PO2-Induced Changes of Membrane Potential and Tension in Vascular Smooth Musculature

  • G. Siegel
  • J. Grote


That a decrease in oxygen tension leads to vasodilatation has been known from the literature for a long time. Mechanical measurements demonstrate that hypoxia effects relaxation of vascular strips [8, 9,10, 33], vasodilatation in perfused vessels [5, 6, 7,11], or an increase in blood flow [3, 4,13,17,19, 32]. Electrophysiological investigations during oxygen deficiency, especially intracellular measurements of the membrane potential of vascular smooth muscle cells, do not exist. It has been reported merely that a PO2 decrease in the rat portal vein restricts spontaneous spike discharges and finally causes their complete cessation [16]. Johansson and Somlyo [18] supposed that vasodilatation with hypoxia possibly has an electrophysiological correlate.


Membrane Potential Vascular Smooth Muscle Vascular Smooth Muscle Cell Oxygen Tension Electromechanical Coupling 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • G. Siegel
    • 1
  • J. Grote
    • 2
  1. 1.Institute of Physiology, Biophysical Research GroupFree University of BerlinBerlin 33Germany
  2. 2.Institute of PhysiologyUniversity of BonnBonn 1Germany

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