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Cell Specific Gene Expression in Mouse Testis

  • Conference paper
Mechanism of Fertilization: Plants to Humans

Part of the book series: NATO ASI Series ((ASIH,volume 45))

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Abstract

Spermatogenesis is a complex differentiative process, highly conserved in the course of evolution, represented by the ordered sequence of mitotic, meiotic and differentiative stages. The pioneering work of Oakberg (1956), Monesi (1965) and Clermont (1972) have clearly shown that these stages are characterized by a complex series of biosynthetic processes which make spermatogenesis an excellent model system for the study of molecular events related to cell differentiation. DNA, RNA and protein synthesis were initially studied by autoradiographic and histochemical techniques, and only later with biochemical analysis after the introduction of cell fractionation techniques (Lam et al., 1970; Meistrich, 1973) which made available germ cells at defined stage of differentiation. Further insight into the genetic events and the mechanisms which control germ cell differentiation seems now possible with the use of powerful tools like molecular biology and transgenic techniques.

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Author information

Authors and Affiliations

  1. Dept. Public Health and Cell Biology, II University of Rome “Torvergata”, Via O. Raimondo 8, 00173, Roma, Italy

    R. Geremia, V. Sorrentino, M. Giorgi, P. Grimaldi, I. Sammarco & P. Rossi

  2. European Molecular Biology Laboratory, Meyerhoffstrasse 1, 6900, Heidelberg, Germany

    V. Sorrentino

Authors
  1. R. Geremia
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  2. V. Sorrentino
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  3. M. Giorgi
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  4. P. Grimaldi
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  5. I. Sammarco
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  6. P. Rossi
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Editor information

Editors and Affiliations

  1. Stazione Zoologica, Villa Comunale, 80121, Naples, Italy

    Brian Dale

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© 1990 Springer-Verlag Berlin Heidelberg

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Geremia, R., Sorrentino, V., Giorgi, M., Grimaldi, P., Sammarco, I., Rossi, P. (1990). Cell Specific Gene Expression in Mouse Testis. In: Dale, B. (eds) Mechanism of Fertilization: Plants to Humans. NATO ASI Series, vol 45. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83965-8_10

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  • DOI: https://doi.org/10.1007/978-3-642-83965-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83967-2

  • Online ISBN: 978-3-642-83965-8

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