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Dichotomous Effects of Cyclophosphamide in Murine Coxsackievirus B3-Induced Myocarditis

  • M. Herzum
  • S. A. Huber
  • B. Maisch
Conference paper

Abstract

Enteroviruses, especially of the Coxsackie group, seem to be major causative agents for myocarditis in humans. Murine Coxsackie B3-induced myocarditis resembles the human disease closely. The immune system plays an essential role in mediating the disease [12]. As in humans, cellular and humoral immune reactions to the myocardium have been described. In BALB/c mice, Huber et al. demonstrated cytotoxic T lymphocytes to virally infected and uninfected cardiac myocytes [5]. Antibodies to cardiac myosin of the IgG isotype and other epitopes have been demonstrated to be responsible especially for the chronic stage of Coxsackie B3-induced murine myocarditis [1]. In humans, antibodies to myocardial cells can be found at a high incidence in the serum of patients with acute myocarditis and postmyocarditic heart muscle disease [9, 10]. Monoclonal antibodies cross-reacting between Coxsackie B3 epitopes and myocardium have recently been described [6].

Keywords

Suppressor Cell Virus Inoculation Cardiac Myosin Acute Myocarditis Coxsackie Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. Herzum
  • S. A. Huber
  • B. Maisch

There are no affiliations available

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