Skip to main content
SpringerLink
Log in

Lipoprotein Lp(a): Structure and Metabolism

  • Conference paper
Book cover Cholesterol Transport Systems and Their Relation to Atherosclerosis

Part of the book series: Recent Developments in Lipid and Lipoprotein Research ((LIPID))

  • 403 Accesses

Abstract

The Lp(a) antigen was first detected in human plasma by Berg [1]. Although initially thought to represent a genetic variant of LDL, it was later shown to be associated with a specific lipoprotein fraction that is now commonly termed Lp(a) (for recent review see [2]). This lipoprotein has pre-β-mobility on zone electrophoresis as opposed to the β-mobility of LDL, and it has a higher hydrated density of 1.06–1.12 g/ml.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Berg K (1963) A new serum type system in man — the Lp system. Acta Pathol Microbiol Scand 59: 369–382.

    Article  PubMed  CAS  Google Scholar 

  2. Morrisett JD, Guyton JR, Gaubatz JW, Gotto AM (1987) Lipoprotein (a) structure, metabolism and epidemiology. In: Gotto AM (ed) Plasma lipoproteins. Elsevier, Amsterdam, pp 129–152

    Chapter  Google Scholar 

  3. Rhoads GG, Morton NE, Gulbrandson CL, Kagan A (1978) Sinking pre-beta lipoprotein and coronary heart disease in Japanese-American men in Hawaii. Am J Epidemiol 108: 350–356.

    PubMed  CAS  Google Scholar 

  4. Kostner GM, Avagaro P, Cazzalato G, Marth E, Bittolo-Bon G (1981) Lipoprotein Lp(a) and the risk for myocardial infarction. Atherosclerosis 38: 51–61.

    Article  PubMed  CAS  Google Scholar 

  5. Armstrong VW, Cremer P, Eberle E, Manke A, Schulze F, Wieland H, Kreuzer H, Seidel D (1986) The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis. Atherosclerosis 62: 249–257.

    Article  PubMed  CAS  Google Scholar 

  6. Dahlen GH, Guyton JR, Attar M, Farmer JA, Kautz JA, Gotto AM (1986) Association of levels of lipoprotein Lp(a), plasma lipids and other lipoproteins with coronary artery disease documented by angiography. Circulation 74: 758–765.

    Article  PubMed  CAS  Google Scholar 

  7. Rhoads GG, Dahlen GH, Berg K, Morton NE, Dannenberg AL (1986) Lp(a) Lipoprotein as a risk factor for myocardial infarction. JAMA 256: 2540–2544.

    Article  PubMed  CAS  Google Scholar 

  8. Murai A, Miyahara T, Fujimoto N, Matsuda M, Kameyama M (1986) Lp(a) Lipoprotein as a risk factor for coronary heart disease and myocardial infarction. Atherosclerosis 59: 199–204.

    Article  PubMed  CAS  Google Scholar 

  9. Utermann G, Weber W (1983) Protein composition of Lp(a) lipoprotein from human plasma. FEBS Lett 154: 357–361.

    Article  PubMed  CAS  Google Scholar 

  10. Gaubatz JW, Heidemann C, Gotto AM, Morrisett JD, Dahlen GH (1983) Human plasma lipoprotein (a) structural properties. J Biol Chem 258: 4582–4589.

    PubMed  CAS  Google Scholar 

  11. Fless GM, Rolih CH, Scanu AM (1984) Heterogeneity of human plasma Lipoprotein (a). J Biol Chem 259: 11470–11478.

    PubMed  CAS  Google Scholar 

  12. Armstrong VW, Walli AK, Seidel D (1985) Isolation, characterisation and aptake in human fibroblasts of an apo(a)-free lipoprotein obtained on reduction of lipoprotein (a) J Lipid Res 26: 1314–1323.

    PubMed  CAS  Google Scholar 

  13. Fless GM, Zum Mallen ME, Scanu AM (1985) Isolation of apolipoprotein (a) from lipoprotein (a). J Lipid Res 26: 1224–1229.

    Google Scholar 

  14. Gaubatz JW, Chari MV, Nava ML, Guyton JR, Morrisett JD (1987) Isolation and characterisation of the two major apoproteins in human lipoprotein (a). J Lipid Res 28: 69–79.

    PubMed  CAS  Google Scholar 

  15. Fless GM, Zum Mallen ME, Scanu AM (1986) Physiochemical properties of apolipoprotein (a) and Lipoprotein (a-) derived from the dissociation of human plasma lipoprotein (a). J Biol Chem 261: 8712–8718.

    PubMed  CAS  Google Scholar 

  16. Seman LJ, Breckenridge WC (1986) Isolation and partial characterisation of apolipoprotein (a) from human lipoprotein (a). Biochem Cell Biol 64: 999–1009.

    Article  PubMed  CAS  Google Scholar 

  17. Utermann G, Menzel HJ, Kraft HG, Duba HC, Kemmler HG, Seitz C (1987) Lp(a) glycoprotein phenotypes inheritance and relation to Lp(a)-lipoprotein concentrations in plasma. J Clin Invest 80: 458–465.

    Article  PubMed  CAS  Google Scholar 

  18. McLean JW, Tomlinson JE, Kuang W-J, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM (1987) cDNA sequence of human apolipoprotein (a) is homologous to plasminogen. Nature 300: 132–137.

    Article  Google Scholar 

  19. Eaton DL, Fless GM, Kohr WJ, McLean JW, Xu Q-T, Miller CG, Lawn RM, Scanu AM (1987) Partial amino acid sequence of apolipoprotein (a) shows that it is homologous to plasminogen. Proc Natl Acad Sci USA 84: 3224–3228.

    Article  PubMed  CAS  Google Scholar 

  20. Sottrup-Jensen L, Petersen TE, Magnusson S (1978) Serine proteases plasminogen-human Dayhoff MO (ed) National Biomedical Research Foundation, Washington DC. In: Atlas of protein sequence structure, vol 5, Suppl 3, p 91

    Google Scholar 

  21. Magnusson S, Petersen TE, Sottrup-Jensen L, Claeys H (1975) Complete primary structure of prothrombin isolation, structure and reactivity of ten carboxylated glutamic acid residuos and regulation of prothrombin activation by Thrombin. In: Reich E, Rifkin DB (eds) Proteases and biological control. Cold Spring Harbor, New York, pp 123–149

    Google Scholar 

  22. Pennica D, Holmes WE, Kohr WJ, Harkins RN, Vehar GA, Ward CA, Bennet WF, Yelverton E, Seeburg PH, Heyneker HL, Goeddel DV, Collen P (1983) Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature 301: 214–221.

    CAS  Google Scholar 

  23. Gunzler WA, Steffens GJ, Otting F, Kim S-M, Frankes E, Flohe L (1982) Structural relationship between human high and low molecular mass urokinase. Hoppe Seylers Z Physiol Chem 363: 1155–1165.

    Article  PubMed  CAS  Google Scholar 

  24. Cool DE, Edgell C-J, Louie GV, Zoller MJ, Brayer GD, MacGillivray RTA (1985) Characterisation of human blood coagulation factor XII cona. Prediction of the primary structure of factor XII and the tertiary structure of beta-factor XII a. J Biol Chem 260: 13666–13676.

    CAS  Google Scholar 

  25. Kratzin H, Armstrong VW, Niehaus M, Hilschmann N, Seidel D (1987) Structural relationship of an apolipoprotein (a) phenotype (570 kO) to plasminogen homologous kringle domains are linked by carbohydrate-rich regions. Biol Chem Hoppe Seyler 368: 1533–1544.

    Article  PubMed  CAS  Google Scholar 

  26. Malinowski DP, Sadler JE, Davie EW (1984) Characterisation of a complementary deoxyribonucleic acid coding for human and bovine plasminogen. Biochemistry 23: 4243–4250.

    Article  PubMed  CAS  Google Scholar 

  27. Kratzin H, Altevogt P, Ruban E, Kortt A, Staroscik K, Hilschmann N (1975) Die Primärstruktur eines monoklonalen IgA-Immunoglobulins (IgA Tro.) II. Die Aminosäuresequenz der H-Kette, alpha-Typ, Subgruppe III. Struktur des gesamten IgA-Molekuls. Hoppe Seylers Z Physiol Chem 356: 1337–1342.

    CAS  Google Scholar 

  28. Baenziger J, Kornfeld S (1974) Structure of the carbohydrate units of IgAl immunoglobulin. II Structure of the O-glycosidically Unked oligosaccharide units. J Biol Chem 249: 7270–7281.

    CAS  Google Scholar 

  29. Marth E, Cazzolato G, Bittolo-Bon G, Avogaro P, Kostner GM (1982) Serum concentrations of Lp(a) and other lipoproteine parameters in heavy alcohol consumers. Ann Nutr Metab 26: 56–62.

    Article  PubMed  CAS  Google Scholar 

  30. Bersot TP, Innerarity TL, Pitas RE, Rall SC, Weisgraber KH, Mahley RW (1986) Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein (a) and that cause lipid accumulation in macrophages. J clin Invest 77: 622–630.

    Article  PubMed  CAS  Google Scholar 

  31. Gilmore NJ, Moroz LA (1983) Plasminogen-binding lipoprotein isolation and characterization of a plasma very low density lipoprotein which co-chromatographs with plasminogen on lysine-sepharose. Thromb Res 31: 863–874.

    Article  PubMed  CAS  Google Scholar 

  32. Krempler F, Kostner GM, Roscher A, Haslauer F, Bolzano K, Sandhofer F (1983) Studies on the role of specific cell surface receptors in the removal of lipoprotein (a) in man. J Clin Invest 71: 1431–1441.

    Article  PubMed  CAS  Google Scholar 

  33. Havekes L, Vermeer BJ, Brugman T, Emeis J (1981) Binding of Lp(a) to the low density lipoprotein receptor of human fibroblasts. FEBS Lett 132: 169–173.

    Article  PubMed  CAS  Google Scholar 

  34. Floren C-H, Albers J, Biermann EL (1981) Uptake of Lp(a) lipoprotein by cultured Fibroblasts. Biochem Biophys Res Commun 102: 636–639.

    Article  PubMed  CAS  Google Scholar 

  35. Martmann-Moe K, Berg K (1981) Lp(a) lipoprotein enters cultured fibroblasts independently of the plasma membrane low density lipoprotein receptor. Clin Genet 20: 352–362.

    Article  Google Scholar 

  36. Vessby G, Kostner GM, Lithell H, Thomis J (1982) Diverging effects of cholestyramine on apolipoprotein B and lipoprotein (a). Atherosclerosis 44: 61–71.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. V. W. Armstrong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Kratzin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Seidel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung Endokrinologie und Stoffwechsel Zentrum Innere Medizin, Philipps-Universität, Baldinger Straße, 3550, Marburg, Federal Republic of Germany

    Armin Steinmetz , Hans Kaffarnik  & Jürgen Schneider ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Armstrong, V.W., Kratzin, H., Seidel, D. (1989). Lipoprotein Lp(a): Structure and Metabolism. In: Steinmetz, A., Kaffarnik, H., Schneider, J. (eds) Cholesterol Transport Systems and Their Relation to Atherosclerosis. Recent Developments in Lipid and Lipoprotein Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83665-7_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83665-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50548-8

  • Online ISBN: 978-3-642-83665-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation