Role of Apolipoprotein A-IV in Reverse Cholesterol Transport
Apolipoprotein (apo) A-IV was first described by Swaney and colleagues in 1974  in rat plasma high-density lipoprotein (HDL) and subsequently shown by a number of investigators to be an apoprotein component of lymph lipoproteins, plasma chylomicrons, very low density lipoproteins, and high-density lipoproteins and also to occur in a substantial amount unassociated with lipoproteins in a variety of mammalian species including man (for review see [22, 25]. Besides the liver the intestine is a major source of synthesis of this apoprotein . Whereas little is known about the hepatic synthesis of apo A-IV, the intestinal induction of this apoprotein has been studied in more detail. In primary cultures of nonproliferating rat hepatocytes dexamethasone and insulin increased apo A-IV mRNA substantially and could be shown to act synergistically when applied simultaneously .
KeywordsCholesterol Hydroxyl Electrophoresis Polypeptide Dexamethasone
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- 1.Apfelbaum TF, Davidson NO, Glickman RM (1987) Apolipoprotein A-IV synthesis in rat intestine regulation by dietary triglyceride. Am J Physiol 252: G662 G666Google Scholar
- 12.Dvorin E, Gorder NL, Benson DM, Gotto AM (1986) Apolipoprotein A-IV. A determinant for binding and uptake of high density lipoproteins by rat hepatocytes. J Biol Chem 261: 15714–15718.Google Scholar
- 16.Forte TM, Nichols AV, Krauss RM, Norum RA (1984) Familial apolipoprotein A-I and apolipoprotein C-III deficiency. Subclass distribution, composition, and morphology of lipoproteins in a disorder associated with premature atherosclerosis. J Clin Invest 74: 1601–1613.Google Scholar
- 18.Glickman RM, Perroto JL, Kirsch K (1976) Intestinal lipoprotein formation effect of cholchicine. Gastroenterolgy 7: 347–352.Google Scholar
- 26.Pessah M, Salvat C, Amit N, Infante R (1985) Isolation and characterization of rat intestinal polyribosomes and mRNA during absorption of fat. Increased translation in vitro of apo A-IV Biochem Biophys Res Commun 126: 373–381.Google Scholar
- 34.Steinmetz A, Utermann G (1983) Human apolipoprotein A-IV activates lecithin cholesterol acyltransferase (abstract). Arteriosclerosis 3 490a (abstract)Google Scholar