Abstract
Previously we reported a novel cell line, KM-H2, established from the pleural effusion of a patient who was initially diagnosed as having Hodgkin’s of mixed cellular type (Kamesaki et al. 1986). We describe here the results of further investigation of this line (ultrastructural, immunological, and molecular genetic studies) and discuss its cellular origin. Based on these analyses of the KM-H2 line, as well as those of other cell lines derived from Reed-Sternberg and Hodgkin cells (e.g., L428, L540), we propose a new hypothesis for the cellular origin of Hodgkin’s disease.
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© 1989 Springer-Verlag Berlin · Heidelberg
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Kamesaki, H., Fukuhara, S., Uchino, H., Nosaka, T. (1989). A New Hypothesis on the Cellular Origin of Reed-Sternberg and Hodgkin Cells Based on the Immunological and Molecular Genetic Analysis of the KM-H2 Line. In: Diehl, V., Pfreundschuh, M., Loeffler, M. (eds) New Aspects in the Diagnosis and Treatment of Hodgkin’s Disease. Recent Results in Cancer Research, vol 117. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83781-4_9
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DOI: https://doi.org/10.1007/978-3-642-83781-4_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83783-8
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