Role of Apolipoprotein A-IV in Reverse Cholesterol Transport

  • A. Steinmetz
Conference paper
Part of the Recent Developments in Lipid and Lipoprotein Research book series (LIPID)


Apolipoprotein (apo) A-IV was first described by Swaney and colleagues in 1974 [37] in rat plasma high-density lipoprotein (HDL) and subsequently shown by a number of investigators to be an apoprotein component of lymph lipoproteins, plasma chylomicrons, very low density lipoproteins, and high-density lipoproteins and also to occur in a substantial amount unassociated with lipoproteins in a variety of mammalian species including man (for review see [22, 25]. Besides the liver the intestine is a major source of synthesis of this apoprotein [38]. Whereas little is known about the hepatic synthesis of apo A-IV, the intestinal induction of this apoprotein has been studied in more detail. In primary cultures of nonproliferating rat hepatocytes dexamethasone and insulin increased apo A-IV mRNA substantially and could be shown to act synergistically when applied simultaneously [13].


Cholesteryl Ester Cholesteryl Ester Transfer Protein Reverse Cholesterol Transport Acyl Donor Bovine Aortic Endothelial Cell 
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© Springer-Verlag Berlin Heidelberg 1989

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  • A. Steinmetz

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