Abstract
Treatment of acute myocardial infarction with plasminogen activators reduces infarct size and mortality [1]. However, this form of therapy has been attended by significant problems. Urokinase and streptokinase lack fibrin selectivity and promote generalized fibrinogenolysis, at times resulting in severe bleeding [2]. Tissue-type plasminogen activator (TPA) and single-chain urokinase-type plasminogen activator (prourokinase) are both reported to be more clot-specific [3, 4]. In contrast to TPA, relatively few patients have been treated with prourokinase, and therefore experience with respect to the fibrin specificity and thrombolytic efficacy of this drug in a clinical situation is limited [5, 6, 7]. This study was undertaken in order to prove whether or not prourokinase is an effective, clot-selective fibrinolytic agent in patients with acute myocardial infarction.
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© 1988 Springer-Verlag Berlin Heidelberg
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Bode, C. et al. (1988). Prourokinase in Acute Myocardial Infarction: Is it Effective?. In: Schettler, G., Jennings, R.B., Rapaport, E., Wenger, N.K., Bernhardt, R. (eds) Reperfusion and Revascularization in Acute Myocardial Infarction. Supplement zu den Sitzungsberichten der Mathematisch-naturwissenschaftlichen Klasse Jahrgang 1988, vol 1988 / 1988/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83544-5_14
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DOI: https://doi.org/10.1007/978-3-642-83544-5_14
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