Abstract
Apolipoprotein (apo) B containing lipoproteins and their remnants which are enriched in cholesterol are atherogenic in humans. These particles are metabolized by a complex process that is regulated by a number of different factors [1]. These include the assembly and secretion of triglyceride-rich apo B containing lipoprotein particles, intravascular lipolysis of the triglycerides, exchange of lipids and proteins between lipoprotein particles, and catabolism of the remnants of these apo B containing particles by receptor-mediated endocytosis. Two important modulating factors in the regulation of the catabolism of these remnants particles are apo E and the cell surface receptors with which it interacts.
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© 1989 Springer-Verlag Berlin Heidelberg
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Gregg, R.E., Zech, L.A., Gabelli, C., Brewer, H.B. (1989). Apolipoprotein E Modulates the Metabolism of Apolipoprotein B Containing Lipoproteins by Multiple Mechanisms. In: Steinmetz, A., Kaffarnik, H., Schneider, J. (eds) Cholesterol Transport Systems and Their Relation to Atherosclerosis. Recent Developments in Lipid and Lipoprotein Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83665-7_2
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DOI: https://doi.org/10.1007/978-3-642-83665-7_2
Publisher Name: Springer, Berlin, Heidelberg
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