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Lecithin: Cholesterol Acyl Transferase, Cholesterol Ester Exchange/Transfer Protein, and Lipoprotein Particles

  • G. M. Kostner
  • E. Steyrer
Conference paper
Part of the Recent Developments in Lipid and Lipoprotein Research book series (LIPID)

Abstract

More than 80% of the cholesteryl esters (CE) found in human plasma derive from the reaction of lecithin: cholesterol acyl transferase (LCAT). Since the content of CE in plasma high positively correlates with the incidence of atherosclerosis and myocardial infarction, there has been in the past and still is great interest in investigation of the enzymes involved in lipoprotein metabolism. This overview summarizes some general features, with particular emphasis on investigations carried out in our laboratory: (a) the substrates of LCAT in plasma; (b),the influence of LCAT on the lipoprotein spectrum; (c) the distribution of formed CE after the action of LCAT; (d) the impact of eholesteryl ester transfer/exchange protein (CETP) on lipoprotein metabolism.

Keywords

Cholesteryl Ester Lipoprotein Metabolism Core Lipid Cholesterol Acyl Transferase Cholesteryl Ester Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • G. M. Kostner
  • E. Steyrer

There are no affiliations available

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