Abstract
Mammmals have evolved a number of different ways of recognising the arrival in their bodies of a foreign invader. At least 3 of these appear to be antigen specific, by virtue of the fact that the foreign invaders are recognised by receptors which vary in sequence from one cell to another.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alt F, Rosenberg N, Lewis S, Thomas E, Baltimore B (1981) Organization and reorganization of immunoglobulin genes in A-Multi-tansformed cells: Rearrangement of heavy but not light chain genes. Cell 27:381–390
Behlke M, Chou H, Huppi K, Loh D (1986) Murine T cell receptor mutants with deletions of β-chain variable region genes. Proc Natl. Acad. Sci. USA 83:767–771
Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329:506–512
Born W, Yague J, Palmer E, Kappler J, Marrack P. (1985) Rearrangement of T cell receptor β chain genes during T cell development. Proc. Natl. Acad. Sci. (USA) 82:2925–2929
Chien Y, Iwashima M, Kaplan KB, Elliott JF, Davis MM (1987) A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. Nature 327:677–682
Elliot JF, Rock EP, Patten PA, Davis MM Chien Y (1988) The adult T cell receptor δ chain is diverse and distinct from that of fetal thymocytes. Nature 331:627–631
Fink P, Matis L, Mlligott D, Bookman M, Hedrick S (1986) Correlations between T cell specificity and structure of the antigen receptor. Nature 321:219–226
Finkel TH, Cambier JC, Kubo RT, Born WK, Marrack P, Kappler JW (1989) The thymus has two functionally distinct populations of immature αβ+ T cells: one population is deleted by ligation of αβTCR. Cell in press
Haqqi TM, Banergee S, Anderson GD, David CS (1989) RIIIS/J (H-2r). An inbred mouse strain with a massive deletion of T cell receptor V/3 genes. J. Exp. Med. 169:1903–1910
Havran WL, Allison JP (1988) Developementally ordered appearence of thymocytes expressing different T-cell antigen receptors. Nature 335:443–445
Honjo T (1983) Immunoglobulin genes. Ann. Rev. Immunol. 1:499–528
Janeway Jr CA, Yagi J, Conrad P, Katz M, Vroegop S, Buxser S (1989) T cell responses to Mis and to bacterial proteins that mimic its behavior. Immunol. Reviews 107:61–88
Janis EM, Kaufmann SHE, Schwartz RH, Pardoll DM (1989) Activation of γδ T cells in the primary immune response to Mycobacterium tuberculosis. Science 244:713–716
Kappler J, Kotzin B, Herron L, Gelfand E, Bigler R, Boylston A, Carrel S, Posnett D, Choi Y, Marrack P (1989) Vβ-specific stimulation of human T cells by staphylococcal toxins. Science 244:811–813
Kappler JW, Staerz U, White J, Marrack PC (1988) Selftolerance eliminates T cells specific for Mis-modified products of the major histocompatibility complex. Nature 332:35–40
Kappler J, Roehm N, Marrack P (1987) T cell tolerance by clonal elimination in the thymus. Cell 49:273–280
Kotzin B, Barr V, Palmer E (1985) A large deletion within the T-cell receptor beta-chain gene complex in New Zealand white mice. Science 229:167–171
Kronenberg M, Siu G, Hood L, Shastri N (1986) The molecular genetics of the T cell antigen receptor and T cell antigen recognition. Ann. Rev. Immunol. 4:529–592
MacDonald HR, Schneider R, Lees RK, Howe RC, Acha-Orbea H, Festenstein H, Zinkernagel RM Hengartner H (1988) T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature 332:40–45
Matis LA, Cron R, Bluestone JA (1987) Major histocompatibility-linked specificity of γδ receptorbearing T lymphocytes. Nature 330:262–264
Matzinger P, Bevan M (1977) Hypothesis: Why do so many lymphocytes respond to major histocompatibility antigens? Cell. Immunol. 29:1–5
Mercep M, Bonifacino JS, Garcia-Morales P, Samelson LE, Klausner RD, Ashwell JD (1988) T cell CD3-|n heterodimer expression and coupling to phosphoinositide hydrolysis. Science 242:571–574
O’Brien RL, Happ MP, Dallas A, Palmer E, Kubo R, Born WK Stimulation of a major subset of lymphocytes expressing T cell receptor γδ by an antigen derived from Mycobacterium tuberculosis. Cell 57:667–674
Tonegawa S (1983) Somatic generation of antibody diversity. Nature 303:575–581
White J, Herman A, Pullen AM, Kubo R, Kappler J, Marrack P (1989) The Vβ-specific superantigen Staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56:27–35
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Marrack, P. et al. (1989). T Cell Receptors. In: Melchers, F., et al. Progress in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83755-5_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-83755-5_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83757-9
Online ISBN: 978-3-642-83755-5
eBook Packages: Springer Book Archive