Optimizing the Immune Control of Parasitic Invasion

Conference paper
Part of the Springer Series in Synergetics book series (SSSYN, volume 46)


The aim of this work is to identify the crucial tasks of the immune system in controlling parasitic invasion and to examine plausible molecular mechanisms by which these tasks may be effectuated. To this end the Sleeping Sickness, and its causative agent Trypanosoma brucei are discussed in terms of a general optimization problem, thus illustrating the major difficulties in controlling this disease. Subsequently an automata model is presented, of B-cell population dynamics under the constraints of a trypanosome-like pathogen. The efficacy of different mechanisms for optimizing the immune response are tested.


Majority Rule Genomic Mutation Immune Control Parasitic Invasion Antibody Repertoire 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    I. Roitt: Essential Immunology, Blackwell Scientific Publications (1988).Google Scholar
  2. 2.
    D.G. Bounds: Nature 329, 215 (1987).CrossRefGoogle Scholar
  3. 3.
    K.J. Vickerman: Cell Sci. 5, 163 (1969).Google Scholar
  4. 4.
    K.J. Vickerman: Nature 273, 613 (1987).CrossRefGoogle Scholar
  5. 5.
    G.A.M. Cross: Parasitology 71, 393 (1975).PubMedCrossRefGoogle Scholar
  6. 6.
    P. Borst: Ann. Rev. Biochem. 55, 701 (1986).PubMedCrossRefGoogle Scholar
  7. 7.
    Capbern: et al. Parasitol. 42, 6 (1982).Google Scholar
  8. 8.
    L.H.T. Van der Ploeg, D. Valerio, T. De Lange, A. Bernards, P. Borst, F.G. Grosveld: Nucl. Acids Res. 10, 5905 (1982).PubMedCrossRefGoogle Scholar
  9. 9.
    K. Vickerman & J.D. Barry: In The Immunology of Parasite Infection ed. by S. Cohen & K.S. Warren, Blackwell Scientific Publications, Oxford (1982).Google Scholar
  10. 10.
    R. Ross & D. Thomson: Proc. R. Soc. Lond. Biol. 82, 411 (1910).CrossRefGoogle Scholar
  11. 11.
    K.J. Vickerman: In Parasites in the Immunized Host: Mechanisms of Survival, Ciba Foundations Symposium (Elsevier), pp. 53-80 (1974).Google Scholar
  12. 12.
    J.E. Donelson, M.J. Turner: Sci Amer. 252, 32 (1985).CrossRefGoogle Scholar
  13. 13.
    T. Baltz, C. Giroud, D. Baltz, C. Roth, A. Raibaud, & H. Eisen: Nature 319, 602 (1986).PubMedCrossRefGoogle Scholar
  14. 14.
    A.W.C.A. Cornelissen, P. Johnson, J.M. Kooter, L.H.T. Van der Ploeg & P. Borst: Cell 41, 825 (1985).PubMedCrossRefGoogle Scholar
  15. 15.
    E.N. Miller & M.J. Turner: Parasitology 82, 63 (1981).PubMedCrossRefGoogle Scholar
  16. 16.
    D. Abiri, L.H.T. Van der Ploeg & Z. Agur: (to appear).Google Scholar
  17. 17.
    Z. Agur: IMA Jour. Math. App. Med. Biol. 4, 295 (1987).CrossRefGoogle Scholar
  18. 18.
    K. Rajewski, I. Förster, A. Cumano: Science 238, 1088 (1987).CrossRefGoogle Scholar
  19. 19.
    Z. Agur, A.S. Fraenkel, S.T. Klein: Disc. Math. 70, 295 (1988).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin, Heidelberg 1989

Authors and Affiliations

  • Z. Agur
    • 1
  1. 1.Dept. of Applied Math. & Computer ScienceThe Weizmann Institute of ScienceRehovotIsrael

Personalised recommendations