Abstract
A large and convincing body of evidence links coronary risk with elevated plasma levels of both low-density lipoprotein (LDL) cholesterol and fibrinogen. Cholesterol in atherosclerotic lesions originates mainly from cholesterol circulating in the blood bound to LDL. Most forms of hyper-β-lipoproteinemia result from a defect in extraction of LDL from plasma by the liver, and the LDL receptor is now being recognized as the crucial element in the control of cholesterol homeostasis [1]. Elevated levels of fibrinogen, a common phenomenon in hypercholesterolemia increases the viscosity of the blood and thereby further alters perfusion of tissues in severe atherosclerotic disease. Furthermore, fibrinogen and its degradation products can both influence prostaglandin metabolism by inhibiting PGI2 synthesis by endothelial and vascular smooth muscle cells, thereby facilitating platelet aggregation, and can also cause injury to endothelial cells.
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References
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© 1988 Springer-Verlag Berlin Heidelberg
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Seidel, D. (1988). Extracorporal Plasma Therapy in the Treatment of Severe Hyper-β-lipoproteinemia: The HELP System. In: Schettler, G., Jennings, R.B., Rapaport, E., Wenger, N.K., Bernhardt, R. (eds) Reperfusion and Revascularization in Acute Myocardial Infarction. Supplement zu den Sitzungsberichten der Mathematisch-naturwissenschaftlichen Klasse Jahrgang 1988, vol 1988 / 1988/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83544-5_12
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DOI: https://doi.org/10.1007/978-3-642-83544-5_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83546-9
Online ISBN: 978-3-642-83544-5
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