Neurotoxic Effects of Doxorubicin, Rat

  • Bernhard S. Jortner
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Gross lesions have not been noted. Doxorubicin (Adriamycin) is a glycosidic anthracycline antibiotic comprised of a tetracycline ring structure with the sugar daunosamine attached by a glycosidic linkage. Neurotoxicity has been demonstrated in young rats (250–350 g) given 10 mg/kg doxorubicin intravenously. These rats develop progressive limb ataxia and dyssynergia at about 11–12days. Involvement of hindlimbs occurs earlier and is the more prominent sign (Fig.21) (Cho 1977).

Synonym

Adriamycin neurotoxicity 

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© Springer-Verlag Berlin Heidelberg 1988

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  • Bernhard S. Jortner

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