Abstract
Complement component C3 synthesis by two human lymphoid cell lines was investigated at the mRNA and protein levels. We report that the C3 gene is constitutively transcribed and that C3 protein is synthesized, secreted and proteolytically processed in cell lines of the lymphoid lineage. Because C3 fragments are implicated in lymphocyte growth control, we will also discuss the significance of C3 fragments as potential autocrine growth regulators.
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References
Barel M, Chariaut C, Frade R (1981) FEBS Lett 136:111–115
Bohnsack JF, Cooper NR (1988) J Immunol 141:2569–2576
Cooper NR, Moore MD, Nemerow GR (1988) Ann Rev Immunol 6:85–113
Domdey H, Wiebauer K, Kazmaier M, Muller V, Odink K, Fey G (1982) Proc Natl Acad Sei USA 79:7619–7623
DeBruijn MHL, Fey GH (1985) Proc Natl Acad Sei USA 82:708–712
Fey G, Domdey H, Wiebauer K, Whitehead AS, Odink K (1985) In: Müller-Eberhard HJ, Miescher PA (eds) Complement. Springer-Verlag, Berlin, pp 9–37
Goodrum KJ (1987) Leukocyte Biol 41:295–301
Hatzfeld A, Fischer E, Levesque JP, Perrin R, Hatzfeld J, Kazatchkine MD (1988) J Immunol 140:170–175
Iida K, Nadler L, Nussenzweig V (1983) J Exp Med 158:1021–1032
Klaus GGB, Humphrey JH (1986) Immunol Today 7:163–166
Lambris JD, Ganu U, Hirani S, Müller-Eberhard H (1985) Proc Natl Acad Sei USA 82:4235–4239
Lernhardt W, Raschke WC, Melchers F (1986) Curr Top Microbiol Immunol 132:98–104
Lernhardt W, Karasuyama H, Rolink A, Melchers F (1987) Immunol Rev 99:241–262
Melchers F, Erdei A, Schulz T, Dierich M (1985) Nature 317:264–267
Minta JO, Isenman DE (1987) Molec Immunol 24:1105–1111
Nichols WK (1984) Complement 1:108–115
Senger DR, Hynes RO (1978) Cell 15:375–387
Thomas ML, Tack BF (1983) Biochemistry 22:942–947
Weigle WO, Goodman MG, Morgan EL, Hugli TE (1985) In: Müller-Eberhard HJ, Miescher PA (eds) Complement. Springer-Verlag, Berlin, pp 323–344
Whitehead AS, Sim RB, Bodmer WF (1981) Eur J Immunol 11:140–146
Zimmer B, Härtung H-P, Scharfenberger G, Bitter-Suermann D, Hadding U (1982) Eur J Immunol 12:426–430
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© 1989 Springer-Verlag Berlin Heidelberg
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Salas, F. et al. (1989). Production of Complement Component C3 by Lymphoid Cell Lines: Possible Function of C3 Fragments as Autocrine Growth Regulators. In: Melchers, F., et al. Progress in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83755-5_27
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DOI: https://doi.org/10.1007/978-3-642-83755-5_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83757-9
Online ISBN: 978-3-642-83755-5
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