Res 61 (4): 829–913

    CAS  Google Scholar 

  • Knier JA, Bennett MVL (1986) Communication compartments in ascidian embryos at the blastopore stage. Biol Bull 171: 474

    Google Scholar 

  • Michalke W (1977) A gradient of diffusible substances in a monolayer of cultured cells. J Memb Biol 33: 1–20

    Article  CAS  Google Scholar 

  • Miyazaki S, Takahashi K, Tsuda K, Yoshii M (1974) Analysis of non linearity observed in the current-voltage relation of the tunicate embryo. J Physiol 238: 55–77

    PubMed  CAS  Google Scholar 

  • Nishida H, Satoh N (1985) Cell lineage analysis in ascidian embryos by intracellular injection of a tracer enzyme.II. The 16- and 32-cell stages. Dev Biol 110: 440–454

    Article  PubMed  CAS  Google Scholar 

  • Pitts JD, Finbow ME (1986) The gap junction. J Cell Sci Supp14: 239–266

    Google Scholar 

  • Serras F, Van den Biggelaar JAM (1987) Is a mosaic embryo also a mosaic of communication compartments?. Dev Biol 120: 132–138

    Article  PubMed  CAS  Google Scholar 

  • Serras F, Kuhtreiber WM, Krul MRL, Van den Biggelaar JAM (1985) Cell communication compartments in molluscan embryos. Cell Biol Int Rep 9: 731–736

    Article  PubMed  CAS  Google Scholar 

  • Serras F, Buultjens TEJ, Finbow ME (1988a) Inhibition of dye-coupling in Patella (Mollusca) embryos by microinjection of antiserum against Nephrops ( Arthropoda) gap junctions. Exptl Cell Res 179: 282–288

    Article  PubMed  CAS  Google Scholar 

  • Serras F, Baud C, Moreau M, Guerrier P, Van den Biggelaar JAM (1988b) Intercellular communication in the early embryo of the ascidian Ciona intestinalis. Development 102: 55–63

    Google Scholar 

  • Serras F, Dictus WJAG, Van den Biggelaar JAM (1989a) Changes in junctional communication in relation with cell cycle arrest and differentiation of trochoblasts in embryos of Patella vulgata. Dev Biol (in press)

    Google Scholar 

  • Serras F, Damen P, Dictus WJAG, Notenboom RGE, Van den Biggelaar JAM (1989b) Communication compartments in the ectoderm of embryos of Patella vulgata. Roux’s Archiv Dev Biol (in press)

    Google Scholar 

  • Sheridan JD (1987) Cell Communication and growth. In: De Mello WC (ed) Cell to Cell communication, pp 187–222. Plenum Press, New York

    Chapter  Google Scholar 

  • Simpson I, Rose B, Loewenstein WR (1977) Size limit of molecules permeating the junctional membrane channel. Science 195: 294–296

    Article  PubMed  CAS  Google Scholar 

  • Takahashi K, Yoshii M (1981) Development of the sodium, calcium and potassium channels in the cleavage arrested embryo of an ascidian. J Phisiol 315: 515–529

    CAS  Google Scholar 

  • Van den Biggelaar JAM (1977) Development of dorsoventral polarity and mesentoblast determination in Patella vulgata. J Morphol 154: 157–186

    Article  PubMed  Google Scholar 

  • Van den Biggelaar JAM, Guerrier P (1979) Dorsovcntral polarity and mesentoblast determination as concomitant results of cellular interactions in the mollusk Patella vulgata. Dev Biol 68: 462–471

    Article  PubMed  Google Scholar 

  • Van den Biggelaar JAM (1988) Intercellular communication and development. In: Hertzberg EL, Johnson RG (eds) Modem Cell Biology Vol 7, pp 469–471. Alan R Liss, Inc, New York

    Google Scholar 

  • Van den Biggelaar JAM, Serras F (1988) Determinative decisions and dye-coupling changes in the molluscan embryo In: Hertzberg EL, Johnson RG (eds) Modem Cell Biology Vol 7 pp 483493. Alan R Liss, Inc, New York

    Google Scholar 

  • Verdonk NH, Cather JN (1983) Morphogenetic determination and differentiation. In: Verdonk NH, Van den Biggelaar JAM, Tompa AS (eds) The Mollusca Vol 3, pp 215–252 Academic Press, New York

    Google Scholar 

  • Verdonk NH, Van den Biggelaar JAM (1983) Early development and the formation of the germ layers. In: Verdonk NH, Van den Biggelaar JAM, Tompa AS (eds) The Mollusca Vol 3, pp 91–122 Academic Press, New York

    Google Scholar 

  • Warner AE, Lawrence PA (1982) Permeability of gap junctions at the segmental border in insect epidermis. Cell 23: 247–252

    Google Scholar 

  • Weir MP, Lo CW (1984) Gap-junctional communication compartments in the Drosophila wing imaginal disk. Dev Biol 102: 130–146

    Article  PubMed  CAS  Google Scholar 

  • Wolpert L (1978) Gap junctions: channels for communication in development. In: Feldman J, Gilula NB, Pitts JD (eds) Intercellular junctions and synapses. pp 81–96 Wiley, New York

    Google Scholar 

  • Yamasaki H (1988) Role of gap junctional communication in malignant cell transformation. In: Herzberg El, Johnson RG (eds) Modem Cell Biology Vol 7, pp 449–465. Alan R. Liss, Inc, New York

    Google Scholar 

  • Zalokar M, Sardet C (1984) Tracing of cell lineage in embryonic development of Phallusia mammillata ( Ascidia) by vital staining of mitochondria. Dev Biol 102: 195–205

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Experimental Zoology, University of Utrecht, 3584 CH, Utrecht, The Netherlands

    Florenci Serras & Jo A. M. van den Biggelaar

Authors
  1. Florenci Serras
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  2. Jo A. M. van den Biggelaar
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Editor information

Editors and Affiliations

  1. Institute for Applied Biology, The University of York, Y01 5DD, York, UK

    A. W. Robards

  2. Department of Botany, University of California, 95616, Davis, CA, USA

    W. J. Lucas

  3. Beatson Institute for Cancer Research, Wolfson Laboratory for Molecular Pathology, Garscube Estate, Switchback Road, G61 1BD, Bearsden, Glasgow, UK

    J. D. Pitts

  4. Department of Physiology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    H. J. Jongsma

  5. Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Ave, 10461, Bronx, NY, USA

    D. C. Spray

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© 1990 Springer-Verlag Berlin Heidelberg

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Serras, F., van den Biggelaar, J.A.M. (1990). Progressive Restrictions in Gap Junctional Communication during Development. In: Robards, A.W., Lucas, W.J., Pitts, J.D., Jongsma, H.J., Spray, D.C. (eds) Parallels in Cell to Cell Junctions in Plants and Animals. NATO ASI Series, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83971-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-83971-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83973-3

  • Online ISBN: 978-3-642-83971-9

  • eBook Packages: Springer Book Archive

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