Abstract
Many cells assume various polarized shapes in vivo depending on their genetic program and their interaction with the environment consisting of neighbouring cells, intercellular matrix elements and signal molecules. Some of these processes can be reproduced in cell culture systems. The adoption of an asymmetric polarized cell shape involves active deformation and motility. This is generated by the interaction of cytoplasmic force generating molecules with membrane embedded components which transmit the forces onto the extracellular matrix. Order and polarity is also displayed within the cells interior by the non-random distribution of various organelles such as Golgi elements, lysosomes, mitochondria etc. This is predominantly dependent on dynamic interactions between the membrane-lined organelles and the microtubule system. The intracellular polarity is most often related to the polarity generated by the cells motile activity. Membrane components are exchanged continuously between the cell membrane and the intracellular compartments.
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De Brabander, M., Nuydens, R., Geerts, H. (1990). Dynamic Cytomatrix-Membrane Interactions in Cell Shape and Organization. In: Akkaş, N. (eds) Biomechanics of Active Movement and Deformation of Cells. NATO ASI Series, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83631-2_7
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DOI: https://doi.org/10.1007/978-3-642-83631-2_7
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