Abstract
The contributions of the CD4 and CD8 accessory molecules to T cell receptor (TCR) specificity and thymic selection are matters of considerable interest. The tight correlation between CD4 expression and class II recognition and CD8 expression and class I recognition suggest that the accessory molecules are involved in specific MHC class recognition (Reinherz et al. 1983; Swain 1983). Supporting this notion is the fact that class I-specific responses can be blocked by anti-CD8 and class II by anti-CD4 antibodies (Marrack et al. 1983; Dialynas et al. 1983a). Others have provided data which demonstrate direct binding between accessory molecules and MHC (Doyle and Strominger, 1987).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bruce J, Symington F, McKearn T, Sprent J (1981) J Immunol 127:2496
Dembic Z, Haas W, Zamoyska R, Parnes J, Steinmetz M, von Boehmer H (1987) Nature 326:510
Dialynas DP, Quan ZS, Wall KA, Pierres A, Quintans J, Loken MR, Pierres M, Fitch FW (1983a) J Immunol 131:2445
Dialynas DP, Wilde DB, Marrack P, Pierres A, Wall KA, Havran W, Otten G, Loken MR, Pierres M, Kappler J, Fitch FW (1983b) Immunol Rev 74:301
Doyle C, Strominger JL (1987) Nature 330:256
Emmrich F, Kanz L, Eichmann K (1987) Eur J Immunol 17:529
Fowlkes BJ, Schwartz RS, Pardoll DM (1988) Nature 334:620
Gabert J, Langlet C, Zamoyska R, Parnes JR, Schmitt-Verhulst AM, Malissen B (1987) Cell 50:545
Gay D, Maddon P, Sekaly R, Talle MA, Godfrey M, Long E, Goldstein G, Chess L, Axel R, Kappler J, Marrack P (1987) Nature 328:626
Kappler JW, Roehm N, Marrack P (1987) Cell 49:273
Kruisbeek AM, Mond JJ, Fowlkes BJ, Carmen JA, Bridges S, Longo DL (1985) J Exp Med 161:1029
Ledbetter JA, Herzenberg LA (1979) Immunol Rev 47:63
Ledbetter JA, June CH, Rabinovitch PS, Grossmann A, Tsu TT, Imboden JB (1988) Eur J Immunol 18:525
MacDonald HR, Hengartner H, Pedrazzini T (1988) Nature 335:174
Marrack P, Endres R, Shimonkevitz R, Zlotnik A, Dialynas D, Fitch F, Kappler J (1983) J Exp Med 158:1077
Marrack PC, Kushnir E, Born W, McDuffie M, Kappler JW (1988) J Immunol 140:2508
Marusic-Galesic S, Stephany D, Longo DL, Kruisbeek AM (1988) Nature 333:180
McCarthy SA, Kruisbeek AM, Uppenkamp IK, Sharrow SO, Singer A (1988) Nature 336:76
Pierres A, Naquet P, van Agthoven A, Bekkhoucha F, Denizot F, Mishal Z, Schmitt-Verhulst A, Pierres M (1984) J Immunol 132:2275
Qin S, Cobbold S, Benjamin R, Waldmann H (1989) J Exp Med 169:779
Ramsdell F, Fowlkes BJ (1989) J Immunol (in press)
Reinherz EL, Meuer SC, Schlossman SF (1983) Immunol Today 4:5
Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh DY (1988) Nature 335:271
Swain SL (1983) Immunol Rev 74:129
Teh HS, Kisielow P, Scott B, Kishi H, Uematsu Y, Bluthmann H, von Boehmer H (1988) Nature 335:229
Veillette A, Bookman MA, Horak EM, Bolen JB (1988) Cell 55:301
Veillette A, Bookman MA, Horak EM, Samelson LE, Bolen JB (1989) Nature 338:257
von Boehmer H (1986) Immunol Today 7:333
Zúñiga-Pflücker JC, McCarthy SA, Weston M, Longo DL, Singer A, Kruisbeek AM (1989) J Exp Med 169:2085
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Fowlkes, B.J., Pardoll, D., Lantz, T., Ramsdell, F. (1989). Participation of CD4 and CD8 Accessory Molecules in the Development and Selection of T Lymphocytes. In: Melchers, F., et al. Progress in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83755-5_38
Download citation
DOI: https://doi.org/10.1007/978-3-642-83755-5_38
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83757-9
Online ISBN: 978-3-642-83755-5
eBook Packages: Springer Book Archive