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Role of Apolipoprotein A-IV in Reverse Cholesterol Transport

  • A. Steinmetz
Conference paper
Part of the Recent Developments in Lipid and Lipoprotein Research book series (LIPID)

Abstract

Apolipoprotein (apo) A-IV was first described by Swaney and colleagues in 1974 [37] in rat plasma high-density lipoprotein (HDL) and subsequently shown by a number of investigators to be an apoprotein component of lymph lipoproteins, plasma chylomicrons, very low density lipoproteins, and high-density lipoproteins and also to occur in a substantial amount unassociated with lipoproteins in a variety of mammalian species including man (for review see [22, 25]. Besides the liver the intestine is a major source of synthesis of this apoprotein [38]. Whereas little is known about the hepatic synthesis of apo A-IV, the intestinal induction of this apoprotein has been studied in more detail. In primary cultures of nonproliferating rat hepatocytes dexamethasone and insulin increased apo A-IV mRNA substantially and could be shown to act synergistically when applied simultaneously [13].

Keywords

Cholesteryl Ester Cholesteryl Ester Transfer Protein Reverse Cholesterol Transport Acyl Donor Bovine Aortic Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1989

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  • A. Steinmetz

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