Skip to main content

Squamous Cell Papilloma, Skin, Rat

  • Chapter
Integument and Mammary Glands

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

  • 190 Accesses

Abstract

Papilloma of the skin appears as single or multiple small verrucous papules at the site of application of a carcinogen or irradiation. These papules are usually a few millimeters in diameter and rarely exceed 1 cm in diameter. The surface of the tumors may be covered by a keratin mass, and as the tumors grow bigger, their surface can become ulcerated or crusted. Papillomas never adhere to the deeper layer. Small papillomas of less than 3 mm in diameter often undergo spontaneous regression.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albert RE, Phillips ME, Bennett P, Burns F, Heimbach R (1969) The morphology and growth characteristics of radiation-induced epithelial skin tumors in the rat. Cancer Res 29: 658–668

    PubMed  CAS  Google Scholar 

  • Arffmann E, Hjoorne N (1979) Influence of surface lipids on skin carcinogenesis in rats. Acta Pathol Microbiol Immunol Scand [A] 87: 143–149

    Google Scholar 

  • Burek JD, Hollander CF (1977) Incidence patterns of spontaneous tumors in BN/Bi rats. JNCI 58: 99–105

    PubMed  CAS  Google Scholar 

  • Cherry CP, Glucksmann A (1971) The influence of carcinogenic dosage and of sex on the induction of epitheliomas and sarcomas in the dorsal skin of rats. Br J Cancer 25: 544–564

    Article  PubMed  CAS  Google Scholar 

  • Crain RC (1958) Spontaneous tumors in the Rochester strain of the Wistar rat. Am J Pathol 34: 311–335

    PubMed  CAS  Google Scholar 

  • Fare G (1966) Rat skin carcinogenesis by topical applica- tions of some azo dyes. Cancer Res 26: 2406–2408

    PubMed  CAS  Google Scholar 

  • Fukushima S, Ito N (1985) Papilloma, forestomach, rat. In: Jones TC, Mohr U, Hunt RD (eds) ILSI monograph on pathology of laboratory animals, digestive system. Springer, Berlin Heidelberg New York, pp 289–292

    Google Scholar 

  • Ghadially FN (1960) Carcinogenesis in the skin of the hedgehog. Br J Cancer 14: 212–215

    Article  PubMed  CAS  Google Scholar 

  • Ghadially FN (1961) The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals. Cancer 14: 801–816

    Article  PubMed  CAS  Google Scholar 

  • Glucksmann A, Cherry CI (1971) The effect of variation in carcinogenic dosage on the induction of tumours in the dorsal and vulval skin of female rats. Br J Cancer 25: 735–745

    Article  PubMed  CAS  Google Scholar 

  • Goodman DG, Ward JM, Squire RA, Chu KC, Lin-hart MS (1979) Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol 48: 237–248

    Article  PubMed  CAS  Google Scholar 

  • Haseman JK, Huff JE, Rao GN, Arnold JE, Boorman GA, McConnell EE (1985) Neoplasms observed in untreated and corn oil gavage control groups of F344/N rats and (C57BL/6N x C3H/HeN)F1(B6 C3F1) mice. JNCI 75: 975–984

    PubMed  CAS  Google Scholar 

  • Hirose M, Maekawa A, Kamiya S, Odashima S (1979) Carcinogenic effect of N-ethyl-and N-amyl-N-nitrosourethanes on female Donryu rats. Gann 70: 653–662

    PubMed  CAS  Google Scholar 

  • Howell JS (1962) Skin tumors in the rat produced by 9,10-dimethyl-1,2-benzanthracene and methylcholanthrene. Br J Cancer 16: 101–109

    Article  PubMed  CAS  Google Scholar 

  • Lennox B (1955) The production of a variety of skin tumours in rats with 2-anthramine and a comparison with the effects in mice. Br J Cancer 9: 631–639

    Article  PubMed  CAS  Google Scholar 

  • MacKenzie WF, Garner FM (1973) Comparison of neoplasms in six sources of rats. JNCI 50: 1243–1257

    CAS  Google Scholar 

  • Maekawa A, Odashima S (1975) Spontaneous tumors in ACI/N rats. JNCI 55: 1437–1445

    PubMed  CAS  Google Scholar 

  • Maekawa A, Kurokawa Y, Takahashi M, Kokubo T, Ogiu T, Onodera H, Tanigawa H, Ohno Y, Furukawa F, Hayashi Y (1983a) Spontaneous tumors in F344/DuCrj rats. Gann 74: 365–372

    PubMed  CAS  Google Scholar 

  • Maekawa A, Onodera H, Tanigawa H, Furuta K, Koda-ma Y, Horiuchi S, Hayashi Y (1983b) Neoplastic and non-neoplastic lesions in aging Slc: Wistar rats. J Toxicol Sci 8: 279–290

    Article  PubMed  CAS  Google Scholar 

  • Mehregan AH (1986) Pinkus’ guide to dermatohistopathology 4th edn. Appleton-Century-Crofts, Norwalk, pp 443–460

    Google Scholar 

  • Meranze DR, Gruenstein M, Shimkin MB (1969) Effect of age and sex on the development of neoplasms in Wistar rats receiving a single intragastric instillation of 7,12-dimethylbenz(a)anthracene. Int J Cancer 4: 480–486

    Article  PubMed  CAS  Google Scholar 

  • Palotay JL, Adachi K, Dobson RL, Pinto JS (1976) Carcinogen induced cutaneous neoplasms in nonhuman primates. JNCI 57: 1269–1274

    PubMed  CAS  Google Scholar 

  • Prejean JD, Peckham JC, Casey AE, Griswold DP, Weis-burger EK, Weisburger JH (1973) Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res 33: 2768–2773

    PubMed  CAS  Google Scholar 

  • Rasmussen KS, Glenthoj A, Arffmann E (1983) Skin carcinogenesis in rats by 3-methylcholanthrene and 7,12-dimethylbenz(a)anthracene. Influence of dose and frequency on tumour response and its histological type. Acta Pathol Microbiol Immunol Scand [A] 91: 445–455

    CAS  Google Scholar 

  • Rigdon RH (1952) Tumors produced by methylcholanthrene in the duck. Papilloma, squamous-cell carcinoma, and hemangioma. Arch Pathol Lab Med 54: 368–377

    CAS  Google Scholar 

  • Schweizer J, Loehrke H, Hesse B, Goerttler K (1982) 7,12-dimethylbenz(a)anthracene/12–0-tetradecanoylphorbol-13- acetate-mediated skin tumor initiation and promotion in male Sprague-Dawley rats. Carcinogenesis 3: 785–789

    Google Scholar 

  • Stenbäck F (1980) Skin carcinogenesis as a model system: observations on species, strain and tissue sensitivity to 7,12-dimethylbenz(a)anthracene with or without promotion from croton oil. Acta Pharmacol Toxicol (Copenh) 46: 89–97

    Article  Google Scholar 

  • Zabezhinski MA, Pliss GB, Okulov VB, Petrov AS (1985) Skin tumours induced by local and systemic action of N-nitroso-compounds in rats. Arch Geschwulstforsch 55: 117–122

    PubMed  CAS  Google Scholar 

  • Zackheim HS (1964a) Evolution of squamous cell carcinoma in the rat. Arch Pathol Lab Med 77: 434–444

    CAS  Google Scholar 

  • Zackheim HS (1964b) Comparative cutaneous carcinogenesis in the rat. Differential response to the application of anthramine, methylcholanthrene, and dimethylbenzanthracene. Oncology 17: 236–246

    Article  PubMed  CAS  Google Scholar 

  • Zackheim HS (1973) Tumours of the skin. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol 1.

    Google Scholar 

  • Zackheim HS, Simpson WL, Langs L (1959) Basal cell epitheliomas and other skin tumors produced in rats and mice by anthramine and methylcholanthrene. J Invest Dermatol 33: 385–402

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hirose, M. (1989). Squamous Cell Papilloma, Skin, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Integument and Mammary Glands. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83749-4_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83749-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83751-7

  • Online ISBN: 978-3-642-83749-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics