Theoretical Models of Cellular Radiation Action

Abstract

This chapter describes some of the theoretical approaches to describe quantitatively the action of radiation on cells. The aim of these attempts is not predominantly to bring radiation biology from a descriptive to a higher theoretical level but more to allow estimates in dose ranges where direct experimental determinations are not feasible or even possible. A well known and important example is the behaviour at very low doses and dose rates. All models may be roughly grouped into two categories: in the first, the emphasis is laid on the distribution of initial lesions and their interactions, while in the second, repair and its efficiency are the focal points. Examples of both types are given.