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The Role of Lipid Peroxidation in Ischemic Central Nervous System Injury

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Brain Failure

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 9))

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Abstract

The role of lipid peroxidation as a key pathophysiological factor in tissue injury in vivo remains in dispute. Particularly contentious issues concern the initiation of lipid peroxidation and the role of iron in this event. An answer to these issues will depend on the advent of more precise and improved methods of measurement. Until then, evidence to support lipid peroxidation as a mediator of tissue injury will rely largely on current methods of detection and experimental observations that pharmacologie antagonism of oxygen radical generation and/or lipid peroxidation results in a therapeutic effect.

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Authors
  1. E. D. Means
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  2. J. M. Braughler
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  3. E. D. Hall
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Editors and Affiliations

  1. Intensive Care Unit, Guy’s Hospital, St. Thomas Street, London, SE1 9RT, UK

    David Bihari

  2. Department of Neuropsychiatry, Walter Reed Army Institute of Research, Washington, DC, 20307, USA

    John W. Holaday

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© 1989 Springer-Verlag Berlin Heidelberg

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Means, E.D., Braughler, J.M., Hall, E.D. (1989). The Role of Lipid Peroxidation in Ischemic Central Nervous System Injury. In: Bihari, D., Holaday, J.W. (eds) Brain Failure. Update in Intensive Care and Emergency Medicine, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83929-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-83929-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51655-2

  • Online ISBN: 978-3-642-83929-0

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