Abstract
The human organism needs a continuous supply of oxygen to maintain its specific cell functions under different working conditions, for example, a suitable heart rate, a well-modulated excretory capacity of the kidneys, or an appropriate activity of the central nervous system. Oxygen is a vital substrate for the human body, for no metabolic pathway can generate this substance for the organism. It seems to be, therefore, reasonable to assume that the different organs have developed mechanisms to guarantee a constant oxygen supply. That means, besides its role as electron receptor in the respiratory chain, oxygen is involved as a signal in different physiological reactions. This process is defined as oxygen sensing and describes why cells are able to respond to PO2 changes by altering the corresponding metabolic and membrane properties in order to regulate cell-specific activities and to maintain a regular function. To elucidate the mechanisms of the O2 sensing process this article first describes this phenomenon in different biological systems to continue with a description of its basic properties. The article will be summarized by a model, which may help to stimulate further discussion about O2 sensing.
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© 1988 Springer-Verlag Berlin Heidelberg
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Acker, H. (1988). Possible Mechanisms of O2 Sensing in Different Cell Types. In: Acker, H. (eds) Oxygen Sensing in Tissues. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83444-8_5
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DOI: https://doi.org/10.1007/978-3-642-83444-8_5
Publisher Name: Springer, Berlin, Heidelberg
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