Skip to main content
SpringerLink
Log in

Basic and Clinical Relevance of Hormonal Influence in Breast Cancer

  • Conference paper
Hormone-Related Malignant Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 118))

  • 33 Accesses

Abstract

In the Federal Republic of Germany breast cancer has a leading place among malignant tumors in women. Genital and breast cancers account for 32% of all female deaths from malignant neoplasias. The distribution of types of cancer is as follows: breast 52%, uterine cervix 9%, corpus uteri 4.5%, adnexae 19%, and other sex organs 15.5% (Maas and Sachs 1972; Schmidt-Matthiesen 1975, Vorherr 1980). Besides general epidemiological factors such as geographical distribution, dietary factors, age distribution, familial disposition, and socioeconomic influences, possible hormonal components are discussed in connection with the etiology of breast cancer (Fischedick and Lux 1977; Henderson et al. 1974; Lilienfeld 1963, Maass et al. 1970; MacMahon et al. 1973; De Waard 1969; Wynder et al. 1960; Waterhouse et al. 1976; Anderson 1974; Carroll et al. 1968; Thijssen 1968; Lewison 1976; Centers for Disease Control Cancer and Steroid Hormone Study 1983; Thomas 1984; Ketcham and Sindelar 1975). For example, an early menarche or a late menopause leads to an increased incidence of breast cancer, bilateral ovariectomy before the 40th year of life reduces the risk of breast cancer, and childlessness is regarded as a risk factor for breast cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adami HO, Rimsten A, Thoren L, Vegelius J, Wide L (1978) Thyroid disease and function in breast cancer patients and non-hospitalized controls evaluated by determination of TSH, T3, rT3 T4 levels in serum. Acta Chir Scand 144: 89–97

    PubMed  CAS  Google Scholar 

  • Anderson DE (1974) Genetic study of breast cancer: identification of a high risk group. Cancer 34: 1090–1097

    Article  PubMed  CAS  Google Scholar 

  • Baulieu EE, Atger M, Best-Belpomme M, Corvol P, Courvalin JL, Mester J, Milgrom E, Robel P, Rochefort H, Catalogne D (1975) Steroid hormone receptors. Vitam Horm 33: 649–736

    Article  PubMed  CAS  Google Scholar 

  • Baxter JD, Funder JW (1979) Hormone receptors. N Engl J Med 301: 1149–1161

    Article  PubMed  CAS  Google Scholar 

  • Beck T, Pollow K, Heubner A (1986) Monoklonale Antikörper zum immunhistochemis- chen Nachweis des Östrogenrezeptor-Status am Gewebeschnitt primärer Mammakarzin-orne. Geburtshilfe Frauenheilkd 46: 450–454

    Article  Google Scholar 

  • Bloom HJG, Richardson WW (1957) Histological grading and prognosis in breast cancer. Br J Cancer 11: 359–363

    Article  PubMed  CAS  Google Scholar 

  • Blossey HC, Bartsch HH, Kanne D, Köbberling J, Nagel GA (1982a) The pharmacokinetics of high-dose medroxyprogesterone acetate ( MPA) in the therapy of advanced breast cancer. Cancer Chemother Pharmacol 8: 77–81

    Google Scholar 

  • Blossy HC, Wander HE, Nagel GA, Köbberling J. Kleeberg U (1982b) Medroxyprgesteronazetat in hoher Dosierung beim metastasierenden Mammakarzinom. Vergleichende Klinik, Pharmakokinetik und Pharmakodynamik verschiedener Applikationsformen. Onkologie 5: 13–24

    Google Scholar 

  • Carroll KK, Gammal EB, Plunkett ER (1968) Dietary fat and mammary cancer. Can Med Assoc J 98: 590–594

    PubMed  CAS  Google Scholar 

  • Centers for Disease Control Cancer and Steroid Hormone Study (1983) Long-term oral contraceptive use and the risk of breast cancer. JAMA 249: 1591–1595

    Article  Google Scholar 

  • Chamness GC, McGuire WL (1979) Scatchard plots: common errors in correction and interpretation. Steroids 26: 538–542

    Article  Google Scholar 

  • Chopra IJ, Chopra SR, Smith SR, Teza M, Salomon DS (1975) Reciprocal changes in serum concentrations of 3,3’,5’,-triiodothryonine (reverse T3) and 3,3’,5-triiodothyronine (T3) in systemic illnesses. J Clin Endocrinol Metab 41: 1043–1049

    Article  PubMed  CAS  Google Scholar 

  • Clark JH, Peck EJ (eds) (1979) Female sex steroids, receptors and function, Morogr Endocrinol 14

    Google Scholar 

  • De Waard F (1969) The epidemiology of breast cancer. Review and prospects. Int J Cancer 4: 677–586

    Google Scholar 

  • Fischedick O, Lux H (1977) Zur Epidemiologie des weiblichen Brustkrebses. Gynäkologe 10: 123–128

    Google Scholar 

  • Grandies P, Puri RK, Toft DO (1982). A new affinity design for purification of non-transformed avian progesterone receptor. Endocrinology 110: 1055–1057

    Article  Google Scholar 

  • Grill HJ, Manz B, Pollow K (1982) Double-labeling assay system for estrogen and progesterone receptors. Lancet I: 679

    Google Scholar 

  • Grill HJ, Manz B, Belovsky O, Pollow K (1982) Criteria for the establishment of a double-labeling assay for silmutaneous determination of estrogen and progesterone receptors. Oncology 41: 25–32

    Article  Google Scholar 

  • Grill HJ, Möbius U, Manz B, Pollow K (1983) 16a-Iodo-3,17ß-estradiol: a stable ligand for estrogen receptor determinations in tissues with high 17ß-hydroxysteroid dehydrogenase activity. J Steroid Biochem 19: 1687–1688

    Google Scholar 

  • Grill HJ, Manz B, Belovsky O, Pollow K (1985) Criteria for the establishment of a double-labeling assay for simultaneous determination of estrogen and progesterone receptors. Counting Exchange 1: 1–7

    Google Scholar 

  • Grill HJ, Heubner A, Manz B, Kreienberg R, Pollow K (1985) Charakterisierung der gestagenen und glucocorticoiden Wirkung von MPA auf der Rezeptorebene. In: Nagel GA, Schulz KD, Kreienberg R, Pollow K (eds) Neue Erkenntnisse über den Wirkungsmechanismus von Medroxyprogesteronazetat. Aktuel Onkologie 30: 15–31

    Google Scholar 

  • Guthrie D (1982) Treatment of carcinoma of the cervix with bromocriptine. Br J Obstet Gynaec 98: 853–855

    Article  Google Scholar 

  • Henderson BE, Powell D, Rosario I, Keys C, Hanisch R, Young M, Casagrande J, Gerkins V, Pike MC (1974) An epidemiologic study of breast cancer. J Natl Cancer Inst 53: 609–614

    PubMed  CAS  Google Scholar 

  • Hesch RD (1981) Das Niedrig—T3—Syndrom. Dtsch Med Wochenschr 106: 971–972

    Article  PubMed  CAS  Google Scholar 

  • Heubner A, Manz B, Grill HJ, Pollow K (1984) High-Performance and ion-exchange chromatography and chromatofocusing of the human uterine progesterone receptor: its application to the identification of 21–3H-dehydro Org2058-labelled receptor. J Chromatogr 297: 301–311

    Article  PubMed  CAS  Google Scholar 

  • Heubner A, Belovsky O, Grill Hi, Pollow K (1985) FPLC-Eine neue Dimension in der Analytik und präparativen Darstellung von Progesteron-Rezeptoren. In: FPLC-Fast Protein Liquid Chromatography. GIT, Darmstadt, pp 89–107

    Google Scholar 

  • Heubner A, Beck T, Grill HJ, Pollow K (1986) Comparison of immunocytochemical estrogen receptor assay, estrogen receptor enzyme immunoassay, and radioligand-labeled estrogen receptor assay in human breast cancer and uterine tissue. Cancer Res [Suppl] 46: 4281–4285

    Google Scholar 

  • Hochberg RB (1979) Iodine-25-labeled estradiol: a gamma-emmiting analog of estradiol that binds to the estrogen receptors. Science 205: 1138–1140

    Article  PubMed  CAS  Google Scholar 

  • Hochberg RB, Rosner W (1980) Interaction of 16a(125I)-ß-iodoestradiol with estrogen receptor and other binding proteins. Proc Natl Acad Sci USA 77: 328–332

    Article  PubMed  CAS  Google Scholar 

  • Izuo M, Lino Y, Tominaga T, Nomura Y, Abe D, Enomoto K, Takatani, O, Kubo K (1982) Hochdosierte orale. Therapie mit Medroxyprogesteron-Azetat beim fortgeschrittenen Brustkrebs: Klinische und endokrinologische Untersuchungen. Med Klin SoNr 2: 23–28

    Google Scholar 

  • Jensen EV, De Sombre ER (1972) Mechanism of action of the female sex hormones. Annu Rev Biochem 41: 203–230

    Article  PubMed  CAS  Google Scholar 

  • Jensen EV, Block GE, Smith S (1971) Estrogen receptors and breast cancer response to adrenalectomy. NCI Monogr 34: 55–70

    CAS  Google Scholar 

  • Jonat W, Knapp W, Schumann B, Trapp H, Vanhecke C, Maass H (1984) Orale hochdosierte Gestagntherapie als Versagerschema beim metastasierenden Mammakarzinom. Dtsch Med Wochenschr 109: 46–49

    Article  PubMed  CAS  Google Scholar 

  • Jonat W, Stegner HE, Maass H (1985) Immunhistochemische Bestimmung von Östrogenrezeptoren im Mammakarzinomgewebe mittels monoklonaler Antikörper-erste klinische Ergebnisse. Geburtshilfe Frauenheilkd 45: 473–476

    Article  PubMed  CAS  Google Scholar 

  • Judd Si, Rakoff JS, Yen SSC (1978) Inhibition of gonadotropin and prolactin release by dopamine: effect of endogenous estradiol level. J Clin Endocrinol Metab 47: 494–498

    Article  PubMed  CAS  Google Scholar 

  • Jungblut PW, Hughes S, Hughes A, Wagner RK (1972) Evaluation of various methods for assay of cytoplasmic estrogen receptors in extracts of calf uteri and human breast cancers. Acta Endocrinol 70: 185–195

    PubMed  CAS  Google Scholar 

  • Katzenellenbogen BS (1980) Dynamics of steroid hormone receptor action. Annu Rev Physiol 42: 1–357

    Article  Google Scholar 

  • Ketcham AS, Sindelar WF (1975) Risk factors in breast cancer. Prog Clin Cancer 6: 99–114

    PubMed  CAS  Google Scholar 

  • King RJB (1976) Intracellular reception of steroid hormones. In: Campbell PN, Aldridge WNA (eds) Essays in biochemistry, vol 12. Academic, London, pp 41–46

    Google Scholar 

  • Köhler G, Bässler R (1986) Ergebnisse vergleichender immunhistochemischer und bio-chemischer Untersuchungen zum Östrogen-Rezeptor-Status in Mammakarzinomen. Dtsch Med Wochenschr 111: 1954–1960

    Article  PubMed  Google Scholar 

  • Kolodny RC, Jacobs LS, Daughaday WH (1972) Mammary stimulation causes prolactin secretion in non-lactating women. Nature 238: 284–286

    Article  PubMed  CAS  Google Scholar 

  • Korenman SG, Dukes BA (1970) Specific estrogen binding by the cytoplasm of human breast carcinoma. J Clin Endocrinol Metab 30: 639–645

    Article  PubMed  CAS  Google Scholar 

  • Kreineberg R, Grill HJ, Melchert F, Pollow K (1985) Hochdosierte MPA-Therapie beim metastasierenden Mammakarzinom: MPA-Serumspiegel und hormonelle Parameter. In: Nagel GA, Schulz KD, Kreienberg R, Pollow K (eds) Neue Erkenntnisse über den Wirkungsmechanismus von Medroxyprogesteronazetat. Aktuel Onkologie 30: 65–77

    Google Scholar 

  • Kucera H, Smekal G, Spona J (1983) Prolactin level and cervical carcinoma. J Steroid Biochem 19 [suppl]: 144 S

    Google Scholar 

  • Lessey BA, Alexander PS, Horwitz KB (1983) The subunit structure of human breast cancer progesterone receptors: characterization by chromatography and photoaffinity labeling. Endocrinology 112: 1267–1274

    Article  PubMed  CAS  Google Scholar 

  • Lewison EF (1976) Role of exogenous Estrogenes. In: Stoll BA (ed) Risk factors in breast cancer. Heinemann, London, p 67

    Google Scholar 

  • Lilienfeld AM (1963) The epidemiology of breast cancer. Cancer Res 23: 1503–1513

    PubMed  CAS  Google Scholar 

  • Maass H, Trams G, Sachs H (1970) Das Mammacarcinom. Epidemiologie und Endokrinologie. Gynäkologe 3: 2–6

    Google Scholar 

  • Maass H, Jonat W (1979) Steroidhormonrezeptoren in Mammakarzinomen. Bericht über ein Consensus-Meeting im National Institute of Health, Bethesda USA. Geburtshilfe Frauenheilkd 39: 761–764

    Google Scholar 

  • Maass H, Sachs H (1972) Epidemiologie des Mammacarcinoms. Internist (Berlin) 13: 326–331

    CAS  Google Scholar 

  • MacMahon B, Cole P, Brown J (1973) Etiology of human breast cancer: a review. J Natl Cancer Inst 50: 21–42

    PubMed  CAS  Google Scholar 

  • Mahlke M, Grill HJ, Knapstein P, Wiegand U, Pollow K (1985) Oral high-dose medroxyprogesterone acetate (MPA) treatment: cortisol/MPA serum profiles in relation to breast cancer regression. Oncology 42: 144–149

    Article  PubMed  CAS  Google Scholar 

  • Malarkey WB, Kennedy M, Allred LE, Milo G (1983) Physiological concentrations of prolactin can promote the growth of human breast tumor cells in culture. J Clin Endocrinol Metab 56: 673–677

    Article  PubMed  CAS  Google Scholar 

  • McGuire WL (1979) Assays for estrogen and progesterone receptors in human breast cancer tissue. Applications Data, Beckman Instruments, Spinco Division, Palo Alto

    Google Scholar 

  • McGuire WL, Carbone PP, Vollmer EP (1975) Estrogen receptors in human breast cancer. Raven, New York

    Google Scholar 

  • Meinhold H (1977) Reverses Trijodthyronin-Neue Aspekte des peripheren Metabolismus der Schilddrüsenhormone. Compact News Nucl Med 4: 55–59

    Google Scholar 

  • Noel GL, Suh HK, Frantz AG (1974) Prolactin release during nursing and breast stimulation in post-partum and non—post—partum subjects. J Clin Endocrinol Metab 38: 413–423

    Article  PubMed  CAS  Google Scholar 

  • O’Malley BW, McGuire WL (1968) Studies on the mechanism of action of progesterone in regulation of the synthesis of specific proteins. J Clin Invest 47: 654–664

    Article  PubMed  Google Scholar 

  • Pollow K (1983) Die Bedeutung von Hormonrezeptoren für die Behandlung maligner Erkrankungen. Therapiewoche 33: 6809–6825

    CAS  Google Scholar 

  • Pollow K, Kreienberg R, Grill HJ, Melchert F, Knapstein P, Manz B (1984) Hochdosierte Medroxyprogesteronacetat-Therapie beim metastasierten Mamma-Karzinom in Abhängigkeit von der Applikationsform. In: Robustelli Della Cuna G, Nagel GA, Lanius P (eds) Deutsch-Italienisches Onkologisches Symposium. Kehrer, Freiburg, pp 85–100

    Google Scholar 

  • Possinger K, Willich S, Jaspers L, Langecker P. Schmid L, Wilmanns W (1985) Therapeutische Effektivität einer hochdosierten MPA-Therapie und Wirkung auf das endokrine System. In: Nagel GA, Schulz KD, Kreienberg R, Pollow K (eds) Neue Erkenntnisse über den Wirkungsmechanismus von Medroxyprogesteronazetat. Aktuel Onkologie 30: 15–31

    Google Scholar 

  • Press MF, Greene GL (1984) Methods in laboratory investigations. An immunocytochemical method for demonstrating estrogen receptor in human uterus using monoclonal antibodies to human estrophilin. Lab Invest 50: 480–486

    Google Scholar 

  • Raynaud JP (1977) R5020, a tag for the progesterone receptor. In: McGuire WL, Raynaud JP, Baulieu EE (eds) Progesterone receptors in normal and neoplastic tissues. Raven, New York, pp 9–21

    Google Scholar 

  • Rees LH, Bloomfield GA, Rees GM, Corrin B, Franks LM, Ratcliffe JG (1974) Multiple hormones in a bronchial tumor. J Clin Endcrinol Metab 38: 1090–1097

    Article  CAS  Google Scholar 

  • Reiner A, Reiner G, Spona J, Schemper M, Kolb R, Jakesz R, Holzner JH (1986) Vergleich von immunochemischem und biochemischem Ostrogenrezeptor-Nachweis bei Mammakarzinomen und Beziehung zur histochemischen Tumorklassifikation. Verh Dtsch Ges Pathol 70: 243–246

    PubMed  CAS  Google Scholar 

  • Remmele W, Stegner HE (1987) Immunhistochemischer Nachweis von Östrogenrezeptoren (ER-ICA) im Mammakarzir_omgewebe: Vorschlag zur einheitlichen Bewertung des Untersuchungsbefundes. Frauenarzt 28: 41–43

    Google Scholar 

  • Rose DP, Davis TE (1978) Plasma thyroid-stimulating hormone and thyroxine concentrations in breast cancer. Cancer 41: 666–669

    Article  PubMed  CAS  Google Scholar 

  • Rose DP, Davis TE (1979) Plasma triiodthyronine concentrations in breast cancer. Cancer 43: 1434–1438

    Article  PubMed  CAS  Google Scholar 

  • Salimtschik M, Mouridsen HT, Loeber J, Johansson (1980) Comparative pharmacokinetics of medroxyprogesterone acetate administered by oral and intramuscular routes. Cancer Chemother Pharmacol 4: 267–269

    CAS  Google Scholar 

  • Scatchard DG (1949) The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51: 660–672

    Article  CAS  Google Scholar 

  • Schmidt-Matthiesen H (1975) Der Internist und das Genital-und Brustcarcinom der Frau. Die Krebssuche in der internistischen Praxis. Internist 16: 223–231

    PubMed  CAS  Google Scholar 

  • Schrader WT, Kuhn RW, O’Malley BW (1977) Progesterone-binding components of chick oviduct. Receptor B subunit protein purified to appanent homogeneity from laying hen oviducts. J Biol Chem 252: 299–307

    Google Scholar 

  • Sherman MR, Tuazon FB, Diaz SC, Miller LK (1976) Multiple forms of oviduct progesterone receptors analyzed by ion exchange filtration and gel electrophoresis. Biochemistry 15: 980–989

    Article  PubMed  CAS  Google Scholar 

  • Smith RG, D’Istria M, Nguyen TV (1981) Purification of a human progesterone receptor. Biochemistry 20: 5557–5565

    Article  PubMed  CAS  Google Scholar 

  • Tamassia V (1986) Clinical pharmacokinetics of medroxyprogesterone acetate: relevance for the treatment of breast and endometrial cancer. In: Bolla M, Racinet C, Vrousos C (eds) Endometrial cancers. Karger, Basel, PP 168–176

    Google Scholar 

  • Thijssen H (1968) Steroid excretion patterns in postmenopausal women. Kanker Jaarboek 18: 171–183

    Google Scholar 

  • Thomas DB (1984) Do hormones cause breast cancer? Cancer 53 [Suppl]: 3

    Article  Google Scholar 

  • Toft DO, Gorski JA (1966) A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization. Proc Natl Acad Sci USA 55: 1574–1581

    Article  PubMed  CAS  Google Scholar 

  • Turkington RW (1971) Ectopic production of prolactin. N Engl J Med 285: 1455–1458

    Article  PubMed  CAS  Google Scholar 

  • Vekemans M, Delvoye, L’Hermite M, Robyn C (1977) Serum prolactin levels during the menstrual cycle. J Clin Endocrinol Metab 44: 1222–1225

    Google Scholar 

  • Von Werder K, Rjosk HK (1979) Menschliches Prolaktin. Klin Wochenschr 57: 1–12

    Article  Google Scholar 

  • Von Werder K, Fahlbusch R, Rjosk HK (1977) Hyperprolaktinämie. Pathophysiologie, klinische Bedeutung, Therapie. Internist 18: 520–582

    Google Scholar 

  • Vorherr H (1980) Breast cancer. Urban and Schwarzenberg, Baltimore

    Google Scholar 

  • Wagner RK, Jungblut PW (1976) Estradiol and dihydrotestosterone receptors in normal and neoplastic mammary tissue. Acta Endocrinol 82: 105–120

    PubMed  CAS  Google Scholar 

  • Wander HE, Blossey HCh, Köbberling J, Nagel GA (1983) Hochdosiertes MPA beim metastasierten Mammakarzinom. Beziehung zwischen Krankheitsverlauf und Hormonprofilen. Klin Wochenschr 61: 553–560

    Article  PubMed  CAS  Google Scholar 

  • Waterhouse J, Muir C, Correa P, Powell J (1976) Cancer incidence in five continents. IARC III, Lyon

    Google Scholar 

  • Wrange O, Nordensköld B, Silfverswärd C, Ganberg PO, Gustafsson JA (1976) Isoelectric focusing of estradiol receptor protein from human mammary —a comparison to sucrose gradient analysis. Eur J Cancer 12: 695–700

    Article  PubMed  CAS  Google Scholar 

  • Wrange Ö, Nordenskjöld B, Gustafsson JA (1978) Cytosol estradiol receptor in human mammary carcinoma: an assay based on isoelectric focusing in polyacrylamide gel. Anal Biochem 85: 461–475

    Article  PubMed  CAS  Google Scholar 

  • Wynder EL, Bross IJ, Hirayama (1960) A study of the epidemiology of cancer of the breast. Cancer 13: 559–601

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für Experimentelle Endokrinologie, Frauenklinik, Johannes-Gutenberg-Universität, Langenbeckstraße 1, 6500, Mainz, Germany

    K. Pollow, H.-J. Grill, R. Kreienberg, T. Beck & B. Manz

  2. St. Josefs-Hospital, Salusstraße 15, 6200, Wiesbaden, Germany

    G. Hoffmann

  3. Schering AG, Müllerstraße, 1000, Berlin, Germany

    K. Schmidt-Gollwitzer

Authors
  1. K. Pollow
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H.-J. Grill
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Kreienberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Hoffmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Beck
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Schmidt-Gollwitzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. B. Manz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Frauenklinik, Medizinische Einrichtungen, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, Germany

    Lutwin Beck

  2. Gerhard Domagk-Institut für Pathologie, Westfälische Wilhelms-Universität Münster, Domagkstraße 17, 4400, Münster, Germany

    Ekkehard Grundmann

  3. Urologische Klinik, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, Germany

    Rolf Ackermann

  4. Chirurgische Klinik und Poliklinik I, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, Germany

    Hans-Dietrich Röher

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin·Heidelberg

About this paper

Cite this paper

Pollow, K. et al. (1990). Basic and Clinical Relevance of Hormonal Influence in Breast Cancer. In: Beck, L., Grundmann, E., Ackermann, R., Röher, HD. (eds) Hormone-Related Malignant Tumors. Recent Results in Cancer Research, vol 118. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83816-3_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83816-3_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83818-7

  • Online ISBN: 978-3-642-83816-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation