Long-Term Tissue Cultures of Newborn Rat Optic Nerve Cells : Functional Differentiation of Glia and Appearance of Neuron-Like Cells

  • F. X. Omlin
Conference paper
Part of the NATO ASI Series book series (volume 43)


A large body of literature documents depelopmental, functional, pathological and experimental aspects of optic nerve glia and progenitor cells (Vaughn, 1969; Skoff et al., 1976; Tennekoon et al., 1977; Aguayo et al., 1978; Juurlink and Federoff, 1980; Privat et al., 1981; Raff et al., 1983).


Optic Nerve Glial Fibrillary Acidic Protein Horse Radish Peroxidase Optic Stalk Dimensional Organization 
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  1. Aguayo AJ, Dickson R, Trecarten J, Attiwell M, Bray GM, Richardson P (1978) Ensheathment and myelination of regenerating PNS fibres by transplanted optic nerve glia. Neurosci Lett 9: 97–104PubMedCrossRefGoogle Scholar
  2. Honegger P, Richelson E (1976) Biochemical differentiation of mechanically dissociated mammalian brain in aggregating cell culture. Brain Res 109: 335–354PubMedCrossRefGoogle Scholar
  3. Juurlink BHJ, Fedoroff S (1980) Differentiation capabilities of mouse optic stalk in isolation of its immediate in vivo environment. Dev Biol 78: 215–221PubMedCrossRefGoogle Scholar
  4. Kiraly M, Maillard M, Omlin FX (1989) Functional characterization of astrocytes in rat optic nerve minisegments. Experimentia 45: 19Google Scholar
  5. Omlin FX, Waldmeyer J (1986) Minisegments of newborn rat optic nerves in vitro: Gliogenesis and myelination. Exp Brain Res 85: 189–99Google Scholar
  6. Omlin FX, Waldmeyer J (1989) Differentiation of neuron-like cells in cultured rat optic nerves: a neuron or common neuron-glia progenitor? Dev Biol 133: 247–253PubMedCrossRefGoogle Scholar
  7. Privat A, Valat J, Fulcrand J (1981) Proliferation of neuro-glial cell lines in the degenerating optic nerve of young rats. J Neuropath Exp Neurol 40: 46–60PubMedGoogle Scholar
  8. Raff MC, Miller RH, Noble M (1983) A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium. Nature 303: 390–396PubMedCrossRefGoogle Scholar
  9. Skoff RP, Price DL, Stocks A (1976) Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. 1. Cell proliferation. J Comp Neurol 169: 291–312PubMedCrossRefGoogle Scholar
  10. Tennekoon GI, Cohen SR, Price DL, McKhann GM (1977) Myelinogenesis in optic nerve. A Morphological, autoradiographic and biochemical analysis. J Cell Biol 72: 604–616PubMedCrossRefGoogle Scholar
  11. Vaughn JE (1969) An electron microscopic analysis of gliogenesis in rat optic nerves. Z Zellforsch 94: 293–324PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • F. X. Omlin
    • 1
  1. 1.Institute of Histology and EmbryologyUniversity of LausanneLausanneSwitzerland

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