Participation of CD4 and CD8 Accessory Molecules in the Development and Selection of T Lymphocytes
The contributions of the CD4 and CD8 accessory molecules to T cell receptor (TCR) specificity and thymic selection are matters of considerable interest. The tight correlation between CD4 expression and class II recognition and CD8 expression and class I recognition suggest that the accessory molecules are involved in specific MHC class recognition (Reinherz et al. 1983; Swain 1983). Supporting this notion is the fact that class I-specific responses can be blocked by anti-CD8 and class II by anti-CD4 antibodies (Marrack et al. 1983; Dialynas et al. 1983a). Others have provided data which demonstrate direct binding between accessory molecules and MHC (Doyle and Strominger, 1987).
KeywordsClonal Deletion Accessory Molecule Thymic Selection IgG2a Isotype Syngeneic Bone Marrow
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