Dichotomous Effects of Cyclophosphamide in Murine Coxsackievirus B3-Induced Myocarditis
Enteroviruses, especially of the Coxsackie group, seem to be major causative agents for myocarditis in humans. Murine Coxsackie B3-induced myocarditis resembles the human disease closely. The immune system plays an essential role in mediating the disease . As in humans, cellular and humoral immune reactions to the myocardium have been described. In BALB/c mice, Huber et al. demonstrated cytotoxic T lymphocytes to virally infected and uninfected cardiac myocytes . Antibodies to cardiac myosin of the IgG isotype and other epitopes have been demonstrated to be responsible especially for the chronic stage of Coxsackie B3-induced murine myocarditis . In humans, antibodies to myocardial cells can be found at a high incidence in the serum of patients with acute myocarditis and postmyocarditic heart muscle disease [9, 10]. Monoclonal antibodies cross-reacting between Coxsackie B3 epitopes and myocardium have recently been described .
KeywordsSuppressor Cell Virus Inoculation Cardiac Myosin Acute Myocarditis Coxsackie Virus
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