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Radionuclide Assessment of Diastolic Function in Hypertrophic Cardiomyopathy: Relation to Symptoms and Prognosis

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Advances in Cardiomyopathies

Abstract

In hypertrophic cardiomyopathy (HCM), abnormal left ventricular diastolic function is considered to be important as a pathophysiologic mechanism [1–3]. There are, however, very few reports which evaluate the relation between diastolic function and prognosis. The purpose of the present study was to evaluate the prognostic implications of diastolic dysfunction derived from equilibrium radionuclide angiography and to compare the significance of these diastolic indices with well-recognized risk factors for an adverse prognosis in HCM.

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References

  1. Goodwin JF (1982) The frontiers of cardiomyopathy. Br Heart J 48: 1–18

    Article  PubMed  CAS  Google Scholar 

  2. Wigle ED (1987) Hypertrophic cardiomyopathy: a 1987 viewpoint. Circulation 75: 311–322

    Article  PubMed  CAS  Google Scholar 

  3. Maron BJ, Bonow RO, Cannon RO, Leon MB, Epstein SE (1987) Hypertrophic cardiomyopathy: interrelations of clinical manifestations, pathophysiology, and therapy. N Engl J Med 316:780–789, 844–852

    Article  PubMed  CAS  Google Scholar 

  4. Braunwald E, Lambrew CT, Rockoff SD, Ross J Jr, Morrow AC (1964) Idiopathic hypertrophic subaortic stenosis. I. A description of the disease based upon an analysis of 64 patients. Circulation 30 [Suppl IV]: 3–119

    PubMed  Google Scholar 

  5. Shapiro LM, McKenna WJ (1983) Distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy: a two-dimensional echocardiographic study. J Am Coll Cardiol 2: 437–444

    Article  PubMed  CAS  Google Scholar 

  6. Thrall JH, Freitas JE, Swanson D, Rogers WL, Clare JM, Brown ML, Pitt B (1978) Clinical comparison of cardiac blood pool visualization with technetium-99m red cells labeled in-vivo and with technetium-99m human serum albumin. J Nucl Med 19: 796–803

    PubMed  CAS  Google Scholar 

  7. Sugrue DD, McKenna WJ, Dickie S, Oakley CM, Myers MJ, Lavender JP (1983) Equilibrium radionuclide assessment of left ventricular ejection and filling. Comparison of list-mode and multigated frame-mode measurements. Nucl Med Commun 4: 323–334

    Article  Google Scholar 

  8. Bacharach SL, Green MV, Borer JS, Hyde JE, Farkas SP, Johnston GS (1979) Left ventricular peak ejection rate, filling rate, and ejection fraction: frame rate requirements at rest and exercise. J Nucl Med 20: 189–193

    Google Scholar 

  9. Bonow RO, Rosing DR, Bacharach SL, Green MV, Kent KM, Lipson LC, Maron BJ, Leon MB, Epstein SE (1981) Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. Circulation 64: 787–796

    Article  PubMed  CAS  Google Scholar 

  10. Spirito P, Maron BJ, Bonow RO (1986) Noninvasive assessment of left ventricular diastolic function: comparative analysis of Doppler echocardiographic and radionuclide angiographic techniques. J Am Coll Cardiol 7: 518–526

    Article  PubMed  CAS  Google Scholar 

  11. Betocchi S, Bonow RO, Bacharach SL, Rosing DR, Maron BJ, Green MV (1986) Isovolumic relaxation period in hypertrophic cardiomyopathy: assessment by radionuclide angiography. J Am Coll Cardiol 7: 74–81

    Article  PubMed  CAS  Google Scholar 

  12. Bonow RO, Frederick TM, Bacharach SL, Green MV, Goose PW, Maron BJ, Rosing DR (1983) Atrial systole and left ventricular filling in hypertrophic cardiomyopathy: effect of verapamil. Am J Cardiol 51: 1386–1391

    Article  PubMed  CAS  Google Scholar 

  13. Bonow RO, Dilsizian V, Rosing DR, Maron BJ, Bacharach SL, Green MV (1985) Verapamil-induced improvement in left ventricular diastolic filling and increased exercise tolerance in patients with hypertrophic cardiomyopathy: short- and long-term effects. Circulation 72: 853–864

    Article  PubMed  CAS  Google Scholar 

  14. Newman H, Sugrue DD, Oakley CM, Goodwin JF, McKenna WJ (1985) Relation of left ventricular function and prognosis in hypertrophic cardiomyopathy: an angiographic study. J Am Coll Cardiol 5: 1064–1074

    Article  PubMed  CAS  Google Scholar 

  15. Maron BJ, Roberts WC, Epstein SE (1982) Sudden death in hypertrophic cardiomyopathy: a profile of 78 patients. Circulation 65: 1388–1394

    Article  PubMed  CAS  Google Scholar 

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© 1990 Springer-Verlag Berlin Heidelberg

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Chikamori, T., Dickie, S., Counihan, P.J., Poloniecki, J.D., McKenna, W.J. (1990). Radionuclide Assessment of Diastolic Function in Hypertrophic Cardiomyopathy: Relation to Symptoms and Prognosis. In: Baroldi, G., Camerini, F., Goodwin, J.F. (eds) Advances in Cardiomyopathies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83760-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-83760-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83762-3

  • Online ISBN: 978-3-642-83760-9

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