Abstract
It is our intention to discuss briefly some of the possible consequences of reperfusing myocytes which have been ischemic. (For a more detailed discussion of this subject, the reader is referred to [1 – 3].) At the outset, one must understand that ischemic myocardium is heterogenous. Thus, different myocytes even within the same ischemic region may be affected quite differently by reperfusion. The principal determinants of the myocardial response to reperfusion are (a) the duration of ischemia and (b) the severity of ischemia. By severity of ischemia we refer here to the degree to which collateral blood flow is inadequate to provide for the metabolic demands of the myocardium.
Supported in part by NIH grants HL27416 and HL23138.
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References
Reimer KA, Jennings RB (1986) Myocardial ischemia, hypoxia, and infarction. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE (eds) The heart and cardiovascular system. Raven Press, New York, pp 1133–1201
Reimer KA, Ideker RE (1987) Myocardial ischemia and infarction: anatomic and biochemical substrates for ischemic cell death and ventricular arrhythmias. Hum Pathol 18: 462–475
Uraizee A, Reimer KA, Murry CE, Jennings RB (1987) Failure of superoxide dismutase to limit myocardial infarct size in a 40 minutes ischemia/four days reperfusion model in dogs. Circulation 75: 1237–1248
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© 1988 Springer-Verlag Berlin Heidelberg
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Reimer, K.A., Jennings, R.B. (1988). Reperfusion Injury. In: Schettler, G., Jennings, R.B., Rapaport, E., Wenger, N.K., Bernhardt, R. (eds) Reperfusion and Revascularization in Acute Myocardial Infarction. Supplement zu den Sitzungsberichten der Mathematisch-naturwissenschaftlichen Klasse Jahrgang 1988, vol 1988 / 1988/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83544-5_6
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DOI: https://doi.org/10.1007/978-3-642-83544-5_6
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