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Three Position Controller for Tensile Regulation of Axon Length

  • Robert E. Buxbaum
  • Steven R. Heidemann
Conference paper
Part of the NATO ASI Series book series (volume 42)

Abstract

Some evidence suggests that mechanical tension is a regulator of axonal length in both growth and retraction. The last phase of axonal growth was described by Weiss (1941) as “towing.” The tension exerted by the migration of the neuron’s target cell in the expanding animal embryo causes the attached axon to elongate. Bray (1984) showed that a similar process of tension-induced axonal elongation would occur in cultured neurons whose neurites were attached to a towing motor. Elimination of supernumerary axons in the development of skeletal muscle innervation (Purves and Lichtman 1980) occurs by axonal retraction, not degeneration (Riley 1981), indicating the presence of axonal tension to withdraw the supernumerary axons. Campenot (1985) found evidence for tension regulation in neurite length by adding or substracting nerve growth factor to ifferent regions of cultured neurons.

Keywords

PC12 Cell Growth Cone Axonal Growth Neurite Length Applied Tension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature Cited

  1. Black, M.M. 1987. Taxol interferes with the interaction of microtubule-associated proteins with microtubules in cultured neurons. J. Neurosci. 7: 3695–3702.PubMedGoogle Scholar
  2. Bray, D. 1984. Axonal growth in response to experimentally applied tension. Develop. Biol. 102: 379–389.PubMedCrossRefGoogle Scholar
  3. Bridgman, P.C. and M.E. Dailey. 1989. The organization of myosin and actin in rapid frozen nerve growth cones. J. Cell Biol. 108: 95–109.PubMedCrossRefGoogle Scholar
  4. Campenot, R.B. 1985. The regulation of nerve fiber length by interacalated elongation and retraction. Devel. Brain Res. 20: 149–154.CrossRefGoogle Scholar
  5. Dennerll, T.J., H.C. Joshi, V.L. Steel, R.E. Buxbaum, and S.R. Heidemann. 1988. Tension and compression in the cytoskeleton: II Quantitative masurements. J. Cell Biol. 107: 665–664.PubMedCrossRefGoogle Scholar
  6. Kuczmarski, E.R. and J.L. Rosenbaum. 1979. Studies on the organization and localization of actin an myosin in neurons. J. Cell Biol. 80: 356–371.PubMedCrossRefGoogle Scholar
  7. Lamoureux, P., R.E. Buxbaum, and S.R. Heidemann. 1989. Direct evidence that growth cones pull. Nature (London) 340: 159–162.CrossRefGoogle Scholar
  8. Purves, D. and J.W. Lichtman. 1980. Elimination of synapses in the developing nervous system. Science 210: 153–157.PubMedCrossRefGoogle Scholar
  9. Riley, D.A. 1981. Ultrastructural evidence for axon retraction during spontaneous elimination of polyneural innervation of the rat soleus muscle. J. Neurocytol. 10: 425–440.PubMedCrossRefGoogle Scholar
  10. Weiss, P. 1941. Nerve Pattern: The mechanics of nerve growth. Growth (Suppl. Third Growth Symp.) 5: 163–203.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Robert E. Buxbaum
    • 1
  • Steven R. Heidemann
    • 1
  1. 1.Departments of Physiology and Chemical EngineeringMichigan State UniversityE. LansingUSA

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