Abstract
Homozygous ichthyotic (ic/ic) animals are easily distinguished from heterozygous littermates by their smaller size, short, sparse coat, scaliness of “bare” skin (paws, ears, tail), short vibrissae, and accumulation of scale superimposed upon segmental rings of the tail (Fig. 286). Expression of the ic/ic phenotype varies considerably, even among affected littermates (Carter and Phillips 1950; Jensen and Esterly 1977). Severely affected animals have thick, confluent, rigid, cutaneous plates that crack and are gradually shed. The hair is usually diminished in quantity, and animals can be nearly bald. Mildly affected animals have small scales surrounding the orifices of hair follicles confined to the feet, tail, and ears (Jensen and Esterly 1971) (Fig. 287).
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© 1989 Springer-Verlag Berlin Heidelberg
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Holbrook, K.A. (1989). Ichthyosis, Inherited, Skin, Mouse (ic/ic). In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Integument and Mammary Glands. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83749-4_37
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DOI: https://doi.org/10.1007/978-3-642-83749-4_37
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