Neurotoxic Effects of Lysolecithin, Mouse, Rat

  • Susan M. Hall
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Experimental lesions are produced by the injection of varying amounts of lysolecithin directly into the central nervous system or peripheral nerves. The sites and techniques of injection will be described in following sections of this report. Gross lesions are not usually observed.


Lysolecithin lysophosphatidyl choline (LPC) 


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  1. Balentine JD (1978) Pathology of experimental spinal cord trauma. II. Ultrastructure of axons and myelin. Lab Invest 39: 254–266PubMedGoogle Scholar
  2. Blakemore WF (1976) Invasion of Schwann cells into the spinal cord of the rat following local injection of lysolecithin. Neuropathol Appl Neurobiol 2: 21–39CrossRefGoogle Scholar
  3. Blakemore WF (1978) Observations on remyelination in the rabbit spinal cord following demyelination induced by lysolecithin. Neuropathol Appl Neurobiol 4: 47–59CrossRefPubMedGoogle Scholar
  4. Blakemore WF, Eames RA, Smith KJ, McDonald WI (1977) Remyelination in the spinal cord of the cat following intraspinal injections of lysolecithin. J Neurol Sci 33:31–43CrossRefPubMedGoogle Scholar
  5. Blight AR (1985) Delayed demyelination and macrophage invasion: a candidate for secondary cell damage in spinal cord injury. Cent Nerv Syst Trauma 2: 299–315PubMedGoogle Scholar
  6. Birkmayer W, Neumayer E (1957) Experimentelle Untersuchungen zur Frage der formalen Pathogenese der Multiple Sclerosia. Dtsch Z Nervenheilkd 177:117–125PubMedGoogle Scholar
  7. DalCanto M, Wisniewski HM, Johnson AB, Brostoff SW, Raine CS (1975) Vesicular disruption of myelin in autoimmune demyelination. J Neurol Sci 24: 313–319CrossRefPubMedGoogle Scholar
  8. Gregson NA (1976) The chemistry and structure of myelin. In: Landon DN (ed) The peripheral nerve. Chapman and Hall, London, pp 512–604Google Scholar
  9. Gregson NA, Hall SM (1973) A quantitative analysis of the effects of the intraneural injection of lysophosphatidyl choline. J Cell Sci 13: 257–277PubMedGoogle Scholar
  10. Hahn AF, Gilbert JJ, Feasby TE (1980) Passive transfer of demyelination by experimental allergic neuritis serum. Acta Neuropathol (Berl) 49:169–176CrossRefPubMedGoogle Scholar
  11. Hall SM (1972) The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord. J Cell Sci 10: 535–546PubMedGoogle Scholar
  12. Hall SM (1973) Some aspects of remyelination after demyelination produced by the intraneural injection of lysophosphatidyl choline. J Cell Sci 13: 461–477PubMedGoogle Scholar
  13. Hall SM, Gregson NA (1971) The in vivo and ultrastructural effects of injection of lysophosphatidyl choline into myelinated peripheral nerve fibres of the adult mouse. J Cell Sci 9: 769–789PubMedGoogle Scholar
  14. Hildebrand C, Mustafa GY, Waxman SG (1986) Remodelling of internodes in regenerated rat sciatic nerve: electron microscopic observations. J Neurocytol 15: 681–692CrossRefPubMedGoogle Scholar
  15. Lampert PW (1965) Demyelination and remyelination in experimental allergic encephalitis. Further electronmicroscopic observations. J Neuropathol Exp Neurol 24: 371–385CrossRefGoogle Scholar
  16. Marburg O (1906) Syringomyelic und Halsnippe. Wien Klin Wochenschr 20: 241–244Google Scholar
  17. Mitchell J, Caren CA (1982) Degeneration of non-myelinated axons in the rat sciatic nerve following lysolecithin injection. Acta Neuropathol (Berl) 56:187–193CrossRefPubMedGoogle Scholar
  18. Morrison LR, Zamecnik PC (1950) Experimental demyelination by means of enzymes, especially the alpha toxin of Clostridium welchii. Arch Neurol Psychiatry 63: 367–381CrossRefGoogle Scholar
  19. Prineas JW (1972) Acute idiopathic polyneuritis: an electron microscope study. Lab Invest 26:133–147PubMedGoogle Scholar
  20. Raine CS (1984) Analysis of autoimmune demyelination: its impact upon multiple sclerosis. Lab Invest 50: 608–635PubMedGoogle Scholar
  21. Saida K, Saida T, Brown MJ, Silberberg DH, Asbury AK (1978) Antiserum-mediated demyelination in vivo. A sequential study using intraneural injection of experimental allergic neuritis serum. Lab Invest 39: 449–462PubMedGoogle Scholar
  22. Saida K, Saida T, Brown MJ, Silberberg DH (1979) In vivo demyelination induced by intraneural injection of antigalactocerebroside serum. A morphologic study. Am J Pathol 95:99–116PubMedGoogle Scholar
  23. Schlaepfer WW (1977) Vesicular disruption of myelin simulated by exposure of nerve to calcium ionophore. Nature 26: 734–736CrossRefGoogle Scholar
  24. Smith KJ, Hall SM, Schauf CL (1983) Vesicular demyelination induced by raised intracellular calcium. J Neurol Sci 71:19–37CrossRefGoogle Scholar
  25. Smith ME, Benjamins JA (1977) Model systems for study of perturbations of myelin metabolism. In: Morell P (ed) Myelin. Plenum, New York, pp 447–488Google Scholar
  26. Thompson RHS (1961) Myelinolytic mechanisms. Symposium on disseminated sclerosis. Proc R Soc Med 54: 30–33PubMedGoogle Scholar
  27. Trotter J, Smith ME (1986) The role of phospholipases from inflammatory macrophages in demyelination. Neurochem Res 11: 349–361CrossRefPubMedGoogle Scholar
  28. Waxman SG, Kocsis JD, Nitta KC (1979) Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum. Light microscopic observations. J Neurol Sci 44: 45–53CrossRefPubMedGoogle Scholar
  29. Webster GR (1957) Clearing action of lysolecithin onbrain homogenates. Nature 180: 660–661CrossRefPubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1988

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  • Susan M. Hall

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