Abstract
Patients with active acromegaly are characterized by increased plasma volume, sodium retention, increased renal plasma flow and increased glomerular filtration rate [2] as well as hyperinsulinemia and insulin resistance [1]. Moreover, prevalence of hypertension is increased in active acromegaly [4]. Therefore, it appeared worthy of examination whether effects of human atrial natriuretic peptide (human ANF — (99–126), hANP) or any impairment of hANP action might contribute to the pathophysiology of active acromegaly.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Althoff PH, Schmidt K, Hofmeister-Wagner WD, Knigge H, Rosak C, Jungmann E, Schöffling K (1987) Glukosetoleranz unter verschiedenen Pharmakotherapien der Akromegalie — differente Einflüsse von Bromocriptin und einem Somatostatin-Analogon. Akt Endokr Stoffw 8: 193
Falkhed T, Sjögren B (1964) Extracellular fluid volume and renal function in pituitary insufficiency and acromegaly. Acta Endocrinol 46: 80–88
Haak T, Jungmann E, Hannappel B, Schöffling K (1988) Zur Wirkung des humanen atrialen natriuretischen Peptides auf die Glucosetoleranz bei gesunden Probanden. Coll endocrinol südwestdtsch Arbeitsgruppen, Mainz
Hayward RP, Emanuel RW, Nabarro JDN (1986) Acromegalic heart disease: Influence of treatment of the acromegaly on the heart. Quart J Med 237: 41–58
Kühn M, Ammon HPT, Verspohl EJ (1988) Atrial natriuretic peptide acts via specific receptors on cGMP system of rat abstract islets without affecting insulin release. Diabetologia 31: 511A
Richards AM, Nicholls MG, Espiner EA, Ikram H, Yandle TG, Joyce SL, Cullens MM (1985) Effects of alpha-human atrial natriuretic peptide in essential hypertension. Hypertension 7: 812–817
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Jungmann, E., Schirmer, U., Haak, T., Scheuermann, EH., Schöffling, K. (1989). Human Atrial Natriuretic Peptide in Active Acromegaly: Effects on Hormonal, Metabolic, Hemodynamic, and Renal Parameters. In: Kaufmann, W., Wambach, G. (eds) Endocrinology of the Heart. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83858-3_54
Download citation
DOI: https://doi.org/10.1007/978-3-642-83858-3_54
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-51409-1
Online ISBN: 978-3-642-83858-3
eBook Packages: Springer Book Archive