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Cellular and Molecular Elements of Mammalian Fertilization

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Mechanism of Fertilization: Plants to Humans

Part of the book series: NATO ASI Series ((ASIH,volume 45))

Abstract

The concept of receptor-mediated gamete adhesion is widely accepted today to account for species specificity observed during fertilization in animals. Although this concept dates back more than 70 years to F.R. Lillie (Farley, 1982), macromolecules involved in gamete adhesion have been identified only recently. Here, I review some aspects of research on the mouse egg receptor for sperm, a zona pellucida glycoprotein called ZP3, that has been studied extensively at both the cellular and molecular level. Such studies have revealed that ZP3 regulates early events of the fertilization pathway in mice, including gamete recognition and adhesion (binding), and sperm exocytosis (acrosome reaction).

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Authors and Affiliations

  1. Department of Cell and Developmental Biology Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey, 07110, USA

    Paul M. Wassarman

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  1. Paul M. Wassarman
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Editors and Affiliations

  1. Stazione Zoologica, Villa Comunale, 80121, Naples, Italy

    Brian Dale

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© 1990 Springer-Verlag Berlin Heidelberg

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Wassarman, P.M. (1990). Cellular and Molecular Elements of Mammalian Fertilization. In: Dale, B. (eds) Mechanism of Fertilization: Plants to Humans. NATO ASI Series, vol 45. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83965-8_22

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  • DOI: https://doi.org/10.1007/978-3-642-83965-8_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83967-2

  • Online ISBN: 978-3-642-83965-8

  • eBook Packages: Springer Book Archive

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