Abstract
Papilloma of the skin appears as single or multiple small verrucous papules at the site of application of a carcinogen or irradiation. These papules are usually a few millimeters in diameter and rarely exceed 1 cm in diameter. The surface of the tumors may be covered by a keratin mass, and as the tumors grow bigger, their surface can become ulcerated or crusted. Papillomas never adhere to the deeper layer. Small papillomas of less than 3 mm in diameter often undergo spontaneous regression.
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References
Albert RE, Phillips ME, Bennett P, Burns F, Heimbach R (1969) The morphology and growth characteristics of radiation-induced epithelial skin tumors in the rat. Cancer Res 29: 658–668
Arffmann E, Hjoorne N (1979) Influence of surface lipids on skin carcinogenesis in rats. Acta Pathol Microbiol Immunol Scand [A] 87: 143–149
Burek JD, Hollander CF (1977) Incidence patterns of spontaneous tumors in BN/Bi rats. JNCI 58: 99–105
Cherry CP, Glucksmann A (1971) The influence of carcinogenic dosage and of sex on the induction of epitheliomas and sarcomas in the dorsal skin of rats. Br J Cancer 25: 544–564
Crain RC (1958) Spontaneous tumors in the Rochester strain of the Wistar rat. Am J Pathol 34: 311–335
Fare G (1966) Rat skin carcinogenesis by topical applica- tions of some azo dyes. Cancer Res 26: 2406–2408
Fukushima S, Ito N (1985) Papilloma, forestomach, rat. In: Jones TC, Mohr U, Hunt RD (eds) ILSI monograph on pathology of laboratory animals, digestive system. Springer, Berlin Heidelberg New York, pp 289–292
Ghadially FN (1960) Carcinogenesis in the skin of the hedgehog. Br J Cancer 14: 212–215
Ghadially FN (1961) The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals. Cancer 14: 801–816
Glucksmann A, Cherry CI (1971) The effect of variation in carcinogenic dosage on the induction of tumours in the dorsal and vulval skin of female rats. Br J Cancer 25: 735–745
Goodman DG, Ward JM, Squire RA, Chu KC, Lin-hart MS (1979) Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol 48: 237–248
Haseman JK, Huff JE, Rao GN, Arnold JE, Boorman GA, McConnell EE (1985) Neoplasms observed in untreated and corn oil gavage control groups of F344/N rats and (C57BL/6N x C3H/HeN)F1(B6 C3F1) mice. JNCI 75: 975–984
Hirose M, Maekawa A, Kamiya S, Odashima S (1979) Carcinogenic effect of N-ethyl-and N-amyl-N-nitrosourethanes on female Donryu rats. Gann 70: 653–662
Howell JS (1962) Skin tumors in the rat produced by 9,10-dimethyl-1,2-benzanthracene and methylcholanthrene. Br J Cancer 16: 101–109
Lennox B (1955) The production of a variety of skin tumours in rats with 2-anthramine and a comparison with the effects in mice. Br J Cancer 9: 631–639
MacKenzie WF, Garner FM (1973) Comparison of neoplasms in six sources of rats. JNCI 50: 1243–1257
Maekawa A, Odashima S (1975) Spontaneous tumors in ACI/N rats. JNCI 55: 1437–1445
Maekawa A, Kurokawa Y, Takahashi M, Kokubo T, Ogiu T, Onodera H, Tanigawa H, Ohno Y, Furukawa F, Hayashi Y (1983a) Spontaneous tumors in F344/DuCrj rats. Gann 74: 365–372
Maekawa A, Onodera H, Tanigawa H, Furuta K, Koda-ma Y, Horiuchi S, Hayashi Y (1983b) Neoplastic and non-neoplastic lesions in aging Slc: Wistar rats. J Toxicol Sci 8: 279–290
Mehregan AH (1986) Pinkus’ guide to dermatohistopathology 4th edn. Appleton-Century-Crofts, Norwalk, pp 443–460
Meranze DR, Gruenstein M, Shimkin MB (1969) Effect of age and sex on the development of neoplasms in Wistar rats receiving a single intragastric instillation of 7,12-dimethylbenz(a)anthracene. Int J Cancer 4: 480–486
Palotay JL, Adachi K, Dobson RL, Pinto JS (1976) Carcinogen induced cutaneous neoplasms in nonhuman primates. JNCI 57: 1269–1274
Prejean JD, Peckham JC, Casey AE, Griswold DP, Weis-burger EK, Weisburger JH (1973) Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res 33: 2768–2773
Rasmussen KS, Glenthoj A, Arffmann E (1983) Skin carcinogenesis in rats by 3-methylcholanthrene and 7,12-dimethylbenz(a)anthracene. Influence of dose and frequency on tumour response and its histological type. Acta Pathol Microbiol Immunol Scand [A] 91: 445–455
Rigdon RH (1952) Tumors produced by methylcholanthrene in the duck. Papilloma, squamous-cell carcinoma, and hemangioma. Arch Pathol Lab Med 54: 368–377
Schweizer J, Loehrke H, Hesse B, Goerttler K (1982) 7,12-dimethylbenz(a)anthracene/12–0-tetradecanoylphorbol-13- acetate-mediated skin tumor initiation and promotion in male Sprague-Dawley rats. Carcinogenesis 3: 785–789
Stenbäck F (1980) Skin carcinogenesis as a model system: observations on species, strain and tissue sensitivity to 7,12-dimethylbenz(a)anthracene with or without promotion from croton oil. Acta Pharmacol Toxicol (Copenh) 46: 89–97
Zabezhinski MA, Pliss GB, Okulov VB, Petrov AS (1985) Skin tumours induced by local and systemic action of N-nitroso-compounds in rats. Arch Geschwulstforsch 55: 117–122
Zackheim HS (1964a) Evolution of squamous cell carcinoma in the rat. Arch Pathol Lab Med 77: 434–444
Zackheim HS (1964b) Comparative cutaneous carcinogenesis in the rat. Differential response to the application of anthramine, methylcholanthrene, and dimethylbenzanthracene. Oncology 17: 236–246
Zackheim HS (1973) Tumours of the skin. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol 1.
Zackheim HS, Simpson WL, Langs L (1959) Basal cell epitheliomas and other skin tumors produced in rats and mice by anthramine and methylcholanthrene. J Invest Dermatol 33: 385–402
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Hirose, M. (1989). Squamous Cell Papilloma, Skin, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Integument and Mammary Glands. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83749-4_2
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DOI: https://doi.org/10.1007/978-3-642-83749-4_2
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