Abstract
The cerebellum of the weaver mouse is abnormally small and is about one-fourth the size of the cerebellum in the normal littermates (Sidman et al. 1965).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Altman J, Anderson WJ (1972) Experimental reorganization of the cerebellar cortex. I. Morphological effects of elimination of microneurons with prolonged X-irradiation started at birth. J Comp Neurol 146: 355–406
Gupta M, Feiten DL, Ghetti B (1987) Selective loss of monoaminergic neurons in weaver mutant mice-an immunocytochemical study. Brain Res 402: 379–382
Hanna RB, Hirano A, Pappas GD (1976) Membrane specializations of dendritic spines and glia in the weaver mouse cerebellum. A freeze-fracture study. J Cell Biol 68:403–410
Herndon RM, Margolis G, Kilham L (1971) The synaptic organization of the malformed cerebellum induced by perinatal infection with the feline panleukopenia virus (PLV). II. The Purkinje cell and its afferents. J Neuropathol Exp Neurol 30: 557–570
Hirano A (1979) On the independent development of the pre-and postsynaptic terminals. Prog Neuropathol 4: 79–99
Hirano A, Dembitzer HM (1973) Cerebellar alterations in the weaver mouse. J Cell Biol 56: 478–486
Hirano A, Dembitzer HM (1974) Observations on the development of the weaver mouse cerebellum. J Neuropathol Exp Neurol 33: 354–364
Hirano A, Dembitzer HM (1975 a) The fine structure of staggerer cerebellum. J Neuropathol Exp Neurol 34: 1–11
Hirano A, Dembitzer HM (1975 b) Aberrant development of the Purkinje cell dendritic spine. Adv Neurol 12: 353–360
Hirano A, Dembitzer HM (1976) The fine structure of astrocytes in the adult staggerer. J Neuropathol Exp Neurol 35:63–74
Hirano A, Shin WY (1979) Unattached presynaptic terminals in a cerebellar neuroblastoma in the human. Neuropathol Appl Neurobiol 5: 63–70
Hirano A, Zimmerman HM (1973) Aberrant synaptic development. A review. Arch Neurol 28: 359–366
Hirano A, Dembitzer HM, Jones M (1972) An electron microscopic study of cycasin-induced cerebellar alterations. J Neuropathol Exp Neurol 31: 113–125
Hirano A, Dembitzer HM, Ghatak NR, Fan KJ, Zimmerman HM (1973) On the relationship between human and experimental granule cell type cerebellar degeneration. J Neuropathol Exp Neurol 32: 493–502
Hirano A, Llena JF, French JH, Ghatak NR (1977 a) Fine structure of the cerebellar cortex in Menkes kinky-hair disease. X-chromosome-linked copper malabsorption. Arch Neurol 34: 52–56
Hirano A, Dembitzer HM, Yoon CH (1977 b) Development of Purkinje cell somatic spines in the weaver mouse. Acta Neuropathol (Berl) 40: 85–90
Hirano I, Shibuya C, Hayashi K (1969) Induction of a cerebellar disorder with cycasin in newborn mice and hamsters. Proc Soc Exp Biol Med 131: 593–599
Iwata M, Hirano A, French JH (1979 a) Thalamic degeneration in X-chromosome-linked copper malabsorption. Ann Neurol 5: 359–366
Iwata M, Hirano A, French JH (1979b) Degeneration of the cerebellar system in X-chromosome-linked copper malabsorption. Ann Neurol 5: 542–549
Landis DMD, Sidman RL (1974) Cerebellar cortical development in the staggerer mouse. J Neuropathol Exp Neurol 33: 180
Purpura DP, Hirano A, French JH (1976) Polydendritic Purkinje cells in X-chromosome-linked copper malabsorption. A Golgi study. Brain Res 117: 125–129
Rakic P, Sidman RL (1973) Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice. J Comp Neurol 152: 133–162
Schmidt MJ, Sawyer BD, Perry KW, Fuller FR, Foreman MM, Ghetti B (1982) Dopamine deficiency in the weaver mutant mouse. J Neurosci 2: 376–380
Shin WY, Laufer H, Lee YC, Aftalion B, Hirano A, Zimmerman HM (1978) Fine structure of a cerebellar neuroblastoma. Acta Neuropathol (Berl) 42: 11–13
Sidman RL, Green MC, Appel SH (1965) Catalog of the neurological mutants of the mouse. Harvard University Press, Cambridge
Sotelo C (1973) Permanence and fate of paramembranous synaptic specializations in “mutant” and experimental animals. Brain Res 62: 345–351
Triarhou LC, Low WC, Ghetti B (1986) Transplantation of ventral mesencephalic anlagen to hosts with genetic nigrostriatal dopamine deficiency. Proc Natl Acad Sci USA 83:8789–8793
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hirano, A., Shintaku, M. (1988). Aberrant Synaptic Development in Mutant “Weaver” Mice. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Nervous System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83516-2_37
Download citation
DOI: https://doi.org/10.1007/978-3-642-83516-2_37
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83518-6
Online ISBN: 978-3-642-83516-2
eBook Packages: Springer Book Archive