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Anaerobic Metabolism Within the Brain: Its Relationship to Brain Failure in Head-Injured Patients

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Book cover Brain Failure

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 9))

Abstract

Anaerobic glycolysis is a characteristic feature of central nervous system ischemic metabolism. With complete cerebral ischemia, such as occurs with cardiac arrest, oxygen supplies are depleted within 30s. Oxidative phosphorylation ceases, but endogenous stores of glucose maintain anaerobic glycolysis for a few moments. The amount of lactic acid accumulation is primarily dependent upon the preischemia tissue glucose stores, which are proportional to the blood glucose concentration. After 2–3 min, ATP stores become depleted, and the adeny-late energy charge reaches minimal values after approximately 5 min.

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Authors
  1. C. S. Robertson
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Editors and Affiliations

  1. Intensive Care Unit, Guy’s Hospital, St. Thomas Street, London, SE1 9RT, UK

    David Bihari

  2. Department of Neuropsychiatry, Walter Reed Army Institute of Research, Washington, DC, 20307, USA

    John W. Holaday

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© 1989 Springer-Verlag Berlin Heidelberg

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Robertson, C.S. (1989). Anaerobic Metabolism Within the Brain: Its Relationship to Brain Failure in Head-Injured Patients. In: Bihari, D., Holaday, J.W. (eds) Brain Failure. Update in Intensive Care and Emergency Medicine, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83929-0_7

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  • DOI: https://doi.org/10.1007/978-3-642-83929-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51655-2

  • Online ISBN: 978-3-642-83929-0

  • eBook Packages: Springer Book Archive

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