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The Concept of Idiotypic Network: Deficient or Premature?

  • Z. Grossman
Part of the Springer Series in Synergetics book series (SSSYN, volume 46)

Abstract

“A discovery is premature if its implications cannot be connected by a series of simple logical steps to canonical, or generally accepted, knowledge” (1). If this is true, then the discovery of the idiotype-anti-idiotype network of lymphocytes (2) must be considered premature, since to this date it has not been successfully integrated, logically, into the growing body of knowledge about the immune system. Alternatively, the network hypothesis itself or the “accepted knowledge”, or both, are deficient. I shall argue in favor of the second possibility. But first I shall briefly refer to the body of knowledge and discuss whether the analytical tools in the hands of theoretical immunologists are capable of integrating or reshaping it in any substantial way.

Keywords

Major Histocompatibility Complex Suppressor Cell Major Histocompatibility Complex Molecule Dynamic Selection Associative Recognition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    G.S. Stent: Sci. Am. 227, 84, (1972).PubMedCrossRefGoogle Scholar
  2. 2.
    N.K. Jerne: Ann. Immunol. (Paris) 125C, 373 (1974).Google Scholar
  3. 3.
    W.C. Wimsatt: In Topics of the Philosophy of Biology, ed. by M. Grene and E. Mendelsohn (Reidel Publ. Co., Dordrecht and Boston, 1976).Google Scholar
  4. 4.
    W.E. Paul: J. Immunol. 139, 1 (1987).PubMedGoogle Scholar
  5. 5.
    F.M. Burnet: The Clonal Selection Theory of Acquired Immunity. (Univ. Press, Cambridge, 1991.Google Scholar
  6. 6.
    P. Marrack, I. Kappler: Science 238, 1073 (1987).PubMedCrossRefGoogle Scholar
  7. 7.
    N.A. Mitchison: In Cold Spring Harbor Symp. Quant. Biol. 32, 431 (1967).Google Scholar
  8. 8.
    R.K. Gershon, K. Kondo: Immunol. 18, 723 (1970).Google Scholar
  9. 9.
    Z. Grossman: Eur. J. Immunol. 12, 747 (1982).PubMedCrossRefGoogle Scholar
  10. 10.
    Z. Grossman: Immunol. Rev. 79, 119 (1984).PubMedCrossRefGoogle Scholar
  11. 11.
    Z. Grossman, G. Berke: J. Theor. Biol. 83, 267 (1980).PubMedCrossRefGoogle Scholar
  12. 12.
    A.A. Freitas, B. Rocha, A.A. Coutinho: Immunol. Rev. 91, 5 (1986).PubMedCrossRefGoogle Scholar
  13. 13.
    M. Conn: Cell. Immunol. 61, 425 (1981).CrossRefGoogle Scholar
  14. 14.
    R. Levins: Am. Sci. 54, 421 (1966).Google Scholar
  15. 15.
    Z. Grossman: Lec. Notes Biomath. 57, 312 (1985).Google Scholar
  16. 16.
    J. H. Humphrey: Ann. Rev. Immunol. 2, 1 (1984).CrossRefGoogle Scholar
  17. 17.
    P.B. Medawar: Induction and Intuition in Scientific Thought (Methuen, London, 1969).Google Scholar
  18. 18.
    J. Eisenfeld: Ann. N.Y. Acad. Sci. 504, 132 (1987).PubMedCrossRefGoogle Scholar
  19. 19.
    J. Eisenfeld, C. DeLisi: In Mathematics and Computers in Biomedical Applications, ed. by J. Eisenfeld and C. De Lisi (Elsvier, New York, 1985) p. 39.Google Scholar
  20. 20.
    I.R. Cohen, H. Atlan: Network regulation of autoimmunity: an automaton model. Preprint.Google Scholar
  21. 21.
    I.G. Kevrekidis, A.P. Zecha, A.S. Perelson: In Theoretical Immunology, Part One, SFI Studies in the Sciences of Complexity, ed. by A.S. Perelson (Addison-Wesley, 1988) p. 167.Google Scholar
  22. 22.
    A.R. Peacocke: An Introduction to the Physical Chemistry of Biological Organization (Clarendon Press, Oxford, 1983) p. 13.Google Scholar
  23. 23.
    R.E. Langman, M. Cohn: Immunol. Today 7, 100 (1986).CrossRefGoogle Scholar
  24. 24.
    A.S. Perelson: In Theoretical Immunology, Part Two, SFI Studies in the Sciences of Complexity, ed. by A.S. Perelson (Addison-Wesley, 1988) p.Google Scholar
  25. 25.
    J.D. Farmer, S.A. Kaufman, N.H. Packard, A.S. Perelson: Ann. N.Y. Acad. Sci. 504, 118 (1987).PubMedCrossRefGoogle Scholar
  26. 26.
    W.M. Elsasser: Reflection on a Theory of Organisms (Orbis, Quebec, 1987).Google Scholar
  27. 27.
    Z. Grossman, I.R. Cohen: Eur. J. Immunol. 10, 633 (1980).PubMedCrossRefGoogle Scholar
  28. 28.
    Z. Grossman, R. Asofsky, C. DeLisi: J. Theor. Biol. 84, 49 (1980).PubMedCrossRefGoogle Scholar
  29. 29.
    Z. Grossman, R.B. Herberman: Immunol. Today 7, 128 (1986).CrossRefGoogle Scholar
  30. 30.
    R.J. De Boer, P. Hogeweg: IMA J. Math. Applied in Medicine and Biology 4, 1 (1987).CrossRefGoogle Scholar
  31. 31.
    R.J. De Boer, P. Hogeweg: J. Theor. Biol. 124, 343 (1987).PubMedCrossRefGoogle Scholar
  32. 32.
    R.J. De Boer, P. Hogeweg: J. Theor. Biol. 120, 331 (1986).PubMedCrossRefGoogle Scholar
  33. 33.
    Z. Grossman: In Math. Modeling in Science and Technology, ed. by A. Avula et al. (Pergamon Press, New York, 1984) p. 933.Google Scholar
  34. 34.
    C. Penit: J. Immunol. 137, 2115 (1986).PubMedGoogle Scholar
  35. 35.
    L.A. Segel, A.S. Perelson: In Theoretical Immunology, Part Two, SFI Studies in the Sciences of Complexity, ed. by A.S. Perelson (Addison-Wesley, 1988) p. 321.Google Scholar
  36. 36.
    R.J. De Boer, P. Hogeweg: Symmetric idiotypic networks. II. Stability and unresponsiveness in high-dimensional models. Preprint.Google Scholar
  37. 37.
    P.H. Sugarbaker, et al.: Cancer Bull. 39, 38 (1987).Google Scholar
  38. 38.
    J. Quintans, et al.: J. Immunol. 136, 1974 (1986).PubMedGoogle Scholar
  39. 39.
    H. Suzuki, et al.: J. Mol. Cell Immunol. 2, 331 (1986).PubMedGoogle Scholar
  40. 40.
    H. Suzuki, J. Quintans: J. Mol. Cell Immunol. 2, 345 (1986).PubMedGoogle Scholar
  41. 41.
    C. Clayberger, R.H. DeKruyff, H. Cantor: J. Immunol. 132, 2237 (1984).PubMedGoogle Scholar
  42. 42.
    D. Baltimore: In Leukemia: Recent Advances in Biology and Treatment (A.R. Liss, 1985) p. 251.Google Scholar
  43. 43.
    N.A. Mitchison: Suppression of the response to murine alloantigens: Four-cell-type clusters, function-flipping and idiosyncratic responses. Progress in Allergy, to appear.Google Scholar
  44. 44.
    Immunol. Rev. 95 (1987).Google Scholar
  45. 45.
    Immunol. Rev. 100 (1987).Google Scholar
  46. 46.
    M.A. Lappe: Nat. Cancer Inst. Monogr. 35, 49 (1972).PubMedGoogle Scholar
  47. 47.
    E.S. Golub: Cell 27, 417 (1981).PubMedCrossRefGoogle Scholar
  48. 48.
    Z. Grossman, R.B. Herberman, S. Livnat: Neural modulation of immunity: Conditioning phenomena and the adaptability of lymphoid cells. Submitted.Google Scholar
  49. 49.
    Z. Grossman, W.E. Paul: The significance of lymphokine promiscuity. In preparation.Google Scholar
  50. 50.
    N.K. Jerne: In: The Neurosciences: A Study Program, ed. by T. Melnechuk and F.O. Schmitt (Rockefeller Univ. Press, 1967) p. 200.Google Scholar
  51. 51.
    N.K. Jerne: Sci. Am. 229(1), 52 (1973).PubMedCrossRefGoogle Scholar
  52. 52.
    M. Cohn: In Nucleic Acids in Immunology, ed. by O.S. Plescia and W. Brown (Springer, New York, 1968) p. 671.Google Scholar
  53. 53.
    G.W. Hoffman et al.: Physica D (1987).Google Scholar
  54. 54.
    J.D. Farmer, N.H. Packard, A.S. Perelson: Physica D (1987).Google Scholar
  55. 55.
    G. Parisi: A simple model for the immune system, Proc. Nat. Acad. Sci. (USA). In press.Google Scholar
  56. 56.
    G.M. Edelman: In The Mindful Brain: Cortical Organization of the Group-Selective Theory of Higher Brain function, ed. by G.M. Edelman and V.B. Mountcastle (MIT Press, Cambridge Mass., 1978) p.51.Google Scholar
  57. 57.
    S. Grossberg: Proc. Natl. Acad. Sci (USA) 77, 2338 (1980).PubMedCrossRefGoogle Scholar
  58. 58.
    McClelland, Rumelhart and the PDP Group: Parallel Distributed Processing (MIT Press, Cambridge Mass., 1986).Google Scholar
  59. 59.
    G.M. Edelman: In Organization of the Cerebral Cortex, ed. by F.O. Shmitt et al. (MIT Press, Cambridge Mass., 1981) p. 535.Google Scholar
  60. 60.
    Z. Grossman: Leuk. Res. 10, 937 (1986).PubMedCrossRefGoogle Scholar
  61. 61.
    Z. Grossman, R.F. Levine: In Megakaryocyte Development and function, ed. by R.F. Levine et al. (A.R. Liss, 1986) p. 51.Google Scholar
  62. 62.
    Z. Grossman, R.B. Herberman: Cancer Res. 64, 2651 (1986).Google Scholar
  63. 63.
    D. Marr: Vision (Freeman, San Francisco, 1982).Google Scholar

Copyright information

© Springer-Verlag Berlin, Heidelberg 1989

Authors and Affiliations

  • Z. Grossman
    • 1
    • 2
  1. 1.Department of Physiology and Pharmacology, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  2. 2.Pittsburgh Cancer InstituteUSA

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