Abstract
A segmental defect model has been developed in the rat and used to evaluate a variety of bone graft materials both alone and as part of composite graft materials. These include: fibrillar collagen (FC), lyophilized fibrillar collagen (LFC), air-dried fibrillar collagen (ADFC), trypsinized demineralized bone powder (TBP), 0.5 mm hydroxyapatite-tricalcium phosphate ceramic granules (HA/ TCP), bone marrow (BM), and cancellous bone (CB). In addition, a bone-derived protein fraction (15–30K) which includes bone morphogenetic protein (BMP) and transformation growth factor beta was combined with TBP to form a reconstituted demineralized bone matrix (RDBM) material (approximately 1 mg/defect).
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© 1989 Springer-Verlag, Berlin Heidelberg
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Muschler, G.F. et al. (1989). Segmental Femoral Defect Model in the Rat. In: Aebi, M., Regazzoni, P. (eds) Bone Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83571-1_25
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DOI: https://doi.org/10.1007/978-3-642-83571-1_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83573-5
Online ISBN: 978-3-642-83571-1
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