Abstract
In the course of a virus infection of the liver, hepatocellular damage may result either directly from the replication of virus particles in the parenchymal cells, as is the case in mouse hepatitis, (Bang and Warwick, 1959) or indirectly from the effect of immunological factors in response to an antigenic virus-induced transformation of the hepatocyte membrane. The toxic degenerative hepatitis produced by Frog Virus 3 in mice or rats (Kirn, 1971; Kirn et al., 1972) constitutes a new model of hepatocellular injury in which the damage to the parenchymal cells is secondary to sinusoidal cell necrosis produced by FV 3 particles or FV 3 proteins.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aubertin AM, Anton M, Bingen A, et al. (1977) Solubilised viral proteins produce fatal hepatitis in mice. Nature 265: 456–457.
Bang FB, Warwick A (1959) Macrophages and mouse hepatitis. Virology 9: 715–717.
Bingen A, Bouteille M, Kirn A (1982) Localization by autoradiography of viral proteins in the parenchymal cells of the liver during Frog Virus 3 induced hepatitis of mice. J Submicrosc Cytol 14: 55–62.
Elharrar M, Bingen A, Gendrault JL, et al. (1975) Pathogenesis of Frog Virus 3 induced hepatitis in mice. In: Keppler D, ed. Pathogenesis and Mechanisms of liver cell necrosis. Lancaster: Medical and Technical Publishers, 75–86.
Elharrar M, Kirn A (1974) Inhibition of DNA synthesis by isolated liver nuclei from Frog Virus 3 infected mice. Biochem Biophys Res Commun 57: 801–807.
Elharrar M, Kirn A (1977) Effect of Frog Virus 3 infection on protein synthesis activity of mouse liver ribosomes. FEMS Letters 1: 13–16.
Elharrar-Pessah M, Petit D, Kirn A, et al. (1982) Alterations of plasma lipoproteins and hepatic lipid biosynthesi’s in FV 3-induced hepatitis in mice. Exp Mol Pathol 36: 118–128.
Granoff A, Came PE, Breeze DC (1966) Viruses and renal carcinoma of Rana pipiens. I. The isolation and properties of virus from normal and tumor tissue. Virology 29: 133–148.
Gut JP, Anton M, Bingen A, et al. (1981) Frog Virus 3 induces a fatal hepatitis in rats. Lab Invest 45: 218–228.
Gut JP, Schmitt S, Bingen A, et al. (1982) Protective effect of colectomy in Frog Virus 3 hepatitis of rats. Possibl-e role of endotoxin. J Infect Dis 146: 594–605.
Gut JP, Schmitt S, Bingen A, et al. (1984) Probable role of endogenous endotoxins in hepatocytolysis during murine hepatitis caused by Frog Virus 3. J Infect Dis 149: 621–629.
Gut JP, Steffan AM, Anton M, et al. (1980) Kupffer cell functions and Frog Virus 3 hepatitis in mice and rats. In: Liehr H, Grün M, eds. The Reticuloendothelial System and the Pathogenesis of Liver Disease. Amsterdam: Elsevier/North Holland Biomédical Press, 211–219.
Hagmann W, Denzlinger C, Keppler D (1984) Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action. Circ Shock 14: 223–235.
Hagmann W, Steffan AM, Kirn A, et al. (1987) Leukotrienes as mediators in Frog Virus 3-induced hepatitis in rats. Hepatology 7: 732–736.
Kirn A (1971) Pouvoir lethal pour la souris du virus 3 de la grenouille (FV 3). CR Acad Sci (D) (Paris) 272: 2504–2506.
Kirn A, Gut JP, Bingen A, et al. (1972) Acute hepatitis produced by Frog Virus 3 in mice. Arch Ges Virusforsch 36: 394–397.
Kirn A, Gut JP, Bingen A, et al. (1983) Murine hepatitis induced by Frog Virus 3: a model for studying the effect of sinusoidal cell damage on the liver. Hepatology 3: 105–111.
Kirn A, Gut JP, Steffan AM, et al. (1973/74) Immunization of mice against the toxic hepatitis produced by FV 3: inhibition of virus penetration into the liver. Intervirology 2: 244–252.
Kirn A, Steffan AM, Anton M, et al. (1978) Phagocytic properties displayed by mouse hepatocytes after virus-induced damage of the sinusoidal lining. Biomedicine 29: 25–28.
Nolan JP (1981) Endotoxin, reticuloendothelial function, and liver injury. Hepatology, 1: 458–465.
Steffan AM, Kirn A (1979) Multiplication of vaccinia virus in the livers of mice after Frog Virus 3-induced damage to sinusoidal cells. J Reticuloendothel Soc 26: 531–538.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Kirn, A., Gendrault, J.L., Steffan, A.M., Gut, J.P., Bingen, A. (1989). Murine Hepatitis Induced by Frog Virus 3 (FV3). In: Ahne, W., Kurstak, E. (eds) Viruses of Lower Vertebrates. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83727-2_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-83727-2_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83729-6
Online ISBN: 978-3-642-83727-2
eBook Packages: Springer Book Archive