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Evolution of Left Ventricular Hypertrophy in Patients with Hypertrophic Cardiomyopathy

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Advances in Cardiomyopathies

Abstract

Application of echocardiography to cardiac diagnosis in the 1970s represented a major advance in the non-invasive identification of patients with hypertrophic cardiomyopathy (HCM) [1, 2]. Subsequently, the utilization of two-dimensional echocardiography and other ultrasound modalities in large numbers of patients with HCM over many years have stimulated continued definition of the diverse morphologic expression of the disease, changes in left ventricular morphology which appear to be part of its natural history, and the clinical relevance of left ventricular hypertrophy within the broad spectrum of patients [3–18]. As a result, it has become apparent that the morphology of HCM may not be identical or even similar in different phases of life. With these considerations in mind, the present review is focused on the patterns of left ventricular hypertrophy and the relationship between age and left ventricular anatomy in patients with HCM.

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References

  1. Abbasi AS, MacAlpin RN, Eber LM, Pearce ML (1972) Echocardiographic diagnosis of idiopathic hypertrophic cardiomyopathy without outflow obstruction. Circulation 46: 897–904

    PubMed  CAS  Google Scholar 

  2. Henry WL, Clark CE, Epstein SE (1973) Asymmetric septal hypertrophy (ASH): Echocardiographic identification of the pathognomonic anatomic abnormality of IHSS. Circulation 47: 225–233

    PubMed  CAS  Google Scholar 

  3. Maron BJ, Epstein SE (1979) Hypertrophic cardiomyopathy: A discussion of nomenclature. Am J Cardiol 43: 1242–1244

    Article  PubMed  CAS  Google Scholar 

  4. Maron BJ, Gottdiener JS, Epstein SE (1981) Patterns and significance of distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy. A wide-angle, two-dimensional echocardiographic study of 125 patients. Am J Cardiol 48: 418–428

    Article  PubMed  CAS  Google Scholar 

  5. Wigle ED, Sasson Z, Henderson MA, et al (1985) Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review. Prog Cardiovasc Dis 28: 1–83

    Article  CAS  Google Scholar 

  6. Shapiro LM, McKenna WJ (1983) Distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy: a two-dimensional echocardiographic study. J Am Coll Cardiol 2: 437–444

    Article  PubMed  CAS  Google Scholar 

  7. Maron BJ, Gottdiener JS, Bonow RO, Epstein SE (1981) Hypertrophic cardiomyopathy with unusual locations of left ventricular hypertrophy undetectable by M-mode echocardiography: identification by wide-anlge, two-dimensional echocardiography. Circulation 63: 409–418

    Article  PubMed  CAS  Google Scholar 

  8. Louie EK, Maron BJ (1986) Hypertrophic cardiomyopathy with extreme increase in left ventricular wall thickness: clinical significance functional and morphologic features. J Am Coll Cardiol 8: 57–65

    Article  PubMed  CAS  Google Scholar 

  9. Keren G, Belhassen B, Sherez J, et al (1985) Apical hypertrophic cardiomyopathy: evaluation by noninvasive and invasive techniques in 23 patients. Circulation 71: 45–56

    Article  PubMed  CAS  Google Scholar 

  10. Maron BJ, Bonow RO, Cannon RO, Leon MB, Epstein SE (1987) Hypertrophic cardiomyopathy: interrelation of clinical manifestations, pathophysiology, and therapy. N Engl J Med 361:780–789, 844–852

    Article  Google Scholar 

  11. Ciro E, Nichols PF, Maron BJ (1983) Heterogeneous morphologic expression of genetically transmitted hypertrophic cardiomyopathy: two-dimensional echocardiographic analysis. Circulation 67: 1227–1233

    Article  PubMed  CAS  Google Scholar 

  12. Spirito P, Maron BJ, Bonow RO, Epstein SE (1986) Severe functional limitation in patients with hypertrophic cardiomyopathy and only mild localized left ventricular hypertrophy. Am J Coll Cardiol 8: 537–544

    Article  CAS  Google Scholar 

  13. Spirito P, Maron BJ, Bonow RO, Epstein SE (1987) Occurrence and significance of progressive left ventricular wall thinning and relative cavity dilatation in patients with hypertrophic cardiomyopathy. Am J Cardiol 60: 123–129

    Article  PubMed  CAS  Google Scholar 

  14. Koga Y, Itaya K, Toshima H (1984) Prognosis in hypertrophic cardiomyopathy. Am Heart J 108: 351–359

    Article  PubMed  CAS  Google Scholar 

  15. Louie EK, Maron BJ (1987) Apical hypertrophic cardiomyopathy: clinical and two- dimensional echocardiographic assessment. Ann Intern Med 106: 663–670

    PubMed  CAS  Google Scholar 

  16. Maron BJ, Nichols PF, Pickle LW, Wesley YE, Mulvihill JJ (1984) Patterns of inheritance in hypertrophic cardiomyopathy: assessment by M-mode and two-dimensional echocardiography. Am J Cardiol 53: 1087–1094

    Article  PubMed  CAS  Google Scholar 

  17. Maron BJ, Spirito P, Wesley Y, Arce J (1986) Development and progression of left ventricular hypertrophy in children with hypertrophic cardiomyopathy. N Engl J Med 315: 610–614

    Article  PubMed  CAS  Google Scholar 

  18. Lewis JF, Maron BJ (1989) Elderly patients with hypertrophic cardiomyopathy: a subset with distinctive left ventricular morphology and progressive clinical course late in life. J Am Coll Cardiol 13: 36–45

    Article  PubMed  CAS  Google Scholar 

  19. Maron BJ, Epstein SE (1980) Hypertrophic cardiomyopathy. Recent observations regarding the specificity of three hallmarks of the disease: asymmetric septal hypertrophy, septal disorganization and systolic anterior motion of the anterior mitral leaflet. Am J Cardiol 45: 141–154

    Article  PubMed  CAS  Google Scholar 

  20. Lewis JF, Maron BJ (1989) Diversity of patterns of left ventricular wall thickening in patients with systemic hypertension and marked hypertrophy. Am J Cardiol (in press)

    Google Scholar 

  21. Maron BJ (1986) Structural features of the athlete’s heart as defined by echocardiography. J Am Coll Cardiol 7: 190–203

    Article  PubMed  CAS  Google Scholar 

  22. Sakamoto T, Tei C, Murayama M, Ichiyasu H, Hada Y (1976) Giant T wave inversion as a manifestation of asymmetrical apical hypertrophy (AAH) of the left ventricle: echocardiographic and ultrasonocardiotomographic study. Jpn Heart J 17: 611–629

    Article  PubMed  CAS  Google Scholar 

  23. Yamaguchi H, Ishimura T, Nishiyma S, et al (1979) Hypertrophic nonobstructive cardiomyopathy with giant negative T waves (apical hypertrophy): ventriculographic and echocardiographic features in 30 patients. Am J Cardiol 44: 401–412

    Article  PubMed  CAS  Google Scholar 

  24. Maron BJ, Bonow RO, Seshagiri TNR, Roberts WC, Epstein SE (1981) Hypertrophic cardiomyopathy with ventricular septal hypertrophy localized to the apical region of the left ventricle (apical hypertrophic cardiomyopathy). Am J Cardiol 49: 1838–1848

    Article  Google Scholar 

  25. Spirito P, Maron BJ (1989) Relation between extent of left ventricular hypertrophy and occurrence of sudden cardiac death in hypertrophic cardiomyopathy. J Am Coll Cardiol (in press)

    Google Scholar 

  26. Spirito P, Watson RM, Maron BJ (1987) Relation betwen extent of left ventricular hypertrophy and occurrence of ventricular tachycardia in hypertrophic cardiomyopathy. Am J Cardiol 60: 1137–1142

    Article  PubMed  CAS  Google Scholar 

  27. Sanderson JE, Gibson DG, Brown DJ, et al (1978) Left ventricular filling in hypertrophic cardiomyopathy: an angiographic study. Br Heart J 39: 661–670

    Article  Google Scholar 

  28. Maron BJ, Spirito P, Green KJ, Wesley YE, Bonow RO, Arce J (1987) Noninvasive assessment of left ventricular diastolic function by pulsed Doppler echocardiography in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 10: 743–747

    Article  Google Scholar 

  29. Spirito P, Maron BJ, Chiarella F, et al (1985) Diastolic abnormalities in patients with hypertrophic cardiomyopathy: relation to magnitude of left ventricular hypertrophy. Circulation 72: 310–316

    Article  PubMed  CAS  Google Scholar 

  30. Spirito P, Maron BJ (1989) Relation between extent of left ventricular hypertrophy and diastolic abnormalities in patients with hypertrophic cardiomyopathy (submitted)

    Google Scholar 

  31. Spirito P, Maron BJ (1983) Significance of left ventricular outflow tract cross-sectional area in hypertrophic cardiomyopathy: a two-dimensional echocardiographic assessment. Circulation 67: 1100–1108

    Article  PubMed  CAS  Google Scholar 

  32. Maron BJ, Edwards JE, Henry WL, Clark CE, Bingle GJ, Epstein SE (1974) Asymmetric septal hypertrophy ( ASH) in infancy. Circulation 50: 809–820

    PubMed  CAS  Google Scholar 

  33. Maron BJ, Tajik AJ, Ruttenberg HD, Graham TP, Atwood GF, Victorica BE, Lie JT, Roberts WC (1982) Hypertrophic cardiomyopathy in infants: clinical features and natural history. Circulation 65: 7–17

    Article  PubMed  CAS  Google Scholar 

  34. Maron BJ, Wolfson JK, Epstein SE, Roberts WC (1986) Intramural (“small vessel”) coronary artery disease in hypertrophic cardiomyopathy. J Am Coll Cardiol 8: 545–557

    Article  PubMed  CAS  Google Scholar 

  35. Fiddler GI, Tajik AJ, Weidman WH, McGoon DC, Ritter DG, Giuliani ER (1978) Idiopathic hypertrophic subaortic stenosis in the young. Am J Cardiol 42: 793–799

    Article  PubMed  CAS  Google Scholar 

  36. McKena WJ, Franklin RCG, Nihoyannopoulos P, Robinson KC, Deanfield JE (1988) Arrhythmia and prognosis in infants, children and adolescents with hypertrophic cardiomyopathy. J Am Coll Cardiol 11: 147–153

    Article  Google Scholar 

  37. Panza JA, Maron BJ (1989) Relation of electrocardiographic abnormalities to evolving left ventricular hypertrophy in hypertrophic cardiomyopathy. Am J Cardiol 63: 1258–1265

    Article  PubMed  CAS  Google Scholar 

  38. Spirito P, Maron BJ (1987) Absence of progression of left ventricular hypertrophy in adult patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 9: 1013–1017

    Article  PubMed  CAS  Google Scholar 

  39. Maron BJ, Epstein SE, Roberts WC (1979) Hypertrophic cardiomyopathy and transmural myocardial infarction without significant atherosclerosis of the extramural coronary arteries. Am J Cardiol 43: 1086–1102

    Article  PubMed  CAS  Google Scholar 

  40. Spirito P, Maron BJ (1989) Relation between extent of left ventricular hypertrophy and age in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 13: 820–823

    Article  PubMed  CAS  Google Scholar 

  41. Ten Cate FJ, Hugenholtz PG, van Dorp WJ, Roelandt J (1979) Prevalence of diagnostic abnormalities in patients with genetically transmitted asymmetric septal hypertrophy. Am J Cardiol 43: 731–737

    Article  PubMed  Google Scholar 

  42. Greaves SC, Roche AHG, Neutze JM, Whitlock RML (1987) Inheritance of hyper-trophic cardiomyopathy: a cross-sectional and M-mode echocardiographic study of 50 families. Br Heart J 58: 259–266

    Article  PubMed  CAS  Google Scholar 

  43. Ciro E, Maron BJ, Roberts WC (1982) Coexistence of asymmetric and symmetric left ventricular hypertrophy in a family with hypertrophic cardiomyopathy. Am Heart J 104: 643–646

    Article  PubMed  CAS  Google Scholar 

  44. Maron BJ, Roberts WC, McAllister HA, Rosing DR, Epstein SE (1980) Sudden death in young athletes. Circulation 62: 218–229

    PubMed  CAS  Google Scholar 

  45. Maron BJ (1985) Asymmetry in hypertrophic cardiomyopathy: The septal to free wall thickness ratio revisited. Am J Cardiol 55: 835–838

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. B. J. Maron
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Editors and Affiliations

  1. Istituto Fisiologia Clinica CNR, Dipartimento di Cardiologia A. De Gasperis, Ospedale Niguarda, Ca’ Granda, Piazza Ospedale Maggiore 3, 20612, Milan, Italy

    G. Baroldi M.D.

  2. Dipartimento di Cardiologia, Ospedale Maggiore, Piazza Ospedale 1, 34129, Trieste, Italy

    F. Camerini M.D.

  3. 2 Pine Grove, Lake Road, SW19 7HE, Wimbledon, London, UK

    J. F. Goodwin M.D.

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© 1990 Springer-Verlag Berlin Heidelberg

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Maron, B.J. (1990). Evolution of Left Ventricular Hypertrophy in Patients with Hypertrophic Cardiomyopathy. In: Baroldi, G., Camerini, F., Goodwin, J.F. (eds) Advances in Cardiomyopathies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83760-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-83760-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83762-3

  • Online ISBN: 978-3-642-83760-9

  • eBook Packages: Springer Book Archive

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