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Neurotoxic Effects of Ethidium Bromide, Rat

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Book cover Nervous System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Pathologic lesions are produced by a direct exposure of the central and peripheral nervous tissues to ethidium bromide which is a red dye. Therefore the lesion appears red or reddish-orange and softer than the surrounding tissue.

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References

  • Albring M, Radsak K, Thoenes W (1973) Giant mitochondria. II. Induction of matrix enriched megamitochondria in mouse liver parenchymal cells by ethidium bromide. Virchows Arch [B] 14: 373–377

    CAS  Google Scholar 

  • Aleu FP, Katzman R, Terry RD (1963) Fine structure and electrolyte analyses of cerebral edema induced by alkyl tin intoxication. J Neuropathol Exp Neurol 22: 403–413

    Article  CAS  PubMed  Google Scholar 

  • Bengtsson A, Grimelius L, Johansson H, Ponten J (1977) Nuclear DNA-content of parathyroid cells in adenomas, hyperplastic and normal glands. Acta Pathol Microbiol Scand [A] 85: 455–460

    CAS  Google Scholar 

  • Blakemore WF (1982) Ethidium bromide induced demyelination in the spinal cord of the cat. Neuropathol Appl Neurobiol 8: 365–375

    Article  CAS  PubMed  Google Scholar 

  • Blakemore WF, Palmer AC, Noel PRB (1972) Ultrastructural changes in isoniazid-induced brain edema in the dog. J Neurocytol 1: 263–278

    Article  CAS  PubMed  Google Scholar 

  • Browlee G, Gross MD, Goodwin LG, Woodbine M, Wall LP (1950) The chemotherapeutic action of phenanthridine compounds. Br J Pharmacol 5: 261–275

    Google Scholar 

  • Cesarini K, Atillo A, Brigotte L, Hussain ST, Olsson Y (1985) Cytofluorescence localization of ethidium bromide in the nervous system of the mouse. I. Ethidium bromide: its distribution in regions within and without the blood-brain barrier after intravenous injection. Acta Neuropathol (Berl) 68: 273–278

    Article  CAS  PubMed  Google Scholar 

  • Lampert PW, O’Brien J, Garrett R (1973) Hexachlorophene encephalopathy. Acta Neuropathol (Berl) 23: 326–333

    Article  CAS  PubMed  Google Scholar 

  • Leibowitz RD (1971) The effect of ethidium bromide on mitochondrial DNA synthesis and mitochondrial DNA structure in HeLa cells. J Cell Biol 51:116–122

    Article  CAS  PubMed  Google Scholar 

  • Ludwin SK (1981) Pathology of demyelination and remyelination. In: Waxman SG, Ritchie JM (eds) Demyelinating disease: basic and clinical electrophysiology. Raven, New York, pp 123–168

    Google Scholar 

  • McGill M, Hsu TC, Brinkley BR (1973) Electron-dense structures in mitochondria induced by short-term ethidium bromide treatment. J Cell Biol 59: 260–265

    Article  CAS  PubMed  Google Scholar 

  • Meier C, Bischoff A (1974) Dysmyelination in “jimpy” mouse. Electron microscopic study. J Neuropathol Exp Neurol 33: 343–353

    Article  CAS  PubMed  Google Scholar 

  • Plumbridge TW, Brown JF (1977) Spectrophotometric and fluorescence polarization studies of the binding of ethidium, daunomycin and mepacrine to DNA and to poly(IC). Biochim Biophys Acta 479: 441–449

    Article  CAS  PubMed  Google Scholar 

  • Smith PJS, Leech CA, Treherne JE (1984) Glial repair in an insect central nervous system: effects of selective glial disruption. J Neurosci 4: 2698–2711

    CAS  PubMed  Google Scholar 

  • Soslau G, Nass MMK (1971) Effects of ethidium bromide on the cytochrome content and ultrastructure of L-cell mitochondria. J Cell Biol 51: 514–524

    Article  CAS  PubMed  Google Scholar 

  • Suzuki K (1969) Giant hepatic mitochondria: production in mice fed with cuprizone. Science 163: 81–82

    Article  CAS  PubMed  Google Scholar 

  • Suzuki K, Kikkawa Y (1969) Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone). Am J Pathol 54: 307–325

    CAS  PubMed  Google Scholar 

  • Suzuki K, Zagoren JC (1974) Degeneration of Oligodendroglia in the central nervous system of rats treated with AY9944 or triparanol. Lab Invest 31: 503–515

    CAS  PubMed  Google Scholar 

  • Woolfe G (1952) The trypanocidal action of phenanthridine compounds. Ann Trop Med Parasitol 46: 285–296

    CAS  PubMed  Google Scholar 

  • Yajima K, Suzuki K (1979 a) Ultrastructural changes of Oligodendroglia and myelin sheaths induced by ethidium bromide. Neuropathol Appl Neurobiol 5: 49–62

    Article  CAS  PubMed  Google Scholar 

  • Yajima K, Suzuki K (1979 b) Demyelination and remyelination in the rat central nervous system following ethidium bromide injection. Lab Invest 41: 385–392

    CAS  PubMed  Google Scholar 

  • Zylber E, Vesco C, Penman S (1969) Selective inhibition of the synthesis of mitochondria-associated RNA by ethidium bromide. J Mol Biol 44: 195–204

    Article  CAS  PubMed  Google Scholar 

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Authors
  1. Kinuko Suzuki
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Editors and Affiliations

  1. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology, Emeritus) & Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology, Emeritus) &  (Professor of Comparative Pathology)

  2. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

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© 1988 Springer-Verlag Berlin Heidelberg

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Suzuki, K. (1988). Neurotoxic Effects of Ethidium Bromide, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Nervous System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83516-2_8

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  • DOI: https://doi.org/10.1007/978-3-642-83516-2_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83518-6

  • Online ISBN: 978-3-642-83516-2

  • eBook Packages: Springer Book Archive

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