Pharmaceutical Technology in Selective Decontamination

  • D. Crome
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 7)


It has been clearly demonstrated that a number of conditions, such as severe trauma [1], advanced age [2] and medical interventions (e.g. chemotherapy and surgery) [3, 4] are associated with acquisition and subsequent colonization and infection by gram-negative bacilli and yeasts.


Propylene Glycol Pharmaceutical Technology Lower Gastrointestinal Tract Multiple Trauma Patient Selective Decontamination 
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  1. 1.
    Stoutenbeek CP, van Saene HKF, Miranda DR, Zandstra DF (1984) The effect of selective decontamination of the digestive tract on colonization and infection rate in multiple trauma patients. Inten Care Med 10: 185–192CrossRefGoogle Scholar
  2. 2.
    Nicolle LE, McLead J, McIntyre M, MacDonnell JA (1986) Significance of pharyngeal colonization with aerobic Gram negative bacilli in elderly institutionalised men. Age Ageing 5: 47–52.CrossRefGoogle Scholar
  3. 3.
    Samaranayke LP, Calman KC, Ferguson MM et al (1984) The oral carriage of yeasts in patients on cytotoxic therapy. 13: 390–393.Google Scholar
  4. 4.
    Johanson WG, Pierce AK, Sanford JP (1969) Changing pharyngeal bacterial flora of hospitalised patients. New Engl J Med 281: 1137–1140.PubMedCrossRefGoogle Scholar
  5. 5.
    van Saene HKF, Stoutenbeek CP (1987) Selective decontamination. J Antimicrob Chemother 20: 462–465PubMedCrossRefGoogle Scholar
  6. 6.
    Stoutenbeek CP, van Saene HKF, Miranda DR, Zandstra DF (1987) The effect of oropharyngeal decontamination using topical non-absorbable antibiotics on the incidence of nosocomial respiratory tract infections in multiple trauma patients. J Trauma 27: 357–361PubMedCrossRefGoogle Scholar
  7. 7.
    van Saene JJM, van Saene HKF (1989) Antimicrobial lozenges used for selective elimination of oropharyngeal flora in patients at high risk. J Clin Hosp (in press)Google Scholar

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© Springer-Verlag Berlin Heidelberg 1989

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  • D. Crome

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