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Self-Nonself Discrimination by the Immune System

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Progress in Immunology

Abstract

The immune system recognizes antigen by sets of very diverse proteins which are anchored in the membrane of lymphocytes. Each lymphocyte has only one type of receptor which differs from that on other lymphocytes (Burnet 1959). The receptor genes are formed by random rearrangement of gene segments in somatic cells (Tonegawa et al 1976). The receptors on B lymphocytes are called antibodies which can be secreted by antigenically stimulated B lymphocytes. T lymphocytes express T cell receptors (TCR) which cannot be secreted and are encoded by a different set of genes (Hedrick et al 1984).

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© 1989 Springer-Verlag Berlin Heidelberg

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von Boehmer, H., Kishi, H., Scott, B., Borgulya, P., Teh, H.S., Kisielow, P. (1989). Self-Nonself Discrimination by the Immune System. In: Melchers, F., et al. Progress in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83755-5_40

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  • DOI: https://doi.org/10.1007/978-3-642-83755-5_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83757-9

  • Online ISBN: 978-3-642-83755-5

  • eBook Packages: Springer Book Archive

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