Long-Term Treatment with Amiodarone for the Prevention of Sudden Death in Patients with Dilated Cardiomyopathy

  • M. Ciaccheri
  • G. Castelli
  • M. Nannini
  • V. Troiani
  • C. Arcangeli
  • P. Marconi
  • A. Dolara
Conference paper


There is considerable controversy about the treatment of asymptomatic ventricular arrhythmias in patients with congestive heart failure [1]. Antiarrhythmic therapy has been reported either to prolong survival and decrease the incidence of sudden death (SD) [2], or only to reduce mortality [3]. Patients with dilated cardiomyopathy (DC) and complex ventricular arrhythmias have been treated successfully with amiodarone and no patient has died suddenly during therapy [4]. Others have underlined that the evidence for results is still lacking [5]. We report the results of our study on the efficacy of amiodarone for the prevention of SD in patients with DC and ventricular tachycardia (VT).


Ventricular Tachycardia Ventricular Arrhythmia Dilate Cardiomyopathy Idiopathic Dilate Cardiomyopathy Complex Ventricular Arrhythmia 
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  1. 1.
    Francis GS (1988) Should asymptomatic ventricular arrhythmias in patients with congestive heart failure be treated with antiarrhythmic drugs? J Am Coll Cardiol 12: 274–283PubMedCrossRefGoogle Scholar
  2. 2.
    Simonton CA, Daly PA, Kereiakes D, Modin G, Chatterjee K (1987) Survival in severe left ventricular failure treated with the new nonglycosidic, nonsympathomimetic oral inotropic agents. Chest 92: 118–123PubMedCrossRefGoogle Scholar
  3. 3.
    Dargie HJ, Cleland JGF, Leckie BJ, Inglis CG, East BW, Ford I (1987) Relation of arrhythmias and electrolyte abnormalities to survival in patients with severe chronic heart failure. Circulation [Suppl 4]: 98–107Google Scholar
  4. 4.
    Neri R, Mestroni L, Salvi A, Pandullo C, Camerini F (1987) Ventricular arrhythmias in dilated cardiomyopathy: efficacy of amiodarone. Am Heart J 113: 707–715PubMedCrossRefGoogle Scholar
  5. 5.
    Schmitt C, Brachmann J, Waldecker B, Rizos I, Senges J, Kubler W (1987) Amiodarone in patients with recurrent sustained ventricular tachyarrhythmias: results of programmed electrical stimulation and long-term clinical outcome in chronic treatment. Am Heart J 114: 279–283PubMedCrossRefGoogle Scholar
  6. 6.
    Goodwin JF, Oakley CM (1972) The cardiomyopathies. Br Heart J 34: 545PubMedCrossRefGoogle Scholar
  7. 7.
    Feigenbaum H (1986) Echocardiography, 4th edn. Lea and Febiger, PhiladelphiaGoogle Scholar
  8. 8.
    Meinertz T, Hofmann T, Kasper W, Treese N, Bechtold H, Stienen U, Pop T, Leitner ER, Andresen D, Meyer J (1984) Significance of ventricular arrhythmias in idiopathic dilated cardiomyopathy. Am J Cardiol 51: 507–512Google Scholar
  9. 9.
    Huang SK, Messer JV, Denes P (1983) Significance of ventricular tachycardia in idiopathic dilated cardiomyopathy: observations in 35 patients. Am J Cardiol 51: 507–512PubMedCrossRefGoogle Scholar
  10. 10.
    Olshausen KV, Shaper A, Mehmel HC, Schwarz F, Senges J, Kubler W (1984) Ventricular arrhythmias in idiopathic dilated cardiomyopathy. Br Heart J 51: 195–201CrossRefGoogle Scholar
  11. 11.
    Chakko CS, Gheorghiade M (1985) Ventricular arrhythmias in severe heart failure: incidence, significance and effectiveness of antiarrhythmic therapy. Am Heart J 109: 497–504PubMedCrossRefGoogle Scholar
  12. 12.
    Maskin CS, Siskind SJ, Le Jemtel TH (1984) High prevalence of sustained ventricular tachycardia in severe congestive heart failure. Am Heart J 107: 896–901PubMedCrossRefGoogle Scholar
  13. 13.
    Follansbee WP, Michelson EL, Morganroth J (1980) Non-sustained ventricular tachycardia in ambulatory patients: characteristics and association with sudden cardiac death. Ann Intern Med 92: 741–747PubMedGoogle Scholar
  14. 14.
    Heger JJ, Prystowsky EL, Jackmann WM, Naccarelli SV, Warfei KA, Ruikenberger RL, Zipes DP (1981) Amiodarone: clinical efficacy and electrophysiology during long- term therapy for recurrent ventricular tachycardia or ventricular fibrillation. N Engl J Med 305: 539–545PubMedCrossRefGoogle Scholar
  15. 15.
    Morady F, Sauve MJ, Malone P, Shen EN, Schwartz AB, Bhandari A, Keung E, Sung RJ, Scheinmann MM (1983) Long-term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation. Am J Cardiol 52: 975–979PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. Ciaccheri
  • G. Castelli
  • M. Nannini
  • V. Troiani
  • C. Arcangeli
  • P. Marconi
  • A. Dolara

There are no affiliations available

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