Ribosomal Protein S6 Kinase and PKC in Human Mammary Tumor Cells

  • D. Fabbro
  • I. Novak-Hofer
  • W. Küng
  • T. Meyer
  • A. Matter
  • U. Eppenberger
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 113)


It is well established that 17-β estradiol (E2) influences the growth of human breast cancer (Patterson et al. 1982; Edwards et al. 1979; Maass and Jonat 1983; Howat et al. 1985), but it is unclear wheter E2 acts directly or indirectly on the proliferation of target cells (Soto and Sonnenschein 1987; Dickson and Lippman 1987; King 1985). At present, there is increasing evidence that polypeptide growth factors (GF) also regulate the growth of human breast cancer (Dickson and Lippman 1987; King 1985; Dickson et al. 1986; Dickson et al. 1986). Therefore, E2 may in part promote the growth through the regulation of autostimulatory and autoinhibitory GFs (Soto and Sonnenschein 1987; Dickson and Lippman 1987; Knabbe et al. 1987). Consequently, the hormone dependency of breast tumor cells may be limited not only to functional estrogen receptors (ER) but also to functional growth factor receptors (GF-R). Such GF-Rs are likely to represent important growth-regulatory elements in the estrogen-induced autocrine or paracrine growth mechanisms of human breast cancer (Fitzpatrick et al. 1984; Macias et al. 1986; Sainsbury et al. 1985; Wyss et al. 1987; Sainsbury et al. 1987; Furlanetto and DiCarlo 1984).


Epidermal Growth Factor Receptor Human Breast Cancer Cell Human Breast Cancer Cell Line Mammary Tumor Cell Epidermal Growth Factor Binding 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • D. Fabbro
    • 1
  • I. Novak-Hofer
    • 1
  • W. Küng
    • 1
  • T. Meyer
    • 2
  • A. Matter
    • 2
  • U. Eppenberger
    • 1
  1. 1.Laboratorien, Kantonsspital BaselUniversitäts-FrauenklinikBaselSwitzerland
  2. 2.CiBA-GEIGYBaselSwitzerland

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