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The Atrial Natriuretic Peptide in Human Hypertension

  • Conference paper
Endocrinology of the Heart

Summary

Measurements by radioimmunoassay of the ANP C-terminal (Ser 99-Tyr 126), N-terminal (Asn 1-Arg 98), and cyclic GMP in plasma of 77 healthy subjects and 32 patients with labile hypertension but with diastolic pressures below 90 mmHg at time of blood sampling, 74 with mild hypertension and diastolic pressures between 90–104 mmHg, 16 with moderate hypertension and diastolic pressures between 105 and 114 mmHg, and 7 with severe hypertension and diastolic pressures above 115 mmHg were found to be within normal range in all groups of patients with untreated essential hypertension. In view of the reported increases in right and left atrial pressures in patients with mild and moderate hypertension, these findings suggest a hyporesponsiveness of the atria to release ANP in essential hypertension.

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References

  1. Genest J, Cantin M (eds) (1988) The atrial natriuretic factor, its physiology and biochemistry. Springer, Berlin Heidelberg New York, pp 1–145

    Google Scholar 

  2. Larochelle P, Cusson JR, Gutkowska J, Schiffrin EL, Hamet P, Kuchel O, Genest J, Cantin M (1987) Plasma concentration of atrial natriuretic factor in essential and renovascular hypertension. Br Med J 294: 1249–1252

    Article  CAS  Google Scholar 

  3. Genest J (1986) The atrial natriuretic factor. Br Heart J 56: 302–316

    Article  PubMed  CAS  Google Scholar 

  4. Genest J, Larochelle P, Cusson JR, Garcia R, Gutkowska J, Cantin M (1988) The atrial natriuretic factor in hypertension. Am J Med Sci 295: 299–304

    Article  PubMed  CAS  Google Scholar 

  5. Tsuchiya S, Ogawa K, Sataka K (1980) Plasma levels of cyclic nucleotides in patients with essential hypertension. Jpn Heart J 21: 803–815

    Article  PubMed  CAS  Google Scholar 

  6. Zachariah PK, Burnett JC, Ritter S, Strong CG (1987) Atrial natriuretic peptide in human essential hypertension. Mayo Clin Proc 62: 782–786

    PubMed  CAS  Google Scholar 

  7. Kohno M, Yasunari K, Matsuura T, Murakama K, Takeda T (1987) Circulating atrial natriuretic polypeptide in essential hypertension. Am Heart J 113: 1160–1163

    Article  PubMed  CAS  Google Scholar 

  8. Nakaoka H, Kitahara Y, Amano M, Imataka K, Fujii J, Ishibashi M, Yamaji T (1987) Effect of 13-adrenergic receptor blockade on atrial natriuretic peptide in essential hypertension. Hypertension 10: 221–225

    PubMed  CAS  Google Scholar 

  9. Naruse N, Naruse K, Obana K, Kurimoto F, Sakurai H, Honda T, Higashida T, Demura H, Inagami T, Shizume K (1986) Immunoreactive alpha-human atrial natriuretic polypeptide in human plasma. Peptides 7: 141–145

    Article  PubMed  CAS  Google Scholar 

  10. Andersson OK, Persson B, Aurell M, Granerus G, Wysocky M, Hedner J, Hedner T (1986) Basal and stimulated levels of immunoreactive atrial natriuretic peptide (ahANP) levels in relation to central venous pressure, renal and central hemodynamics and sodium excretion in normotensive and hypertensive man. J Cardiovasc Pharmacol 8: 1300

    Google Scholar 

  11. Hedner T, Hedner J, Towle AC, Hartford M, Ljiungram S, Wikstrand J, Berglund G (1986) Plasma atrial natriuretic peptide ( ANP) in patients with mild to moderate hypertension. J Cardiovasc Pharmacol 8: 1299

    Google Scholar 

  12. Nishiuchi T, Saito FI, Yanasaki Y, Saito S (1986) Radioimmunoassay for atrial natriuretic peptide: Method and results in normal subjects and patients with various diseases. Clin Chim Acta 159: 45–47

    Article  PubMed  CAS  Google Scholar 

  13. Nozuki M, Mouri T, Itoi K, Takahashi K, Totsune K, Saito T, Yoshinaga K (1986) Plasma concentrations of atrial natriuretic peptide in various diseases. Tohoku J Exp Med 148: 439–447

    Article  PubMed  CAS  Google Scholar 

  14. Yamaji T, Ishibashi M, Sekihara H, Takabu F, Nakaoka H, Fujii J (1986) Plasma levels of atrial natriuretic peptide in primary aldosteronism and essential hypertension. J Clin Endocrin Metab 63: 815–818

    Article  CAS  Google Scholar 

  15. Nilsson P, Lindholm L, Schersten B, Horn R, Melander A, Hesch RD (1987) Atrial natriuretic peptide and blood pressure in a geographically defined population. Lancet 1: 883–885

    Article  Google Scholar 

  16. Sugawara A, Nakao K, Sakamoto M, Morii N, Yamada T, Itoh H, Shiono S, Imura H (1985) Plasma concentration of atrial natriuretic polypeptide in essential hypertension. Lancet 11: 1426–1427

    Article  Google Scholar 

  17. Sugawara A, Nakao K, Kono T, Morii N, Yamada T, Itoh H, Shiono S, Saito Y, Mukoyama M, Arai H, Imura H (1988) Atrial natriuretic factor in essential hypertension and adrenal disorders. Hypertension 11 [Suppl 1]: 212–216

    Google Scholar 

  18. Sagnella GA, Markandu ND, Shore AC, MacGregor GA (1986) Raised circulating levels of atrial natriuretic peptides in essential hypertension. Lancet 1: 179–181

    Article  PubMed  CAS  Google Scholar 

  19. MacGregor GA, Sagnella GA, Markandu ND, Shore AC (1986) Raised plasma levels of atrial natriuretic peptide in untreated essential hypertension. J Cardiovasc Pharmacol 8: 1301

    Article  Google Scholar 

  20. Richards AM, Tonolo G, Davidson G (1986) Plasma atrial natriuretic peptide in essential hypertension. Proceedings, Council for High Blood Pressure Research, American Heart Association, Hypertension 8: 826

    Google Scholar 

  21. Arendt RM, Stangl E, Zahringer J, Liebisch DC, Herz A (1985) Demonstration and characterization of alpha-human atrial natriuretic factor in human plasma. FEBS Lett; 189: 57–61

    Article  PubMed  CAS  Google Scholar 

  22. Iimura O, Shimamoto K, Ando T, Ura N, Ishida H, Nakagawa M, Yokoyama T, Fukuyama S, Yamaguchi Y, Yamaji I (1987) Plasma levels of human atrial natriuretic peptide in patients with hypertensive diseases. Can J Physiol Pharmacol 65: 1701–1705

    Article  PubMed  CAS  Google Scholar 

  23. Wambach G, Bonner S, Stimpel M, Kaufmann W (1988) Relationship between plasma atrial natriuretic peptide and left atrial and left ventricular involvement in essential hypertension. J Hypertens 6: 573–577

    Article  PubMed  CAS  Google Scholar 

  24. Larochelle P, Cusson JR, Thibault G, Hamet P, Genest J, Cantin M (1989) C- and N-terminal fragments of atrial natriuretic factor in essential hypertension. Hypertension (submitted for publication)

    Google Scholar 

  25. Montorsi P, Tonolo G, Polonia J, Hepburn D, Richards AM (1987) Correlates of plasma atrial natriuretic factor in health and hypertension. Hypertension 10: 570–576

    PubMed  CAS  Google Scholar 

  26. Sagnella GA, Markandu ND, Buckley MG, Shore AC, Sugden AL, Singer DRJ, MacGregor GA (1988) Plasma atrial natriuretic peptide in essential hypertension. Am J Hypertens 1: 112–118

    PubMed  CAS  Google Scholar 

  27. Cusson JR, Hamet P, Gutkowska J, Kuchel O, Genest J, Cantin M, Larochelle P (1987) Effects of atrial natriuretic factor in natriuresis and cGMP in patients with essential hypertension. J Hypertens 5: 435–443

    Article  PubMed  CAS  Google Scholar 

  28. Hynynen M, Kupari M, Salmenpera M, Tikkanen I, Heinonen J, Fyhrquist F, Totterman KJ (1988) Hemodynamic effects of alpha-human atrial natriuretic peptide in healthy volunteers. J Cardiovasc Pharmacol 11: 711–715

    Article  PubMed  CAS  Google Scholar 

  29. Weidmann P, Hasler L, Gnädinger MP, Lang RE, Uehlinger DE, Shaw S, Rascher W, Reubi FC (1986) Blood levels and renal effects of atrial natriuretic peptide in normal man. J Clin Invest 77: 734–742

    Article  PubMed  CAS  Google Scholar 

  30. Zimmerman RS, Schirger JS, Edwards BS, Heublein DM, Schwab TR, Burnett JC (1987) Cardiovascular renal responses to physiologic concentrations of atrial natriuretic factor (ANF). J Am Coll Cardiol 9: 242A

    Article  Google Scholar 

  31. London GM, Safar ME, Safar AL, Surion AC (1985) Blood pressure in the “low pressure system” and cardiac performance in essential hypertension. J Hypertens 3: 337–342

    Article  PubMed  CAS  Google Scholar 

  32. Ferlinz J (1980) Right ventricular performance in essential hypertension. Circulation 61: 157–162

    Google Scholar 

  33. Guazzi M, Fiorentini C, Olivari MP, Polese A (1979) Cardiac load and function in hypertension. Am J Cardiol 44: 1007–1012

    Article  PubMed  CAS  Google Scholar 

  34. Olivari MT, Fiorentini C, Polese A, Guazzi MD (1978) Pulmonary hemodynamics and right ventricle function in hypertension. Circulation 57: 1185–1190

    PubMed  CAS  Google Scholar 

  35. Goetz KL (1987) Atrial natriuretic peptide and atrial pressure. N Engl J Med 316: 485

    Article  PubMed  CAS  Google Scholar 

  36. Raine AE, Erne P, Bürgisser E, Müller FB, Bolli P, Burkart F, Bühler FR (1986) Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure. N Engl J Med 315: 533–537

    Article  PubMed  CAS  Google Scholar 

  37. Jin H, Chen YF, Yang RH, Ming QC, Oparil S (1988) Impaired release of atrial natriuretic factor in NaCl-loaded spontaneously hypertensive rats. Hypertension 11: 739–744

    PubMed  CAS  Google Scholar 

  38. Greenwald JE, Sakata M, Michener ML, Sides SD, Needleman P (1988) Is atriopeptin a physiological or pathophysiological substance? Studies in the autoimmune rat. J Clin Invest 81: 1036–1041

    Article  PubMed  CAS  Google Scholar 

  39. Guyton AC, Coleman TG, Young DB, Lohmeier TE, De-Clue JW (1980) Salt-balance and long-term blood pressure control. Ann Rev Med 13: 15–27

    Article  Google Scholar 

  40. Tobian L, Lange J, Magraw S, Coffee K (1974) Body sodium and hypertension, sodium retention by “hypertensive kidneys”. Trans Assoc Am Phys 87: 225–232

    PubMed  CAS  Google Scholar 

  41. Tobian L, Johnson MA, Lange J, Magraw S (1975) Effect of varying perfusion pressures on the output of sodium and renin and the vascular resistance in kidneys of rats with “post-salt” hypertension and Kyoto spontaneous hypertension. Circ Res 36 [Suppl I]: 1162–1170

    Google Scholar 

  42. Genest J, Nowaczynski W, Kuchel O, Boucher R, Rojo-Ortega JM, Constantopoulos G, Ganten D, Messerli F (1976) The adrenal cortex and essential hypertension. Recent Progr Horm Res 32: 377–427

    PubMed  CAS  Google Scholar 

  43. Collins RD, Weinberger MH, Dowdy AJ, Nokes GW, Gonzales CM, Luetscher JA (1970) Abnormally sustained aldosterone secretion during salt-loading in patients with various forms of benign hypertension: Relation to plasma renin activity. J Clin Invest 49: 1415–1426

    Article  PubMed  CAS  Google Scholar 

  44. Luetscher J, Beckerhoff R, Dowdy AJ, Wilkinson R (1972) Incomplete suppression of aldosterone secretion and plasma concentration in hypertensive patients on high sodium intake. In: Genest J, Koiw E (eds) Hypertension ’72. Springer, Berlin Heidelberg New York, pp 286–292

    Google Scholar 

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Author information

Authors and Affiliations

  1. Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada

    J. Genest, P. Larochelle, J. R. Cusson & M. Cantin

Authors
  1. J. Genest
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  2. P. Larochelle
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  3. J. R. Cusson
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  4. M. Cantin
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Editor information

Editors and Affiliations

  1. Medizinische Klinik II und Poliklinik der Universität, Ostmerheimer Straße 200, D-5000, Köln 91, Germany

    W. Kaufmann  & G. Wambach  & 

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Genest, J., Larochelle, P., Cusson, J.R., Cantin, M. (1989). The Atrial Natriuretic Peptide in Human Hypertension. In: Kaufmann, W., Wambach, G. (eds) Endocrinology of the Heart. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83858-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-83858-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51409-1

  • Online ISBN: 978-3-642-83858-3

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