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Ribosomal Protein S6 Kinase and PKC in Human Mammary Tumor Cells

  • D. Fabbro
  • I. Novak-Hofer
  • W. Küng
  • T. Meyer
  • A. Matter
  • U. Eppenberger
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 113)

Abstract

It is well established that 17-β estradiol (E2) influences the growth of human breast cancer (Patterson et al. 1982; Edwards et al. 1979; Maass and Jonat 1983; Howat et al. 1985), but it is unclear wheter E2 acts directly or indirectly on the proliferation of target cells (Soto and Sonnenschein 1987; Dickson and Lippman 1987; King 1985). At present, there is increasing evidence that polypeptide growth factors (GF) also regulate the growth of human breast cancer (Dickson and Lippman 1987; King 1985; Dickson et al. 1986; Dickson et al. 1986). Therefore, E2 may in part promote the growth through the regulation of autostimulatory and autoinhibitory GFs (Soto and Sonnenschein 1987; Dickson and Lippman 1987; Knabbe et al. 1987). Consequently, the hormone dependency of breast tumor cells may be limited not only to functional estrogen receptors (ER) but also to functional growth factor receptors (GF-R). Such GF-Rs are likely to represent important growth-regulatory elements in the estrogen-induced autocrine or paracrine growth mechanisms of human breast cancer (Fitzpatrick et al. 1984; Macias et al. 1986; Sainsbury et al. 1985; Wyss et al. 1987; Sainsbury et al. 1987; Furlanetto and DiCarlo 1984).

Keywords

Epidermal Growth Factor Receptor Human Breast Cancer Cell Human Breast Cancer Cell Line Mammary Tumor Cell Epidermal Growth Factor Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • D. Fabbro
    • 1
  • I. Novak-Hofer
    • 1
  • W. Küng
    • 1
  • T. Meyer
    • 2
  • A. Matter
    • 2
  • U. Eppenberger
    • 1
  1. 1.Laboratorien, Kantonsspital BaselUniversitäts-FrauenklinikBaselSwitzerland
  2. 2.CiBA-GEIGYBaselSwitzerland

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